Vertebrogenic Pain: A Paradigm Shift in Diagnosis and Treatment of Axial Low Back Pain

The Effectiveness of Intraosseous Basivertebral Nerve Radiofrequency Ablation for the Treatment of Vertebrogenic Low Back Pain: An Updated Systematic Review with Single-Arm Meta-analysis

(2022) Aaron Conger et al.   PAIN MEDICINE

Serum biomarkers for Modic changes in patients with chronic low back pain

(2021) Jaro Karppinen et al.   EUROPEAN SPINE JOURNAL

Measurement of vertebral endplate bone marrow lesion (Modic change) composition with water–fat MRI and relationship to patient-reported outcome measures

(2021) Aaron J. Fields et al.   EUROPEAN SPINE JOURNAL

Lumbar Bracing for Chronic Low Back Pain

(2021) Thiru M. Annaswamy et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Motion Characteristics of the ‘Functional Spinal Unit’ During Lumbar Disc Injection (Discography) including Comparison between Normal and Degenerative Levels

(2021) Walter S Bartynski et al.   PAIN MEDICINE

Lumbar Facet Fluid–Does It Correlate with Dynamic Instability in Degenerative Spondylolisthesis? A Systematic Review and Meta-Analysis

(2021) Ankita Aggarwal et al.   World Neurosurgery

The association between vertebral endplate structural defects and back pain: a systematic review and meta-analysis

(2021) Aliyu Lawan et al.   EUROPEAN SPINE JOURNAL

Intraosseous Basivertebral Nerve Radiofrequency Ablation for the Treatment of Vertebral Body Endplate Low Back Pain: Current Evidence and Future Directions

(2021) Adam Michalik et al.   PAIN MEDICINE

Prospective, randomized, multicenter study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 12-month results

(2021) Matthew Smuck et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Vertebral Endplate Changes Correlate with Presence of Cartilaginous Endplate in the Herniated Disc Tissue: Factor Predicting Failure of Conservative Treatment

(2021) Rabia Latif et al.   Asian Spine Journal

Radiofrequency ablation of the basivertebral nerve in the treatment of chronic low back pain: analysis of a small clinical series

(2021) Ia. V. Fishchenko et al.   Hirurgia Pozvonochnika

Integrative analysis of metabolomic, genomic, and imaging-based phenotypes identify very-low-density lipoprotein as a potential risk factor for lumbar Modic changes

(2021) Yiming Li et al.   EUROPEAN SPINE JOURNAL

Obesity could be associated with poor paraspinal muscle quality at upper lumbar levels and degenerated spine at lower lumbar levels: Is this a domino effect?

(2021) Emel Ece Özcan-Ekşi et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Consensus practice guidelines on interventions for cervical spine (facet) joint pain from a multispecialty international working group

(2021) Robert W Hurley et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Objective features of sedentary time and light activity differentiate people with low back pain from healthy controls, A pilot study

(2021) Christy Tomkins-Lane et al.   Spine Journal

Is antibiotic treatment effective in the management of chronic low back pain with disc herniation? Study protocol for a randomised controlled trial

(2021) Donna M. Urquhart et al.   Trials

Detailed Subphenotyping of Lumbar Modic Changes and Their Association with Low Back Pain in a Large Population-Based Study: The Wakayama Spine Study

(2021) Masatoshi Teraguchi et al.   Pain and Therapy

Endplate defects, not the severity of spinal stenosis, contribute to low back pain in patients with lumbar spinal stenosis

(2021) Masakazu Minetama et al.   Spine Journal

Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature

(2020) Hyeun Sung Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vertebral intraosseous plasma rich in growth factor (PRGF-Endoret) infiltrations as a novel strategy for the treatment of degenerative lesions of endplate in lumbar pathology: description of technique and case presentation

(2020) Fernando Kirchner et al.   Journal of Orthopaedic Surgery and Research

Long-term outcomes following intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 5-year treatment arm results from a prospective randomized double-blind sham-controlled multi-center study

(2020) Jeffrey S. Fischgrund et al.   EUROPEAN SPINE JOURNAL

Gait features for discriminating between mobility-limiting musculoskeletal disorders: lumbar spinal stenosis and knee osteoarthritis

(2020) Charles Odonkor et al.   GAIT & POSTURE

Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes)

(2020) Stefan Dudli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group

(2020) Steven P Cohen et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - secondary analyses of a randomised, placebo-controlled trial (the AIM study)

(2020) Lars Christian Haugli Bråten et al.   BMC MUSCULOSKELETAL DISORDERS

Proposal for a New Scoring System for Spinal Degeneration: Mo-Fi-Disc

(2020) Murat Şakir Ekşi et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Intra-osseous basivertebral nerve radiofrequency ablation (BVA) for the treatment of vertebrogenic chronic low back pain

(2020) Aldo Eros De Vivo et al.   NEURORADIOLOGY

Oedema on STIR modified the effect of amoxicillin as treatment for chronic low back pain with Modic changes—subgroup analysis of a randomized trial

(2020) Per Martin Kristoffersen et al.   EUROPEAN RADIOLOGY

Lumbar intervertebral disc degeneration, end-plates and paraspinal muscle changes in children and adolescents with low-back pain

(2020) Murat Ş. Ekşi et al.   JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B

Magnetic resonance spectroscopy (MRS) can identify painful lumbar discs and may facilitate improved clinical outcomes of lumbar surgeries for discogenic pain

(2019) Matthew G. Gornet et al.   EUROPEAN SPINE JOURNAL

A prospective, open-label, single-arm, multi-center study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain

(2019) Eeric Truumees et al.   EUROPEAN SPINE JOURNAL

Association Between Opioid Use and Patient-Reported Outcomes in a Randomized Trial Evaluating Basivertebral Nerve Ablation for the Relief of Chronic Low Back Pain

(2019) John D Markman et al.   NEUROSURGERY

A prospective, randomized, multicenter study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain

(2019) Jad G. Khalil et al.   Spine Journal

Relationship between Endplate Defects, Modic Change, Disc Degeneration, and Facet Joint Degeneration in Patients with Low Back Pain

(2019) Bin Lv et al.   Biomed Research International

Bacteria: back pain, leg pain and Modic sign—a surgical multicentre comparative study

(2019) Peter Fritzell et al.   EUROPEAN SPINE JOURNAL

The Effectiveness of Radiofrequency Ablation of Medial Branch Nerves for Chronic Lumbar Facet Joint Syndrome in Patients Selected by Guideline-Concordant Dual Comparative Medial Branch Blocks

(2019) Aaron Conger et al.   PAIN MEDICINE

Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial

(2019) Lars Christian Haugli Bråten et al.   BMJ-British Medical Journal

Prevalence of Facet Effusion and Its Relationship with Lumbar Spondylolisthesis and Low Back Pain: The Wakayama Spine Study

(2019) Kazunori Shinto et al.   Journal of Pain Research

Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham-controlled multi-center study

(2018) Jeffrey S. Fischgrund et al.   EUROPEAN SPINE JOURNAL

Nerves and blood vessels in degenerated intervertebral discs are confined to physically disrupted tissue

(2018) Polly Lama et al.   JOURNAL OF ANATOMY

Endplate Defect is Heritable, Associated With Low Back Pain and Triggers Intervertebral Disc Degeneration

(2018) Sabrina Munir et al.   SPINE

Digital biomarkers of spine and musculoskeletal disease from accelerometers: Defining phenotypes of free-living physical activity in knee osteoarthritis and lumbar spinal stenosis

(2018) Christy Tomkins-Lane et al.   Spine Journal

Severe Lumbar Intervertebral Disc Degeneration Is Associated with Modic Changes and Fatty Infiltration in the Paraspinal Muscles at all Lumbar Levels, Except for L1-L2: A Cross-Sectional Analysis of 50 Symptomatic Women and 50 Age-Matched Symptomatic Men

(2018) Emel Ece Özcan-Ekşi et al.   World Neurosurgery

Short-term pain evolution in chronic low back pain with Modic type 1 changes treated by a lumbar rigid brace: A retrospective study

(2018) Laura Boutevillain et al.   Annals of Physical and Rehabilitation Medicine

ISSLS PRIZE IN BASIC SCIENCE 2017: Intervertebral disc/bone marrow cross-talk with Modic changes

(2017) Stefan Dudli et al.   EUROPEAN SPINE JOURNAL

Diagnostic Value, Prognostic Value, and Safety of Provocation Discography

(2017) Zachary L McCormick et al.   PAIN MEDICINE

Ablation of the basivertebral nerve for treatment of back pain: a clinical study

(2017) Stephan Becker et al.   Spine Journal

Hybrid Bone Single Photon Emission Computed Tomography Imaging in Evaluation of Chronic Low Back Pain: Correlation with Modic Changes and Degenerative Disc Disease

(2017) Vittorio M. Russo et al.   World Neurosurgery

Pathobiology of Modic changes

(2016) Stefan Dudli et al.   EUROPEAN SPINE JOURNAL

Evaluation of the disco-vertebral junction using ultrashort time-to-echo magnetic resonance imaging: inter-reader agreement and association with vertebral endplate lesions

(2016) Karen C. Chen et al.   SKELETAL RADIOLOGY

MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis

(2015) W. Brinjikji et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Neural innervation patterns in the sacral vertebral body

(2015) Sean Degmetich et al.   EUROPEAN SPINE JOURNAL

Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability

(2015) Devina Purmessur et al.   Spine Journal

Treatment of painful Modic type I changes by vertebral augmentation with bioactive resorbable bone cement

(2014) Salvatore Masala et al.   NEURORADIOLOGY

Can discoblock replace discography for identifying painful degenerated discs?

(2013) Michael Putzier et al.   EUROPEAN JOURNAL OF RADIOLOGY

Inflammatory pain pattern and pain with lumbar extension associated with Modic 1 changes on MRI: a prospective case–control study of 120 patients

(2013) F. Bailly et al.   EUROPEAN SPINE JOURNAL

Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy

(2013) Hanne B. Albert et al.   EUROPEAN SPINE JOURNAL

Ultrashort time-to-echo MRI of the cartilaginous endplate: Technique and association with intervertebral disc degeneration

(2013) Travis Law et al.   Journal of Medical Imaging and Radiation Oncology

Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc

(2013) Aaron J. Fields et al.   Spine Journal

Intervertebral disc degeneration: evidence for two distinct phenotypes

(2012) Michael A. Adams et al.   JOURNAL OF ANATOMY

Multivariable Analyses of the Relationships Between Age, Gender, and Body Mass Index and the Source of Chronic Low Back Pain

(2012) Michael J. DePalma et al.   PAIN MEDICINE

Factors determining the success of radiofrequency denervation in lumbar facet joint pain: a prospective study

(2011) Konrad Streitberger et al.   EUROPEAN SPINE JOURNAL

Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra

(2011) Jeannie F. Bailey et al.   JOURNAL OF ANATOMY

What Is the Source of Chronic Low Back Pain and Does Age Play a Role?

(2011) Michael J. DePalma et al.   PAIN MEDICINE

Provocative lumbar discography versus functional anesthetic discography: a comparison of the results of two different diagnostic techniques in 52 patients with chronic low back pain

(2011) Todd F. Alamin et al.   Spine Journal

Does the Location of Low Back Pain Predict Its Source?

(2011) Michael J. DePalma et al.   PM&R

MRI Analysis of the Lumbar Spine: Can It Predict Response to Diagnostic and Therapeutic Facet Procedures?

(2010) Milan P. Stojanovic et al.   CLINICAL JOURNAL OF PAIN

The Association Between Lumbar Disc Degeneration and Low Back Pain

(2010) Evelien I. T. de Schepper et al.   SPINE

Diagnosis and surgical treatment of back pain originating from endplate

(2009) Baogan Peng et al.   EUROPEAN SPINE JOURNAL

Predictors of new vertebral endplate signal (Modic) changes in the general population

(2009) Tue Secher Jensen et al.   EUROPEAN SPINE JOURNAL

Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals

(2009) Kenneth M. C. Cheung et al.   SPINE

Lumbar zygapophysial (facet) joint radiofrequency denervation success as a function of pain relief during diagnostic medial branch blocks: a multicenter analysis

(2007) Steven P. Cohen et al.   Spine Journal