Synthesis of gem-Difluorinated 1,3-Dienes via Synergistic Cu/Pd-Catalyzed Borodifluorovinylation of Alkynes

Experimental and Computational Studies on the Iron‐Catalyzed Selective and Controllable Defluorosilylation of Unactivated Aliphatic gem‐Difluoroalkenes

(2021) Zhang Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly γ‐Selective Arylation and Carbonylative Arylation of 3‐Bromo‐3,3‐difluoropropene via Nickel Catalysis

(2021) Ran Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoselective catalytic hydrodefluorination of trifluoromethylalkenes towards mono-/gem-di-fluoroalkenes under metal-free conditions

(2021) Jingjing Zhang et al.   Nature Communications

Asymmetric Synthesis of 2,2‐Difluorotetrahydrofurans through Palladium‐Catalyzed Formal [3 + 2] Cycloaddition

(2021) Gang Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselective Synthesis of Difluorinated 1,3-Dienes via Palladium-Catalyzed C–F Bond Activation of Tetrasubstituted gem-Difluoroalkenes

(2021) Yanhui Wang et al.   ORGANIC LETTERS

Stereoselective gem-Difluorovinylation of gem-Difluorinated Cyclopropanes Enabled by Ni/Pd Cooperative Catalysis

(2021) Baojian Xiong et al.   ACS Catalysis

gem-Difluorovinylation of alkynyl bromoarenes via dual nickel-/palladium-catalyzed cross-electrophile coupling

(2021) Haotian Sun et al.   Organic Chemistry Frontiers

Four‐Component Borocarbonylation of Vinylarenes Enabled by Cooperative Cu/Pd Catalysis: Access to β‐Boryl Ketones & β‐Boryl Vinyl Esters

(2020) Xiao-Feng Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Synthesis of TY‐Phos and Application in Palladium‐Catalyzed Enantioselective Fluoroarylation of gem ‐Difluoroalkenes

(2020) Tao‐Yan Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cp*Rh(III)-Catalyzed C–H Bond Difluorovinylation of Indoles with α,α-Difluorovinyl Tosylate

(2019) Lisheng Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Transition Metal-Mediated and -Catalyzed C-F Bond Activation via Fluorine Elimination

(2018) Takeshi Fujita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselective Synthesis of Borylated 1,3-Dienes by Synergistic Cu/Pd Catalysis

(2018) Nuria Vázquez-Galiñanes et al.   ChemCatChem

Copper-boryl mediated organic synthesis

(2018) David Hemming et al.   CHEMICAL SOCIETY REVIEWS

Copper-Catalyzed Asymmetric Defluoroborylation of 1-(Trifluoromethyl)Alkenes

(2018) Pan Gao et al.   Chem

Photoredox/Nickel-Catalyzed Single-Electron Tsuji-Trost Reaction: Development and Mechanistic Insights

(2018) Jennifer K. Matsui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluoro-Hydroxylation of gem -Difluoroalkenes: Synthesis of 18 O-labeled α-CF3 Alcohols

(2018) Jingyu Hu et al.   CHINESE JOURNAL OF CHEMISTRY

Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors

(2018) Agustin Casimiro-Garcia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes

(2017) Hironobu Sakaguchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Defluorinative Reductive Cross-Coupling of gem-Difluoroalkenes with Unactivated Secondary and Tertiary Alkyl Halides

(2017) Xi Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Experimental and Theoretical Studies on Rhodium-Catalyzed Coupling of Benzamides with 2,2-Difluorovinyl Tosylate: Diverse Synthesis of Fluorinated Heterocycles

(2017) Jia-Qiang Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

(2017) Xuxue Zhang et al.   TETRAHEDRON LETTERS

Synergistic Copper/Palladium Catalysis for the Regio- and Stereoselective Synthesis of Borylated Skipped Dienes

(2017) Jaime Mateos et al.   ACS Catalysis

Palladium-Catalyzed Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids: Stereoselective Synthesis of Monofluorostilbenes

(2016) Richard T. Thornbury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Transformations Using Cu-H, Cu-B, and Cu-Si as Active Catalyst Species

(2016) Yasushi Tsuji et al.   CHEMICAL RECORD

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

F– Nucleophilic-Addition-Induced Allylic Alkylation

(2016) Panpan Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Enabled, Copper-Catalyzed Regio- and Stereoselective Synthesis of Trialkylsubstituted Alkenylboronates from Unactivated Internal Alkynes

(2016) Taisuke Itoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Difluorinated Enynes through Sonogashira-Type Coupling

(2016) Takumi Fujino et al.   ORGANIC LETTERS

Ligand-Controlled Regiodivergent Copper-Catalyzed Alkylboration of Alkenes

(2015) Wei Su et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reaction of Diazo Compounds with Difluorocarbene: An Efficient Approach towards 1,1-Difluoroolefins

(2015) Zhikun Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Versatile Relay and Cooperative Palladium(0)N-Heterocyclic Carbene/Copper(I)N-Heterocyclic Carbene Catalysis for the Synthesis of Tri- and Tetrasubstituted Alkenes

(2015) Mathieu Lesieur et al.   ChemCatChem

A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes

(2015) Tao Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium-catalysed C(sp2)–C(sp2) bond formation via C–H/C–F activation

(2015) Panpan Tian et al.   Nature Communications

Copper-Catalyzed Cross-Coupling of Boronic Esters with Aryl Iodides and Application to the Carboboration of Alkynes and Allenes

(2014) Yiqing Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Arylboration of Alkenes by Cooperative Palladium/Copper Catalysis

(2014) Kazuhiko Semba et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

(2013) Jian Zheng et al.   CHEMICAL COMMUNICATIONS

Copper-Catalyzed gem-Difluoroolefination of Diazo Compounds with TMSCF3 via C–F Bond Cleavage

(2013) Mingyou Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper(I)-Catalyzed Formal Carboboration of Alkynes: Synthesis of Tri- and Tetrasubstituted Vinylboronates

(2012) Ricardo Alfaro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Boracarboxylation of Alkynes with Diborane and Carbon Dioxide by an N-Heterocyclic Carbene Copper Catalyst

(2012) Liang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Nickel-Catalyzed Cyclization of Difluoro-Substituted 1,6-Enynes with Organozinc Reagents through the Stereoselective Activation of CF Bonds: Synthesis of Bicyclo[3.2.0]heptene Derivatives

(2010) Manabu Takachi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Difluoromethyl 2-Pyridyl Sulfone: A Newgem-Difluoroolefination Reagent for Aldehydes and Ketones

(2010) Yanchuan Zhao et al.   ORGANIC LETTERS

1-tert-Butyl-1H-tetrazol-5-yl fluoromethyl sulfone (TBTSO2CH2F): a versatile fluoromethylidene synthon and its use in the synthesis of monofluorinated alkenes via Julia–Kocienski olefination

(2010) Lingui Zhu et al.   TETRAHEDRON

Direct Vinylation and Difluorovinylation of Arylboronic Acids Using Vinyl- and 2,2-Difluorovinyl Tosylates via the Suzuki−Miyaura Cross Coupling

(2008) Thomas M. Gøgsig et al.   JOURNAL OF ORGANIC CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS