Distinguishing post‐translational modifications in dominantly inherited frontotemporal dementias: FTLD‐TDP Type A ( GRN ) vs Type B ( C9orf72 )

Detecting Differences in Prion Protein Conformation by Quantifying Methionine Oxidation

(2022) Christopher J. Silva et al.   ACS Omega

Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?

(2021) Erin L. Sternburg et al.   TRENDS IN BIOCHEMICAL SCIENCES

Post-Translational Modifications Modulate Proteinopathies of TDP-43, FUS and hnRNP-A/B in Amyotrophic Lateral Sclerosis

(2021) Stefania Farina et al.   Frontiers in Molecular Biosciences

Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis

(2021) Nilo Riva et al.   BRAIN

FTLD‐TDP assemblies seed neoaggregates with subtype‐specific features via a prion‐like cascade

(2021) Pierre De Rossi et al.   EMBO REPORTS

Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer’s Disease

(2021) Evan E. Hubbard et al.   JOURNAL OF PROTEOME RESEARCH

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

MS-based strategies for identification of protein SUMOylation modification

(2019) Zenghua Sheng et al.   ELECTROPHORESIS

Structural Insights Into TDP-43 and Effects of Post-translational Modifications

(2019) Liberty François-Moutal et al.   Frontiers in Molecular Neuroscience

TDP-43 post-translational modifications in health and disease

(2018) Emanuele Buratti   EXPERT OPINION ON THERAPEUTIC TARGETS

How many human proteoforms are there?

(2018) Ruedi Aebersold et al.   Nature Chemical Biology

Global Post-Translational Modification Discovery

(2017) Qiyao Li et al.   JOURNAL OF PROTEOME RESEARCH

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

(2016) Waltraud Mair et al.   ANALYTICAL CHEMISTRY

Proteogenomics connects somatic mutations to signalling in breast cancer

(2016) Philipp Mertins et al.   NATURE

Structural insights into the multi-determinant aggregation of TDP-43 in motor neuron-like cells

(2016) F. Bozzo et al.   NEUROBIOLOGY OF DISEASE

Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains

(2016) Fuyuki Kametani et al.   Scientific Reports

An acetylation switch controls TDP-43 function and aggregation propensity

(2015) Todd J. Cohen et al.   Nature Communications

The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43

(2014) Nicole F. Liachko et al.   PLoS Genetics

CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration

(2013) Nicole F. Liachko et al.   ANNALS OF NEUROLOGY

Large-scale identification of ubiquitination sites by mass spectrometry

(2013) Namrata D Udeshi et al.   Nature Protocols

Molecular analysis and biochemical classification of TDP-43 proteinopathy

(2012) Hiroshi Tsuji et al.   BRAIN

Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

(2012) Houjiang Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

(2011) Hiroshi Tsuji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hyperphosphorylation as a Defense Mechanism to Reduce TDP-43 Aggregation

(2011) Huei-Ying Li et al.   PLoS One

Identification of casein kinase-1 phosphorylation sites on TDP-43

(2009) Fuyuki Kametani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43

(2009) Takashi Nonaka et al.   HUMAN MOLECULAR GENETICS

Expression of TDP-43 C-terminal Fragmentsin VitroRecapitulates Pathological Features of TDP-43 Proteinopathies

(2009) Lionel M. Igaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2008) Masato Hasegawa et al.   ANNALS OF NEUROLOGY

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS

(2008) Yuki Inukai et al.   FEBS LETTERS