Fast versus slow disease progression in amyotrophic lateral sclerosis–clinical and genetic factors at the edges of the survival spectrum

Clinico-genetic findings in 509 frontotemporal dementia patients

(2021) Matias Wagner et al.   MOLECULAR PSYCHIATRY

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

(2021) Wouter van Rheenen et al.   NATURE GENETICS

A natural history comparison of SOD1-mutant patients with amyotrophic lateral sclerosis between Chinese and German populations

(2021) Lu Tang et al.   Translational Neurodegeneration

Effect of high-caloric nutrition on serum neurofilament light chain levels in amyotrophic lateral sclerosis

(2020) Johannes Dorst et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

(2020) Timothy Miller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis

(2020) Sabrina Paganoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early weight loss in amyotrophic lateral sclerosis: outcome relevance and clinical correlates in a population-based cohort

(2019) Cristina Moglia et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Prognostic factors in ALS: a comparison between Germany and China

(2019) Johannes Dorst et al.   JOURNAL OF NEUROLOGY

Mitochondrial DNA mutation analysis from exome sequencing – a more holistic approach in diagnostics of suspected mitochondrial disease

(2019) Matias Wagner et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Prospective natural history study of C9orf72 ALS clinical characteristics and biomarkers

(2019) Alexander J. Cammack et al.   NEUROLOGY

Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia

(2019) Matias Wagner et al.   Nature Communications

Phenotypes and malignancy risk of different FUS mutations in genetic amyotrophic lateral sclerosis

(2019) Marcel Naumann et al.   Annals of Clinical and Translational Neurology

Effect of High‐Caloric Nutrition on Survival in Amyotrophic Lateral Sclerosis

(2019) Albert C. Ludolph et al.   ANNALS OF NEUROLOGY

Phenotypic differences of amyotrophic lateral sclerosis (ALS) in China and Germany

(2018) Angela Rosenbohm et al.   JOURNAL OF NEUROLOGY

Comprehensive analysis of the mutation spectrum in 301 German ALS families

(2018) Kathrin Müller et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial

(2018) Albert C Ludolph et al.   LANCET NEUROLOGY

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

(2018) Aude Nicolas et al.   NEURON

Life course body mass index and risk and prognosis of amyotrophic lateral sclerosis: results from the ALS registry Swabia

(2017) Raphael Simon Peter et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Epidemiology of amyotrophic lateral sclerosis in Southern Germany

(2017) Angela Rosenbohm et al.   JOURNAL OF NEUROLOGY

Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis

(2017) Martin Gorges et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis

(2017) Zhang-Yu Zou et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis

(2017) Beben Benyamin et al.   Nature Communications

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis

(2016) Pauline Vercruysse et al.   BRAIN

Defining SOD1 ALS natural history to guide therapeutic clinical trial design

(2016) Taha Bali et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism

(2016) Rebekah M Ahmed et al.   LANCET NEUROLOGY

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

(2016) Kevin P Kenna et al.   NATURE GENETICS

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

(2016) Wouter van Rheenen et al.   NATURE GENETICS

Population-Based Evidence that Survival in Amyotrophic Lateral Sclerosis Is Related to Weight Loss at Diagnosis

(2016) Benoît Marin et al.   Neurodegenerative Diseases

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis

(2014) Matthew D Cykowski et al.   Acta Neuropathologica Communications

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Evidence for an oligogenic basis of amyotrophic lateral sclerosis

(2012) Marka van Blitterswijk et al.   HUMAN MOLECULAR GENETICS

Prognostic factors in ALS: A critical review

(2009) Adriano Chiò et al.   Amyotrophic Lateral Sclerosis

Hypermetabolism in ALS patients: an early and persistent phenomenon

(2009) C. Bouteloup et al.   JOURNAL OF NEUROLOGY