Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design

Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria

(2016) Christopher W. Seymour et al.   CRITICAL CARE MEDICINE

A Framework for the Development and Interpretation of Different Sepsis Definitions and Clinical Criteria

(2016) Derek C. Angus et al.   CRITICAL CARE MEDICINE

New Strategies for Effective Therapeutics in Critically Ill Patients

(2016) Michael A. Matthay et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

(2016) Giacomo Bellani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Developing a Clinically Feasible Personalized Medicine Approach to Pediatric Septic Shock

(2015) Hector R. Wong et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care

(2015) Theodore J. Iwashyna et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Randomized, Placebo-Controlled Trial of Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis

(2015) David R. Janz et al.   CRITICAL CARE MEDICINE

Seven Questions for Personalized Medicine

(2015) Michael J. Joyner et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Corticosteroids for Severe Community-Acquired Pneumonia

(2015) Richard G. Wunderink   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Corticosteroids on Treatment Failure Among Hospitalized Patients With Severe Community-Acquired Pneumonia and High Inflammatory Response

(2015) Antoni Torres et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis: a roadmap for future research

(2015) Jonathan Cohen et al.   LANCET INFECTIOUS DISEASES

Trial of Early, Goal-Directed Resuscitation for Septic Shock

(2015) Paul R. Mouncey et al.   NEW ENGLAND JOURNAL OF MEDICINE

BRAF-mutant melanoma: treatment approaches, resistance mechanisms, and diagnostic strategies

(2015) Francesco Spagnolo et al.   OncoTargets and Therapy

Association between Source of Infection and Hospital Mortality in Patients Who Have Septic Shock

(2014) Aleksandra Leligdowicz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Next Generation of Sepsis Clinical Trial Designs

(2014) Steven M. Opal et al.   CRITICAL CARE MEDICINE

Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts

(2014) Vincent Liu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of High-Dose Vitamin D3on Hospital Length of Stay in Critically Ill Patients With Vitamin D Deficiency

(2014) Karin Amrein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012

(2014) Kirsi-Maija Kaukonen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Trial of the Route of Early Nutritional Support in Critically Ill Adults

(2014) Sheila E. Harvey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials

(2014) Carolyn S Calfee et al.   Lancet Respiratory Medicine

Comparison of the Berlin Definition for Acute Respiratory Distress Syndrome with Autopsy

(2013) Arnaud W. Thille et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Two Decades of Mortality Trends Among Patients With Severe Sepsis

(2013) Elizabeth K. Stevenson et al.   CRITICAL CARE MEDICINE

Multiplex PCR System for Rapid Detection of Pathogens in Patients with Presumed Sepsis – A Systemic Review and Meta-Analysis

(2013) Shy-Shin Chang et al.   PLoS One

Cost and Health Care Utilization in ARDS—Different from Other Critical Illness?

(2013) Thomas Bice et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Systemic inflammatory response syndrome (SIRS)

(2013) Robert A Balk   Virulence

The Comparison of Spontaneous Breathing and Muscle Paralysis in Two Different Severities of Experimental Lung Injury*

(2012) Takeshi Yoshida et al.   CRITICAL CARE MEDICINE

Acute Respiratory Distress Syndrome

(2012)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association Between Use of Lung-Protective Ventilation With Lower Tidal Volumes and Clinical Outcomes Among Patients Without Acute Respiratory Distress Syndrome

(2012) Ary Serpa Neto et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis

(2012) M Man et al.   PHARMACOGENOMICS JOURNAL

Problems of stopping trials early

(2012) G. H. Guyatt et al.   BMJ-British Medical Journal

Systemic Steroids in Severe Sepsis and Septic Shock

(2011) Gourang P. Patel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epidemiology of ARDS and ALI

(2011) Ross Blank et al.   CRITICAL CARE CLINICS

Recombinant Surfactant Protein C–based Surfactant for Patients with Severe Direct Lung Injury

(2010) Roger G. Spragg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Higher vs Lower Positive End-Expiratory Pressure in Patients With Acute Lung Injury and Acute Respiratory Distress Syndrome

(2010) Matthias Briel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome

(2010) Laurent Papazian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of pediatric septic shock subclasses based on genome-wide expression profiling

(2009) Hector R Wong et al.   BMC Medicine

Bayesian statistics in oncology

(2009) Michel Adamina et al.   CANCER

Gene expression profiling: Classification of mice with left ventricle systolic dysfunction using microarray analysis*

(2009) Jim Wong et al.   CRITICAL CARE MEDICINE

Pharmacological treatments for acute respiratory distress syndrome

(2009) Angela J Frank et al.   Current Opinion in Critical Care

Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial

(2009) William D Schweickert et al.   LANCET

Clinical phenotype of cystic fibrosis patients with the G551D mutation

(2009) D.M. Comer et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial

(2008) Timothy D Girard et al.   LANCET

Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock

(2008) James A. Russell et al.   NEW ENGLAND JOURNAL OF MEDICINE