Teixobactin kills bacteria by a two-pronged attack on the cell envelope

The Science of Antibiotic Discovery

(2020) Kim Lewis   CELL

Visualization of Single Molecules Building a Viral Capsid Protein Lattice through Stochastic Pathways

(2020) Alejandro Valbuena et al.   ACS Nano

Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization

(2020) Sourav Maity et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mode of action of teixobactins in cellular membranes

(2020) Rhythm Shukla et al.   Nature Communications

De novo resistance to arg10-teixobactin occurs slowly and is costly

(2020) Daniel G. Lloyd et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model

(2020) William S. Lawrence et al.   Pathogens

Shifts in the selectivity filter dynamics cause modal gating in K+ channels

(2019) Shehrazade Jekhmane et al.   Nature Communications

Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics

(2019) Yu Zong et al.   Nature Communications

Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin

(2019) Hyunjun Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo

(2018) Anish Parmar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural studies suggest aggregation as one of the modes of action for teixobactin

(2018) Carl Öster et al.   Chemical Science

High-resolution NMR studies of antibiotics in cellular membranes

(2018) João Medeiros-Silva et al.   Nature Communications

X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly

(2018) Hyunjun Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

(2018) Alessandro Cassini et al.   LANCET INFECTIOUS DISEASES

Investigation of the N-Terminus Amino Function of Arg10-Teixobactin

(2017) Shimaa A. H. Abdel Monaim et al.   MOLECULES

Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding

(2017) Anish Parmar et al.   Chemical Science

Elucidation of the Teixobactin Pharmacophore

(2016) Hyunjun Yang et al.   ACS Chemical Biology

1 H-Detected Solid-State NMR Studies of Water-Inaccessible Proteins In Vitro and In Situ

(2016) João Medeiros-Silva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis

(2016) Darcy J Atkinson et al.   Beilstein Journal of Organic Chemistry

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Total Synthesis of Teixobactin

(2016) Andrew M. Giltrap et al.   ORGANIC LETTERS

Total synthesis of teixobactin

(2016) Kang Jin et al.   Nature Communications

Structural variations of the cell wall precursor lipid II in Gram-positive bacteria — Impact on binding and efficacy of antimicrobial peptides

(2015) Daniela Münch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Synthesis and Biological Evaluation of a Teixobactin Analogue

(2015) Yahya E. Jad et al.   ORGANIC LETTERS

Structural dynamics of the cell wall precursor lipid II in the presence and absence of the lantibiotic nisin

(2014) Dennis C. Koch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural and Functional Characterization of MppR, an Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus: Functional Diversity in the Acetoacetate Decarboxylase-like Superfamily

(2013) A. Maxwell Burroughs et al.   BIOCHEMISTRY

Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks

(2013) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Computational analysis of local membrane properties

(2013) Vytautas Gapsys et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

NMR Determination of Protein Partitioning into Membrane Domains with Different Curvatures and Application to the Influenza M2 Peptide

(2012) Tuo Wang et al.   BIOPHYSICAL JOURNAL

Icy: an open bioimage informatics platform for extended reproducible research

(2012) Fabrice de Chaumont et al.   NATURE METHODS

Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism

(2012) C.-Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Definition and testing of the GROMOS force-field versions 54A7 and 54B7

(2011) Nathan Schmid et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

An Automated Force Field Topology Builder (ATB) and Repository: Version 1.0

(2011) Alpeshkumar K. Malde et al.   Journal of Chemical Theory and Computation

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Broadband magnetization transfer using moderate radio-frequency fields for NMR with very high static fields and spinning speeds

(2010) Markus Weingarth et al.   CHEMICAL PHYSICS LETTERS

Video imaging of walking myosin V by high-speed atomic force microscopy

(2010) Noriyuki Kodera et al.   NATURE

Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II

(2010) T. Schneider et al.   SCIENCE

On the Validation of Molecular Dynamics Simulations of Saturated andcis-Monounsaturated Phosphatidylcholine Lipid Bilayers: A Comparison with Experiment

(2009) David Poger et al.   Journal of Chemical Theory and Computation

Low-power decoupling at high spinning frequencies in high static fields

(2009) Markus Weingarth et al.   JOURNAL OF MAGNETIC RESONANCE

Improved magnetization transfer in solid-state NMR with fast magic angle spinning

(2008) Markus Weingarth et al.   CHEMICAL PHYSICS LETTERS

2D 1H–31P solid-state NMR studies of the dependence of inter-bilayer water dynamics on lipid headgroup structure and membrane peptides

(2008) Tim Doherty et al.   JOURNAL OF MAGNETIC RESONANCE