Article
Nutrition & Dietetics
Malgorzata Kluch, Patrycja Bednarkiewicz, Magdalena Orzechowska, Piotr Grzelak, Ilona Kurnatowska
Summary: This study evaluated the intake of vitamin K1 and K2 in the diet of patients in the late period after kidney transplantation. The results showed that the intake of vitamin K1 was adequate, while the intake of vitamin K2 seemed insufficient.
Article
Oncology
Joanna Smajdor, Katarzyna Jedlinska, Radoslaw Porada, Anna Gorska-Ratusznik, Aleksandra Policht, Malgorzata Srottek, Grazyna Wiecek, Boguslaw Bas, Magdalena Strus
Summary: Colorectal cancer is connected to the intestinal microbiota, and vitamin K-2 may play a significant role in its prevention. This study focused on endogenous K-2 synthesized by active members of the human gut microbiome and tested its effects on Caco-2 cells, showing no harmful effects and highlighting the anti-inflammatory properties of long-chain homologs.
CANCER CELL INTERNATIONAL
(2023)
Editorial Material
Pharmacology & Pharmacy
Mette Marie Rosenkilde, Jesper Mosolff Mathiesen
Summary: G-protein-coupled receptors (GPCRs) are important drug targets with diverse ligands and coupling partners. Laboute et al.'s recent work identified GPR158 as a metabotropic glycine receptor (mGlyR), revealing a novel neuromodulatory system with implications for cognition and affective states.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Satavisha Bhattacharya, Ahmadreza Nezamzadeh, Jianfeng Zhu, Jens Muller
Summary: Silicon-bridged [1]ferrocenophanes have been extensively studied, but there were no reports on silicon-bridged [1]ruthenocenophanes. We successfully synthesized sila[1]ruthenocenophanes and studied their molecular structures and heat release behavior. By analyzing the kinetics of the salt-metathesis approach, we explain why it took so long to prepare the first sila[1]ruthenocenophanes.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Multidisciplinary Sciences
Anthony Hegg, Jinning Hou, Wei Ku
Summary: Research suggests the possibility of a Bose metal phase, which theory currently relies on impurity-based disorder; a proposed universal homogeneous theory for the Bose metal involves geometric frustration confining quantum coherence, resulting in a gapless insulator characterized by dissipative flow that vanishes in the low-energy limit.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Hanna Cheropkina, Gianluca Catucci, Arianna Marucco, Ivana Fenoglio, Gianfranco Gilardi, Sheila J. Sadeghi
Summary: Out of the five isoforms of human flavin-containing monooxygenase, FMO1 and FMO3 are the most relevant to Phase I drug metabolism. FMO1 was found to form a highly stable C4ahydroperoxyflavin intermediate upon reduction by NADPH and in the presence of O-2, which is more stable compared to FMO3. Additionally, uncoupling reactions of FMO1 show minimal uncoupling in the presence of substrate.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Alessandra Serrao, Manuela Merli, Benedetta Lucani, Francesca Aprile, Luciano Fiori, Stefania Gioia, Massimo Breccia, Olivero Riggio, Antonio Chistolini
Summary: This study investigated the efficacy and safety of long-term DOACs therapy compared to VKA for secondary prophylaxis in high-risk SVT patients. Results showed that DOACs could be an effective and safe alternative to VKA, with similar rates of thrombotic events but fewer minor bleedings in DOAC-treated patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Nutrition & Dietetics
Simon Fiesack, Anne Smits, Maissa Rayyan, Karel Allegaert, Philippe Alliet, Wim Arts, An Bael, Luc Cornette, Ann De Guchtenaere, Nele De Mulder, Isabel George, Elisabeth Henrion, Kirsten Keiren, Nathalie Kreins, Marc Raes, Pierre Philippet, Bart Van Overmeire, Myriam Van Winckel, Vinciane Vlieghe, Yvan Vandenplas
Summary: Neonatal vitamin K prophylaxis is crucial for preventing VKDB, with recommended IM injection of 1 or 2 mg vitamin K at birth, alternative oral administration for parental refusal, and specific considerations for preterm infants <32 weeks.
Article
Chemistry, Multidisciplinary
Xinyi Han, Jinpeng Xin, Yangrong Yao, Zhihui Liang, Yongfu Qiu, Muqing Chen, Shangfeng Yang
Summary: Endohedral metallofullerenes (EMFs) are a type of metal/carbon hybrid molecule with unique physicochemical properties, and they have potential applications in various fields. Although numerous EMFs have been synthesized and confirmed, some members of the EMF family have not been observed using conventional separation methods due to the difficulty in separating them from carbon soot. In this study, we successfully captured a dysprosium-based EMF and confirmed its structure using crystallography. The addition of a benzyl radical allowed for the stabilization of the EMF in organic solvents, enriching the family of endohedral fullerenes.
Editorial Material
Biochemistry & Molecular Biology
Georgina K. C. Dowsett, Giles S. H. Yeo
Summary: GLP-1 receptor agonists are highly effective in the treatment of obesity, but their mechanisms of action and whether they can be the long-sought-after solution to obesity are still being studied and discussed.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jin-Xin Zhao, Yu-Xuan Chang, Chi He, Benjamin J. Burke, Michael R. Collins, Matthew Del Bel, Jeff Elleraas, Gary M. Gallego, T. Patrick Montgomery, James J. Mousseau, Sajiv K. Nair, Matthew A. Perry, Jillian E. Spangler, Julien C. Vantourout, Phil S. Baran
Summary: This paper describes a new method for synthesizing 1,2difunctionalized bicyclo[1.1.1]pentanes that potentially mimic ortho/meta-substituted arenes, and successfully synthesizes useful building blocks. Additionally, it can prepare various substituted benzene analogs and simple molecular matched pairs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nutrition & Dietetics
Hiromitsu Ohmori, Akihiko Kato, Yuka Shirai, Reiji Fukano, Akiko Nagae, Masami Yamasaki, Junko Komenaka, Eiji Imamura, Masao Kumode, Takafumi Miyachi
Summary: Nutritional support is crucial for patients with severe motor and intellectual disabilities (SMID) who require long-term tube feeding. This study found that approximately half of the patients had subclinical vitamin K deficiency, which could potentially be improved with vitamin K2 supplementation.
Review
Hematology
Shixuan Liu, Guomin Shen, Weikai Li
Summary: Vitamin K antagonists, such as warfarin, are commonly used oral anticoagulants for treating and preventing thromboembolic diseases. Understanding the mechanistic actions of these drugs at the cellular and structural levels is crucial for addressing their limitations and improving anticoagulation strategies targeting the vitamin K cycle.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Medicine, General & Internal
Han Yan, Yi Chen, Hong Zhu, Wei-Hua Huang, Xin-He Cai, Dan Li, Ya-Juan Lv, Si-Zhao, Hong-Hao Zhou, Fan-Yan Luo, Wei Zhang, Xi Li
Summary: The vitamin K antagonist is a commonly prescribed oral anticoagulant with varying dose requirements for different patients. Recent studies suggest a potential relationship between the intestinal microbiome and the vitamin K antagonist, where antibiotics use may increase bleeding risk. Further research is needed to explore how the intestinal bacteria affect the response of the vitamin K antagonist.
FRONTIERS IN MEDICINE
(2022)
Review
Nutrition & Dietetics
Marta Zieminska, Beata Sieklucka, Krystyna Pawlak
Summary: Vitamin K and vitamin D deficiency in chronic kidney disease can lead to impaired bone health and increased risk of fractures. Currently, there is no consensus on the optimal supplementation approach for these vitamins in CKD patients.
Article
Medicine, Research & Experimental
Francisca Beato, Dayana Reveron, Kaleena B. Dezsi, Antonio Ortiz, Joseph O. Johnson, Dung-Tsa Chen, Karla Ali, Sean J. Yoder, Daniel Jeong, Mokenge Malafa, Pamela Hodul, Kun Jiang, Barbara A. Centeno, Mahmoud A. Abdalah, Jodi A. Balasi, Alexandra F. Tassielli, Bhaswati Sarcar, Jamie K. Teer, Gina M. DeNicola, Jennifer B. Permuth, Jason B. Fleming
Summary: This study successfully established patient-derived organoids from IPMNs, providing new opportunities to study these lesions and aid in the development of early detection and prevention strategies.
LABORATORY INVESTIGATION
(2021)
Article
Cell Biology
Yun Pyo Kang, Andrea Mockabee-Macias, Chang Jiang, Aimee Falzone, Nicolas Prieto-Farigua, Everett Stone, Isaac S. Harris, Gina M. DeNicola
Summary: Cysteine plays a crucial role in maintaining cellular redox homeostasis and protecting against ferroptosis. Deprivation of cysteine leads to the unexpected accumulation of g-glutamyl-peptides in non-small-cell lung cancer cell lines as a protective mechanism against ferroptosis.
Review
Oncology
Paloma Gonzalez-Sanchez, Gina M. DeNicola
Summary: The human microbiome plays a crucial role in host physiological processes, and increasing evidence suggests its influence on cancer development and treatment response. Besides the gut, organs like the skin, vagina, and lungs harbor their own unique microbiomes. The organ-specific microbiome can contribute to carcinogenesis through mechanisms such as toxin release, immune response alteration, and nutrient level regulation.
JOURNAL OF PATHOLOGY
(2021)
Review
Pharmacology & Pharmacy
Laura Torrente, Gina M. DeNicola
Summary: The transcription factor NRF2 plays a crucial role in regulating cytoprotection and metabolism. Its transient activation in healthy tissues prevents cancer initiation, but cancer cells hijack NRF2 to support their proliferation and develop resistance to treatment. Blocking NRF2 activity in tumors is a promising approach to counteract cancer progression and overcome treatment resistance.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Gina M. DeNicola, David B. Shackelford
Summary: Lung cancer is a heterogeneous disease with histopathological subtypes that have distinct features and molecular alterations affecting tumor metabolism. The tumor metabolism can be influenced by microenvironmental factors and technological advances allow for direct evaluation of metabolic alterations in patient tumors. Molecular alterations also play a role in tumor cell metabolism and can affect response to therapy. Therapeutic approaches targeting tumor metabolism are currently in development for patient therapy.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Article
Oncology
Shengchen Lin, Yunzhan Li, Dezhen Wang, Chongbiao Huang, David Marino, Oana Bollt, Chaodong Wu, Matthew D. Taylor, Wei Li, Gina M. DeNicola, Jihui Hao, Pankaj K. Singh, Shengyu Yang
Summary: Fascin, a pro-metastatic actin-bundling protein, promotes cancer cell migration and invasion by increasing glycolysis in lung cancer through activation of yes-associated protein 1 (YAP1). The fascin-YAP1-PFKFB3 axis is likely conserved across different types of cancers, and pharmacological inhibitors of fascin may be used to reprogram cancer metabolism in lung and potentially other cancers with fascin upregulation.
Editorial Material
Oncology
Sang Jun Yoon, Gina M. DeNicola
Summary: IL1 receptor accessory protein suppresses anoikis in Ewing sarcoma by promoting the activity of the system X-c-cystine/glutamate antiporter and cystathionine gamma-lyase (CTH) transcription to sustain cysteine levels for reactive oxygen species detoxification.
Article
Oncology
Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj K. Singh, Nadine Hempel, Mohamed Trebak, Gina M. DeNicola, Jihui Hao, Shengyu Yang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease with few effective treatments. Activating the Keap1-Nrf2 antioxidant program promotes migration, invasion, metastasis, and metabolic stress resistance in PDAC. The cystine transporter SLC7A11 is identified as a druggable target downstream of the MCU-Nrf2 axis.
Article
Biochemistry & Molecular Biology
Nicol Mecozzi, Arianna Nenci, Olga Vera, Ilah Bok, Aimee Falzone, Gina M. DeNicola, Florian A. Karreth
Summary: Circular RNAs (circRNAs) are a class of non-coding RNAs that play important roles in biological processes. However, studying the functions of circRNAs can be challenging due to limitations of traditional approaches. This study developed genetic tools for stable circRNA overexpression and demonstrated their applications in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Chang Jiang, Nathan P. Ward, Nicolas Prieto-Farigua, Yun Pyo Kang, Anish Thalakola, Mingxiang Teng, Gina M. DeNicola
Summary: The redox regulator NRF2 is hyperactivated in a large percentage of non-small cell lung cancer (NSCLC) cases, which is associated with chemotherapy and radiation resistance. In this study, the researchers identified that the loss of mitochondrial superoxide dismutase 2 (SOD2) enhanced the effectiveness of a superoxide-generating drug, beta-Lapachone. They also found that inhibiting mitochondrial electron transport activity sensitized cells to beta-Lapachone. These findings suggest potential therapeutic strategies to increase ROS sensitivity in NSCLC.
Article
Oncology
Mirunalini Ravichandran, Jingjie Hu, Charles Cai, Nathan P. Ward, Anthony Venida, Callum Foakes, Miljan Kuljanin, Annan Yang, Connor J. Hennessey, Yang Yang, Brandon R. Desousa, Gilles Rademaker, Annelot A. L. Staes, Zeynep Cakir, Isha H. Jain, Andrew J. Aguirre, Joseph D. Mancias, Yin Shen, Gina M. DeNicola, Rushika M. Perera
Summary: The mechanisms of metabolic adaptation of pancreatic ductal adenocarcinoma cells to pharmacologic inhibition of RAS-MAPK signaling are not well understood. This study reveals that the MEK inhibitor trametinib leads to downregulation of c-MYC and increased MiT/TFE-dependent lysosome biogenesis in PDA cells. Furthermore, it is found that increased ferritinophagy promotes mitochondrial iron-sulfur cluster protein synthesis and enhanced mitochondrial respiration. Inhibition of iron utilization sensitizes PDA cells to MEKi.
Article
Multidisciplinary Sciences
Aidan T. Pezacki, Carson D. Matier, Xingxing Gu, Eric Kummelstedt, Sarah E. Bond, Laura Torrente, Kelly L. Jordan-Sciutto, Gina M. DeNicola, Timothy A. Su, Donita C. Brady, Christopher J. Chang
Summary: This study presents an activity-based sensing strategy for the specific detection of Cu(II) through metal-directed acyl imidazole chemistry. The method enables the detection and analysis of labile Cu(II) pools, providing valuable information on its regulation and potential role in metal-dependent diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
S. Branden Van Oss, Saurin Bipin Parikh, Nelson Castilho Coelho, Aaron Wacholder, Ivan Belashov, Sara Zdancewicz, Manuel Michaca, Jiazhen Xu, Yun Pyo Kang, Nathan P. Ward, Sang Jun Yoon, Katherine M. McCourt, Jake McKee, Trey Ideker, Andrew P. VanDemark, Gina M. DeNicola, Anne-Ruxandra Carvunis
Summary: Organisms must synthesize or assimilate essential organic compounds to survive. Met15 has long been considered an essential gene for inorganic sulfur assimilation in yeast. However, our study reveals that the gene YLL058W can also enable cells to assimilate enough inorganic sulfur for survival. This finding has implications for sulfur metabolism research and other related fields.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Oncology
Eva J. Ge, Ashley I. Bush, Angela Casini, Paul A. Cobine, Justin R. Cross, Gina M. DeNicola, Q. Ping Dou, Katherine J. Franz, Vishal M. Gohil, Sanjeev Gupta, Stephen G. Kaler, Svetlana Lutsenko, Vivek Mittal, Michael J. Petris, Roman Polishchuk, Martina Ralle, Michael L. Schilsky, Nicholas K. Tonks, Linda T. Vahdat, Linda Van Aelst, Dan Xi, Peng Yuan, Donita C. Brady, Christopher J. Chang
Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.
NATURE REVIEWS CANCER
(2022)
