Article
Chemistry, Multidisciplinary
Wei-Hsu Chen, Taiki Onoe, Masao Kamimura
Summary: A novel biodegradable/photothermal polymer micelle-based remote-activation method was developed to study the temperature-sensitive ion channel TRPV1. The ICG-micelles showed biocompatibility and biodegradability, with excellent photothermal effects and NIR emission under tissue-penetrable near-infrared laser irradiation. They effectively bound TRPV1 on cell membranes and induced Ca2+ ion influx into neuronal cells under NIR irradiation, suggesting their potential as a noninvasive remote-activation tool for neuronal cells.
Article
Biochemistry & Molecular Biology
Gayoung Jo, Eun Jeong Kim, Min Ho Park, Hoon Hyun
Summary: In this study, a tumor-targetable NIR fluorophore conjugate with rapid body clearance was developed for accurate tumor imaging and effective photothermal therapy. The conjugate showed high tumor accumulation and rapid background clearance, and its photothermal energy induced necrotic cell death in the targeted tumor site.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shengliang Li, Xiangquan Deng, Hui Cheng, Xiaozhen Li, Yingpeng Wan, Chen Cao, Jie Yu, Ying Liu, Yi Yuan, Ke Wang, Chun-Sing Lee
Summary: Researchers have developed a designed and synthesized fluorescent molecule (OFET) for in vivo mouse brain imaging using three-photon microscopy. The OFET molecule, integrated as water dispersible nanoparticles (OFET NPs), has high fluorescence brightness and maximum emission at 820 nm. Under 1720 nm excitation, OFET NPs exhibit a large three-photon action crosssection, more than twice that of commonly used SR101 dye. With the advantages of long excitation and emission wavelength, and high tissue penetration depth, OFET NPs show good deep-brain imaging performance.
Article
Chemistry, Multidisciplinary
Yinying Pu, Haohao Yin, Caihong Dong, Huijing Xiang, Wencheng Wu, Bangguo Zhou, Dou Du, Yu Chen, Huixiong Xu
Summary: A sono-controllable and ROS-sensitive nanomedicine, P/M@CasMTH1, has been developed for enhanced sonodynamic therapy by disrupting MTH1 gene in tumor cells, leading to cellular apoptosis and tumor suppression.
ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Yating Xu, Biao Chen, Deliang Su, Jianqing Li, Qiang Qi, Yuxin Hu, Quan Wang, Fan Xia, Xiaoding Lou, Zujin Zhao, Jun Dai, Xiyuan Dong, Jian Zhou
Summary: This study proposes a valuable strategy to design NIR polymeric photosensitizers with enhanced photothermal conversion efficiency and strong NIR absorbance by inserting TPA-AQ as a thermally activated delayed fluorescence unit into a polymeric backbone. The experimental results show that PEKB-244 with the appropriate molar content of the TPA-AQ unit exhibits the strongest NIR absorbance and the highest photothermal conversion efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Fei Duan, Wei Jin, Tong Zhang, Yuanzi Sun, Xuliang Deng, Weiping Gao
Summary: The study introduces a thermo-pH-sensitive polymer-glucose oxidase conjugate that can self-assemble into nanoparticles with improved stability for cancer therapy. By adjusting the solution temperature and pH, the conjugate's size, surface charge, and bioactivity can be tuned. Under the acidic tumor microenvironment, the conjugate exhibits enhanced cellular uptake, intracellular hydrogen peroxide generation, and tumor cell spheroid penetration, leading to increased cytotoxicity to tumor cells. The conjugate also induces a robust antitumor immunity and selectively eradicates tumors without perceivable side effects.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Inorganic & Nuclear
Mengyao Su, Zhimin Wang, Jiatao Zhang
Summary: Precisely regulating temperature-sensitive transient receptor potential ion channels (Thermo-TRPs) is crucial for understanding their biochemical effects and potential therapeutic applications. Current strategies, such as chemical perturbation and genetic engineering, face challenges in terms of invasiveness and low spatiotemporal resolution. The emerging optical control technology, utilizing near-infrared (NIR) photothermal nanomaterials, shows promise for noninvasive and deep-tissue operation of Thermo-TRPs. This review focuses on the recent developments in NIR photothermal nanotransducers for precise modulation of Thermo-TRPs, including biological classification, gating mechanisms, and neuronal activation.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Siyu Chen, Xiaoying Wang, Minghui Lin, Yingke Hou, Mengbin Ding, Deping Kong, Haitao Sun, Qin Zhang, Jingchao Li, Quan Zhou
Summary: A pH-sensitive second near-infrared photothermal liposomal nanocomplex has been developed for enhanced NK cell-based immunotherapy of breast cancer. The nanocomplex effectively inhibits tumor growth and prevents lung metastasis, offering a promising approach for effective and precise treatment of cancer.
APPLIED MATERIALS TODAY
(2021)
Review
Biotechnology & Applied Microbiology
Qing Cai, Zuntai Li, Baosheng Li, Jiayang Jiang, Xiaoyu Li, Weiyan Meng, Shoujun Zhu
Summary: Near-infrared (NIR) bioimaging, especially in the NIR-II region, provides higher sensitivity and spatiotemporal resolution compared to traditional radiography, offering potential for both diagnosis and treatment of bone diseases. Targeted bone imaging and photoX therapy using NIR probes show promise in enhancing treatment efficiency for bone tumors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Jingwei Pan, Jianjun Du, Qiao Hu, Yuan Liu, Xiaoxue Zhang, Xin Li, Danhong Zhou, Qichao Yao, Saran Long, Jiangli Fan, Xiaojun Peng
Summary: Photothermal therapy (PTT) is a promising approach to cancer treatment. The photothermal conversion ability of Cy7 is efficiently enhanced based on photo-induced electron transfer (PET)-triggered structural deformation. Three Cy7 derivatives, CZ-Cy7, PXZ-Cy7, and PTZ-Cy7, are presented as examples to demonstrate the regulation of the energy release of the excited states.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Mojtaba Mansoorianfar, Zahid Hussain, Arash Simchi, Yi Cao, Ismat Ullah, Salim Ullah
Summary: This study developed bandgap-modified nanoparticles for combined diagnosis and therapy of cancer. The nanoparticles enable targeted photothermal therapy and dual imaging, improving efficiency and minimizing damage to adjacent normal tissues.
APPLIED MATERIALS TODAY
(2023)
Review
Oncology
Junling Chen, Minglin Zhang, Zhiyuan Ma, Dumin Yuan, Jiaxing Zhu, Biguang Tuo, Taolang Li, Xuemei Liu
Summary: Hypoxia plays a significant role in the development of gastric cancer, while ion channels/transporters (ICTs) also have an important impact on regulating tumor cell activities. Targeting the hypoxic microenvironment and ICTs may be a promising strategy for the treatment of gastric cancer.
Review
Polymer Science
Chaoqun Li, Dong Gao, Boying Li, Xiaoning Liu, Ran Zhang, Chengfen Xing
Summary: This review summarizes the application of near-infrared (NIR) responsive materials in ion channel regulation and elucidates their action mechanism in regulating ion channel-related diseases. It is hoped that this review can provide foundation for future research on light-stimulated materials, promote their application in biomedical engineering, and be useful for clinical disease treatment.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Miao Zhao, Edward Leggett, Struan Bourke, Souzana Poursanidou, Sadie Carter-Searjeant, Steve Po, Marciano Palma do Carmo, Lea Ann Dailey, Philip Manning, Sean G. Ryan, Laura Urbano, Mark A. Green, Aliaksandra Rakovich
Summary: Conjugated polymer nanoparticles (CPNs) based on PTB7 were prepared and evaluated for their potential in theranostic applications involving bioimaging and photosensitization. The CPNs showed efficient NIR-I transparency for bioimaging and demonstrated photosensitizing capabilities in both aqueous solutions and cell cultures. The photosensitizing ability of CPNs was found to be influenced by the stabilizing shell material, with Pluronic F-127 leading to enhanced ROS production and poly[styrene-co-maleic anhydride] completely quenching the process.
Article
Chemistry, Multidisciplinary
Qing Liu, Hong-Bo Cheng, Rui Ma, Mingming Yu, Yuanyu Huang, Lele Li, Jian Zhao
Summary: A near-infrared light-guided DNA nanodevice is developed for precise drug delivery and tumor therapy. The nanodevice consists of GC-rich DNA duplexes with a UV light labile moiety and upconversion nanoparticles. Upon NIR light irradiation, the nanoparticles emit UV light to break the pho-tolabile moiety, resulting in controlled drug release and fluorescence signal recovery. This modular strategy enables remotely controlled drug delivery and in situ imaging.