Article
Chemistry, Multidisciplinary
Gerrit Bredeck, Angela A. M. Kaempfer, Adriana Sofranko, Tina Wahle, Veronika Buettner, Catrin Albrecht, Roel P. F. Schins
Summary: The study found that engineered nanomaterials have both shared and specific effects on intestinal mucin expression, with CeO2 downregulating MUC1 and Ag downregulating Muc2. Data from advanced in vitro models were consistent with mouse models, indicating higher relevance for hazard assessment.
Review
Pharmacology & Pharmacy
Rachel L. Shapiro, Kevin DeLong, Fareeha Zulfiqar, Davell Carter, Marina Better, Laura M. Ensign
Summary: Vaginal drug delivery systems are preferred for treating female reproductive tract diseases with fewer systemic side effects, but face anatomical and biological barriers. In vitro and ex vivo models are crucial for evaluating these systems. Advanced model systems for other mucosa can inspire future development for the female reproductive tract.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Yujie Wang, Rong Wen, Dongdong Liu, Chen Zhang, Zhuo A. Wang, Yuguang Du
Summary: Chitosan oligosaccharide has been shown to have a protective effect on intestinal mucus in inflammatory bowel disease, improving DSS-induced mucus defects, with its structural characteristics playing a key role in this activity.
Review
Pharmacology & Pharmacy
Nicole A. Bustos, Katharina Ribbeck, Caroline E. Wagner
Summary: Mucus is a biological hydrogel that protects wet epithelial surfaces. Mucins, the main components of mucus, play a critical role in protecting against invading pathogens and modulating disease transmission. Understanding the interactions between pathogens and mucins is essential for comprehending disease transmission and early stages of infection.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biochemical Research Methods
Hannah L. Viola, Vishwa Vasani, Kendra Washington, Ji-Hoon Lee, Cauviya Selva, Andrea Li, Carlos J. Llorente, Yoshinobu Murayama, James B. Grotberg, Francesco Romano, Shuichi Takayama
Summary: This paper introduces a lung-on-a-chip device with semi-circular cross-section microchannels and computer-controlled fluidic switching that enables a broader systematic investigation of liquid plug dynamics in a manner relevant to the distal airways. The device allows stable generation and propagation of liquid plugs, captures plug speed, length, and pressure drop, and is significant in studying lung diseases.
Article
Engineering, Biomedical
Patrick Knoll, Nguyet-Minh Nguyen Le, Richard Wibel, Randi Angela Baus, Gergely Kali, Mulazim Hussain Asim, Andreas Bernkop-Schnuerch
Summary: Three generations of thiolated polymers have been developed with different thiol ligands to enhance mucus interactions. This study synthesized all three generations on a pectin backbone for the first time, with third generation showing superior mucoadhesive properties. Additionally, the polymers did not exhibit cytotoxicity, indicating potential applications in drug delivery systems.
ACTA BIOMATERIALIA
(2021)
Article
Food Science & Technology
Yangli Wan, Liu Yang, Qianhong Li, Xiaowen Wang, Ting Zhou, Dishi Chen, Li Li, Yeru Wang, Xin Wang
Summary: This study analyzed the thermal stability of food poisoning Staphylococcus aureus (S. aureus) enterotoxin-like X (SElX) and the biological characteristics of digestive enzymes. The results showed that SElX had significant resistance to heat treatment and digestion by pepsin. It also exhibited strong superantigen and emetic activities, but no lethal effect on mice and no significant toxicity to cells. Importantly, SElX was found to have an inhibitory effect on acidic mucus of goblet cells in various segments of the small intestine.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ellaine Salvador, Almuth F. Kessler, Dominik Domroese, Julia Hoermann, Clara Schaeffer, Aiste Giniunaite, Malgorzata Burek, Catherine Tempel-Brami, Tali Voloshin, Alexandra Volodin, Adel Zeidan, Moshe Giladi, Ralf-Ingo Ernestus, Mario Loehr, Carola Y. Foerster, Carsten Hagemann
Summary: This study reports on the effects of Tumor Treating Fields (TTFields) on the integrity and permeability of the blood-brain barrier (BBB). The study demonstrates that TTFields can transiently disrupt the BBB and improve drug delivery.
Article
Chemistry, Multidisciplinary
Reena Jatyan, Deepak Kumar Sahel, Prabhjeet Singh, Rajeev Sakhuja, Anupama Mittal, Deepak Chitkara
Summary: In this study, the conjugation of fatty acids with temozolomide improved its anticancer potential against glioblastoma multiforme. The synthesized conjugates showed a stronger inhibitory effect on tumor cells in vitro and improved survival rate in an animal model.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Shahar Shelly, Sigal Liraz Zaltsman, Ofir Ben-Gal, Avraham Dayan, Ithamar Ganmore, Chen Shemesh, Dana Atrakchi, Sharif Garra, Orly Ravid, Daniel Rand, Hila Israelov, Tayir Alon, Gabriel Lichtenstein, Shirley Sharabi, David Last, Fabien Gosselet, Vasiliy Rosen, Gideon Burstein, Alon Friedlander, Ran Harel, Guy Vogel, Michal Schnaider Beeri, Yael Mardor, Yair Lampl, Gideon Fleminger, Itzik Cooper
Summary: Studies have shown that high levels of titanium may accumulate in the human body adjacent to orthopedic implants, and it may have neurotoxic effects.
Article
Oncology
Mohamed Badawi, Rajeev Menon, Andrew E. Place, Tammy Palenski, Gauri Sunkersett, Richard Arrendale, Rong Deng, Sara M. Federico, Todd M. Cooper, Ahmed Hamed Salem
Summary: Infiltration of malignant cells into the central nervous system is associated with poor clinical outcomes in hematological malignancies. Limited investigations have been conducted on the penetration of venetoclax into the central nervous system. This study demonstrates the ability of venetoclax to cross into the central nervous system and provides evidence of its potential role in improving clinical outcomes for patients with CNS complications.
Article
Biochemistry & Molecular Biology
Hanjun Zhao, Chuyuan Zhang, Hoiyan Lam, Xinjie Meng, Zheng Peng, Man Lung Yeung, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Kwok-Yung Yuen
Summary: It has been found that the specially designed SARS-CoV-2 and influenza defective interfering genes (DIGs) can significantly inhibit the replication of corresponding viruses. Through the gene delivery vector TAT2-P1&LAH4, DIGs can be effectively delivered in the lungs to inhibit the replication of SARS-CoV-2 variants and influenza virus.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yun-Mi Kang, Hye-Min Kim, Minho Lee, Hyo-Jin An
Summary: Oleanolic acid (OA) exhibits anti-atopic effects by suppressing AD-like lesions and regulating inflammatory mediators, suggesting its potential as a therapeutic agent for allergic disorders such as atopic dermatitis (AD). The inhibitory effects of OA on Th2 cytokines and chemokines in AD mouse model and keratinocytes were mediated through blocking the activation of key signaling pathways. These findings provide novel insights into the pharmacological targets of OA for treating AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Raleigh M. Linville, Alexander Komin, Xiaoyan Lan, Jackson G. DeStefano, Chengyan Chu, Guanshu Liu, Piotr Walczak, Kalina Hristova, Peter C. Searson
Summary: Melittin, a membrane active peptide found in bee venom, enables transient blood-brain barrier opening for delivery of therapeutics into the brain. Studies on endothelial and neuronal viability identified the effective concentration range for BBB opening, and a tissue-engineered model was used to optimize dosing and understand the mechanism. Melittin and other membrane active variants increase paracellular permeability temporarily by disrupting cell-cell junctions.
Article
Biochemistry & Molecular Biology
Ruiyu Zhu, Shuo Shan, Su Zhou, Zhen Chen, Yuanfeng Wu, Wei Liao, Chao Zhao, Qiang Chu
Summary: In this study, Saccharomyces cerevisiae KD was used to efficiently degrade patulin and alleviate the biotoxicity caused by patulin. The results showed that Saccharomyces cerevisiae KD could effectively degrade patulin, reduce oxidative stress and intestinal damage. Furthermore, Saccharomyces cerevisiae KD could regulate gene expression levels to control the ROS level and GSH content, thus decreasing intestinal damage.
