P. edulis Extract Protects Against Amyloid-β Toxicity in Alzheimer’s Disease Models Through Maintenance of Mitochondrial Homeostasis via the FOXO3/DAF-16 Pathway

Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

(2022) Chenglong Xie et al.   Nature Biomedical Engineering

Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy

(2021) Asgeir Kobro-Flatmoen et al.   AGEING RESEARCH REVIEWS

Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway

(2021) Yalun Zhang et al.   BRAIN

Neuronal DAF-16-to-intestinal DAF-16 communication underlies organismal lifespan extension in C. elegans

(2021) Masaharu Uno et al.   iScience

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

(2021) Michael J. Munson et al.   Nature Communications

Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

(2020) Na Zhao et al.   NEURON

Passion fruit (Passiflora edulis) leaf aqueous extract ameliorates intestinal epithelial barrier dysfunction and reverts inflammatory parameters in Caco-2 cells monolayer

(2020) Mônica Cristina Lopes do Carmo et al.   FOOD RESEARCH INTERNATIONAL

Baru Pulp (Dipteryx alata Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of Caenorhabditis elegans via SOD-3 and DAF-16

(2020) Natasha Rios Leite et al.   Biomolecules

Novel amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity

(2020) Christian Gallrein et al.   PROGRESS IN NEUROBIOLOGY

Clove essential oil confers antioxidant activity and lifespan extension in C. elegans via the DAF-16/FOXO transcription factor

(2020) Lianfeng Zhang et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Turning up mitophagy in Alzheimer disease

(2019) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

(2019) Edward F. Griffin et al.   Disease Models & Mechanisms

Impact of in vitro gastrointestinal digestion on the bioaccessibility and antioxidant capacity of bioactive compounds from Passion fruit ( Passiflora edulis ) leaves and juice extracts

(2019) Johanny Aguillón‐Osma et al.   JOURNAL OF FOOD BIOCHEMISTRY

Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila

(2019) James P. Higham et al.   Frontiers in Cellular Neuroscience

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

(2018) Nadia Cummins et al.   EMBO JOURNAL

Tropical fruit by-products water extracts as sources of soluble fibres and phenolic compounds with potential antioxidant, anti-inflammatory, and functional properties

(2018) Marcela Albuquerque Cavalcanti de Albuquerque et al.   Journal of Functional Foods

A new C-glycosyl flavone and a new neolignan glycoside from Passiflora edulis Sims peel

(2017) Yue Hu et al.   NATURAL PRODUCT RESEARCH

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

Passiflora actiniahydroalcoholic extract and its major constituent, isovitexin, are neuroprotective against glutamate-induced cell damage in mice hippocampal slices

(2016) Kely Cristina dos Santos et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Zinc Improves Cognitive and Neuronal Dysfunction During Aluminium-Induced Neurodegeneration

(2016) Neha Singla et al.   MOLECULAR NEUROBIOLOGY

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

The neuroprotective properties of a novel variety of passion fruit

(2016) Yael Tal et al.   Journal of Functional Foods

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

Blood–brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery

(2015) William M Pardridge   EXPERT OPINION ON THERAPEUTIC TARGETS

The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators

(2015) Rachel Kaletsky et al.   NATURE

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Linking Aβ42-Induced Hyperexcitability to Neurodegeneration, Learning and Motor Deficits, and a Shorter Lifespan in an Alzheimer’s Model

(2015) Yong Ping et al.   PLoS Genetics

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Odor potency, aroma profile and volatiles composition of cold pressed oil from industrial passion fruit residues

(2014) Karina M.M. Leão et al.   INDUSTRIAL CROPS AND PRODUCTS

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Mitochondrial dysfunction, oxidative stress and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson’s model

(2014) A Ray et al.   Cell Death & Disease

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

A synaptic DEG/ENaC ion channel mediates learning in C. elegans by facilitating dopamine signalling

(2008) Giannis Voglis et al.   EMBO JOURNAL

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosa Suppresses Host Immunity by Activating the DAF-2 Insulin-Like Signaling Pathway in Caenorhabditis elegans

(2008) Eric A. Evans et al.   PLoS Pathogens