Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression
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Title
Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression
Authors
Keywords
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Journal
MOLECULAR CANCER THERAPEUTICS
Volume 21, Issue 8, Pages 1261-1272
Publisher
American Association for Cancer Research (AACR)
Online
2022-08-02
DOI
10.1158/1535-7163.mct-21-0984
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- Regulation of the Immune Response by the Aryl Hydrocarbon Receptor
- (2018) Cristina Gutiérrez-Vázquez et al. IMMUNITY
- The Aryl Hydrocarbon Receptor and Tumor Immunity
- (2018) Ping Xue et al. Frontiers in Immunology
- The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment
- (2018) Rahul Shinde et al. TRENDS IN IMMUNOLOGY
- AHR Function in Lymphocytes: Emerging Concepts
- (2016) Liang Zhou TRENDS IN IMMUNOLOGY
- Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner
- (2015) Rikke B. Holmgaard et al. Cell Reports
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- (2014) Zhong-Ze Fang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Ligand Promiscuity of Aryl Hydrocarbon Receptor Agonists and Antagonists Revealed by Site-Directed Mutagenesis
- (2014) A. A. Soshilov et al. MOLECULAR AND CELLULAR BIOLOGY
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- An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
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- (2008) Francisco J. Quintana et al. NATURE
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