FabT, a Bacterial Transcriptional Repressor That Limits Futile Fatty Acid Biosynthesis

The Enterococcus faecalis FabT Transcription Factor Regulates Fatty Acid Biosynthesis in Response to Exogeneous Fatty Acids

(2022) Qi Zou et al.   Frontiers in Microbiology

(p)ppGpp/GTP and Malonyl-CoA Modulate Staphylococcus aureus Adaptation to FASII Antibiotics and Provide a Basis for Synergistic Bi-Therapy

(2021) Amit Pathania et al.   mBio

Type II Fatty Acid Synthesis Pathway and Cyclopropane Ring Formation Are Dispensable during Enterococcus faecalis Systemic Infection

(2021) Constantin Hays et al.   JOURNAL OF BACTERIOLOGY

The Escherichia coli FadR transcription factor: Too much of a good thing?

(2020) John E. Cronan   MOLECULAR MICROBIOLOGY

The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism

(2020) Elisabeth Reithuber et al.   mBio

Conserved and specific features of Streptococcus pyogenes and Streptococcus agalactiae transcriptional landscapes

(2019) Isabelle Rosinski-Chupin et al.   BMC GENOMICS

Enterococcus faecalis Encodes an Atypical Auxiliary Acyl Carrier Protein Required for Efficient Regulation of Fatty Acid Synthesis by Exogenous Fatty Acids

(2019) Lei Zhu et al.   mBio

Structural insights into repression of the Pneumococcal fatty acid synthesis pathway by repressor FabT and co‐repressor acyl‐ACP

(2019) Gang Zuo et al.   FEBS LETTERS

A fatty acid-binding protein of Streptococcus pneumoniae facilitates the acquisition of host polyunsaturated fatty acids

(2019) Jessica M. Gullett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Permissive Fatty Acid Incorporation Promotes Staphylococcal Adaptation to FASII Antibiotics in Host Environments

(2019) Gérald Kénanian et al.   Cell Reports

Interrelationships between Fatty Acid Composition, Staphyloxanthin Content, Fluidity, and Carbon Flow in the Staphylococcus aureus Membrane

(2018) Kiran Tiwari et al.   MOLECULES

Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus

(2018) Laura Devaux et al.   PLoS Genetics

Resilience of small intestinal beneficial bacteria to the toxicity of soybean oil fatty acids

(2018) Sara C Di Rienzi et al.   eLife

MarR Family Transcription Factors from Burkholderia Species: Hidden Clues to Control of Virulence-Associated Genes

(2018) Ashish Gupta et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Relevance of spontaneousfabTmutations to a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-typeStreptococcus pyogenesisolates that lost asalRK

(2016) Ichiro Tatsuno et al.   APMIS

Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis

(2016) Jesus M. Eraso et al.   INFECTION AND IMMUNITY

Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials

(2016) Claire Morvan et al.   Nature Communications

The Response Regulator YycF Inhibits Expression of the Fatty Acid Biosynthesis Repressor FabT in Streptococcus pneumoniae

(2016) Maria L. Mohedano et al.   Frontiers in Microbiology

The Biofilm Lifestyle Involves an Increase in Bacterial Membrane Saturated Fatty Acids

(2016) Florence Dubois-Brissonnet et al.   Frontiers in Microbiology

Incorporation of Exogenous Fatty Acids Protects Enterococcus faecalis from Membrane-Damaging Agents

(2014) Holly E. Saito et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Streptococcus pyogenes Polymyxin B-Resistant Mutants Display Enhanced ExPortal Integrity

(2014) G. C. Port et al.   JOURNAL OF BACTERIOLOGY

Regulation of fatty acid biosynthesis by the global regulator CcpA and the local regulator FabT inStreptococcus mutans

(2014) R.C. Faustoferri et al.   Molecular Oral Microbiology

Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences

(2014) W. Nasser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inefficient Translation Renders the Enterococcus faecalis fabK Enoyl-Acyl Carrier Protein Reductase Phenotypically Cryptic

(2013) H. Bi et al.   JOURNAL OF BACTERIOLOGY

Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus

(2013) Daniela Albanesi et al.   PLoS Pathogens

Transcriptional Regulation of Fatty Acid Biosynthesis in Lactococcus lactis

(2012) T. H. Eckhardt et al.   JOURNAL OF BACTERIOLOGY

Involvement of WalK (VicK) phosphatase activity in setting WalR (VicR) response regulator phosphorylation level and limiting cross-talk inStreptococcus pneumoniaeD39 cells

(2012) Kyle J. Wayne et al.   MOLECULAR MICROBIOLOGY

Serine/Threonine Protein Kinase Stk Is Required for Virulence, Stress Response, and Penicillin Tolerance in Streptococcus pyogenes

(2011) Julia Bugrysheva et al.   INFECTION AND IMMUNITY

Induction of Fatty Acid Composition Modifications and Tolerance to Biocides inSalmonella entericaSerovar Typhimurium by Plant-Derived Terpenes

(2010) Florence Dubois-Brissonnet et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Novel Role of Malonyl-ACP in Lipid Homeostasis,

(2010) Mariano A. Martinez et al.   BIOCHEMISTRY

Acyl-Acyl Carrier Protein Regulates Transcription of Fatty Acid Biosynthetic Genes via the FabT Repressor inStreptococcus pneumoniae

(2009) Agoston Jerga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

(2009) Sophie Brinster et al.   NATURE

Transcriptional regulation in bacterial membrane lipid synthesis: TABLE 1.

(2008) Yong-Mei Zhang et al.   JOURNAL OF LIPID RESEARCH

Membrane lipid homeostasis in bacteria

(2008) Yong-Mei Zhang et al.   NATURE REVIEWS MICROBIOLOGY