Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modelling study

Anopheles gambiae Genome Conservation as a Resource for Rational Gene Drive Target Site Selection

(2021) Nace Kranjc et al.   Insects

Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

(2021) John B. Connolly et al.   MALARIA JOURNAL

Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

(2021) Astrid Hoermann et al.   eLife

Malaria-Resistant Mosquitoes (Diptera: Culicidae); The Principle is Proven, But Will the Effectors Be Effective?

(2021) Zach N Adelman et al.   JOURNAL OF MEDICAL ENTOMOLOGY

Modeling impact and cost‐effectiveness of driving‐Y gene drives for malaria elimination in the Democratic Republic of the Congo

(2021) Nawaphan Metchanun et al.   Evolutionary Applications

Toward the Definition of Efficacy and Safety Criteria for Advancing Gene Drive-Modified Mosquitoes to Field Testing

(2020) Stephanie L. James et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes

(2020) Hanno Schmidt et al.   Nature Communications

Broad spectrum immunomodulatory effects of Anopheles gambiae microRNAs and their use for transgenic suppression of Plasmodium

(2020) Shengzhang Dong et al.   PLoS Pathogens

Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility

(2020) Ace R. North et al.   BMC BIOLOGY

Mapping trends in insecticide resistance phenotypes in African malaria vectors

(2020) Penelope A. Hancock et al.   PLOS BIOLOGY

Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae

(2020) Rebeca Carballar-Lejarazú et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vector genetics, insecticide resistance and gene drives: An agent-based modeling approach to evaluate malaria transmission and elimination

(2020) Prashanth Selvaraj et al.   PLoS Computational Biology

Promises and perils of gene drives: Navigating the communication of complex, post-normal science

(2019) Dominique Brossard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malaria eradication within a generation: ambitious, achievable, and necessary

(2019) Richard G A Feachem et al.   LANCET

Reducing malaria burden and accelerating elimination with long-lasting systemic insecticides: a modelling study of three potential use cases

(2019) Prashanth Selvaraj et al.   MALARIA JOURNAL

Investigating the impact of enhanced community case management and monthly screening and treatment on the transmissibility of malaria infections in Burkina Faso: study protocol for a cluster-randomised trial

(2019) Katharine A Collins et al.   BMJ Open

Windborne long-distance migration of malaria mosquitoes in the Sahel

(2019) Diana L. Huestis et al.   NATURE

MGD riv E: A modular simulation framework for the spread of gene drives through spatially explicit mosquito populations

(2019) Héctor M. Sánchez C. et al.   Methods in Ecology and Evolution

Experimental population modification of the malaria vector mosquito, Anopheles stephensi

(2019) Thai Binh Pham et al.   PLoS Genetics

Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group †

(2018) Stephanie James et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Reducing resistance allele formation in CRISPR gene drive

(2018) Jackson Champer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seasonality and heterogeneity of malaria transmission determine success of interventions in high-endemic settings: a modeling study

(2018) Prashanth Selvaraj et al.   BMC INFECTIOUS DISEASES

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

(2018) Kyros Kyrou et al.   NATURE BIOTECHNOLOGY

Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: trends in pyrethroid resistance during a WHO-coordinated multi-country prospective study

(2018)   Parasites & Vectors

Integral gene drives for population replacement

(2018) Alexander Nash et al.   Biology Open

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

(2017) Andrea Beaghton et al.   GENETICS

Population modification of Anopheline species to control malaria transmission

(2017) Rebeca Carballar-Lejarazú et al.   Pathogens and Global Health

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

(2017) Jackson Champer et al.   PLoS Genetics

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

(2017) Andrew M. Hammond et al.   PLoS Genetics

Transgenic Expression of the Anti-parasitic Factor TEP1 in the Malaria Mosquito Anopheles gambiae

(2017) Gloria Volohonsky et al.   PLoS Pathogens

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

(2017) Andrea Beaghton et al.   GENETICS

Overcoming evolved resistance to population-suppressing homing-based gene drives

(2017) John M. Marshall et al.   Scientific Reports

Short-term Impact of Mass Drug Administration With Dihydroartemisinin Plus Piperaquine on Malaria in Southern Province Zambia: A Cluster-Randomized Controlled Trial

(2016) Thomas P. Eisele et al.   JOURNAL OF INFECTIOUS DISEASES

Averting a malaria disaster: will insecticide resistance derail malaria control?

(2016) Janet Hemingway et al.   LANCET

Cheating evolution: engineering gene drives to manipulate the fate of wild populations

(2016) Jackson Champer et al.   NATURE REVIEWS GENETICS

Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics

(2016) Philip A. Eckhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

(2015) S. Bhatt et al.   NATURE

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

(2015) Andrew Hammond et al.   NATURE BIOTECHNOLOGY

Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquitoAnopheles stephensi

(2015) Valentino M. Gantz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of a Field Population of Aedes aegypti in Brazil by Sustained Release of Transgenic Male Mosquitoes

(2015) Danilo O. Carvalho et al.   PLoS Neglected Tropical Diseases

Transgenic Anopheles gambiae Expressing an Antimalarial Peptide Suffer No Significant Fitness Cost

(2014) Clare C. McArthur et al.   PLoS One

Modelling the spatial spread of a homing endonuclease gene in a mosquito population

(2013) Ace North et al.   JOURNAL OF APPLIED ECOLOGY

Landscape Movements of Anopheles gambiae Malaria Vector Mosquitoes in Rural Gambia

(2013) Christopher J. Thomas et al.   PLoS One

Genetic approaches to interfere with malaria transmission by vector mosquitoes

(2013) Sibao Wang et al.   TRENDS IN BIOTECHNOLOGY

Genetic control ofAedesmosquitoes

(2013) Luke Alphey et al.   Pathogens and Global Health

Successful suppression of a field mosquito population by sustained release of engineered male mosquitoes

(2012) Angela F Harris et al.   NATURE BIOTECHNOLOGY

Open Field Release of Genetically Engineered Sterile Male Aedes aegypti in Malaysia

(2012) Renaud Lacroix et al.   PLoS One

Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development

(2012) A. T. Isaacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A malaria transmission-directed model of mosquito life cycle and ecology

(2011) Philip A Eckhoff   MALARIA JOURNAL

Field performance of engineered male mosquitoes

(2011) Angela F Harris et al.   NATURE BIOTECHNOLOGY

Site-Specific Integration and Expression of an Anti-Malarial Gene in Transgenic Anopheles gambiae Significantly Reduces Plasmodium Infections

(2011) Janet M. Meredith et al.   PLoS One

Engineered Anopheles Immunity to Plasmodium Infection

(2011) Yuemei Dong et al.   PLoS Pathogens

Engineered Resistance to Plasmodium falciparum Development in Transgenic Anopheles stephensi

(2011) Alison T. Isaacs et al.   PLoS Pathogens

Activation of Akt Signaling Reduces the Prevalence and Intensity of Malaria Parasite Infection and Lifespan in Anopheles stephensi Mosquitoes

(2010) Vanessa Corby-Harris et al.   PLoS Pathogens