Integral gene drives for population replacement

Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group †

(2018) Stephanie James et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Engineering Introns to Express RNA Guides for Cas9- and Cpf1-Mediated Multiplex Genome Editing

(2018) Dan Ding et al.   Molecular Plant

Reducing resistance allele formation in CRISPR gene drive

(2018) Jackson Champer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consequences of resistance evolution in a Cas9-based sex conversion-suppression gene drive for insect pest management

(2018) Mohammad KaramiNejadRanjbar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

(2018) Kyros Kyrou et al.   NATURE BIOTECHNOLOGY

Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs

(2018) Georg Oberhofer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

(2017) Andrea Beaghton et al.   GENETICS

Incidence and admission rates for severe malaria and their impact on mortality in Africa

(2017) Flavia Camponovo et al.   MALARIA JOURNAL

Genetic diversity of the African malaria vector Anopheles gambiae

(2017) Alistair Miles et al.   NATURE

Inefficient Ribosomal Skipping Enables Simultaneous Secretion and Display of Proteins in Saccharomyces cerevisiae

(2017) Carlos A. Cruz-Teran et al.   ACS Synthetic Biology

Conservation demands safe gene drive

(2017) Kevin M. Esvelt et al.   PLOS BIOLOGY

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

(2017) Jackson Champer et al.   PLoS Genetics

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

(2017) Andrew M. Hammond et al.   PLoS Genetics

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

(2017) Andrea Beaghton et al.   GENETICS

Evolutionary dynamics of CRISPR gene drives

(2017) Charleston Noble et al.   Science Advances

Overcoming evolved resistance to population-suppressing homing-based gene drives

(2017) John M. Marshall et al.   Scientific Reports

Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector

(2017) Ziqing Liu et al.   Scientific Reports

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

(2016) Robert L. Unckless et al.   GENETICS

Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics

(2016) Philip A. Eckhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Mosquito-Borne Infectious Diseases: Sex and Gene Drive

(2016) Zach N. Adelman et al.   TRENDS IN PARASITOLOGY

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

(2016) Robert L. Unckless et al.   GENETICS

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

(2015) Andrew Hammond et al.   NATURE BIOTECHNOLOGY

Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis inAedes aegypti

(2015) Sanjay Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquitoAnopheles stephensi

(2015) Valentino M. Gantz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations

(2015) V. M. Gantz et al.   SCIENCE

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

(2015) Alejandro Rojas-Fernandez et al.   Scientific Reports

CRISPR transcriptional repression devices and layered circuits in mammalian cells

(2014) Samira Kiani et al.   NATURE METHODS

VectorBase: an updated bioinformatics resource for invertebrate vectors and other organisms related with human diseases

(2014) Gloria I. Giraldo-Calderón et al.   NUCLEIC ACIDS RESEARCH

Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster

(2014) Alekos Simoni et al.   NUCLEIC ACIDS RESEARCH

Identification of germline transcriptional regulatory elements in Aedes aegypti

(2014) Omar S. Akbari et al.   Scientific Reports

Optimising Homing Endonuclease Gene Drive Performance in a Semi-Refractory Species: The Drosophila melanogaster Experience

(2013) Yuk-Sang Chan et al.   PLoS One

Optimal temperature for malaria transmission is dramatically lower than previously predicted

(2012) Erin A. Mordecai et al.   ECOLOGY LETTERS

Insect Population Control by Homing Endonuclease-Based Gene Drive: An Evaluation inDrosophila melanogaster

(2011) Yuk-Sang Chan et al.   GENETICS

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

(2011) Nikolai Windbichler et al.   NATURE

Engineered Resistance to Plasmodium falciparum Development in Transgenic Anopheles stephensi

(2011) Alison T. Isaacs et al.   PLoS Pathogens

Cryptococcus neoformans Overcomes Stress of Azole Drugs by Formation of Disomy in Specific Multiple Chromosomes

(2010) Edward Sionov et al.   PLoS Pathogens

The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies

(2009) Philippos A Papathanos et al.   BMC MOLECULAR BIOLOGY

Targeting the X Chromosome during Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae

(2008) Nikolai Windbichler et al.   PLoS Genetics