Deoxytrifluoromethylation of Alcohols

Nontraditional Fragment Couplings of Alcohols and Carboxylic Acids: C(sp3)–C(sp3) Cross-Coupling via Radical Sorting

(2022) Holt A. Sakai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interrupting the Barton–McCombie Reaction: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates

(2021) Zhi-Yun Liu et al.   ORGANIC LETTERS

Copper Catalyzed C(sp3)–H Bond Alkylation via Photoinduced Ligand-to-Metal Charge Transfer

(2021) Sean M. Treacy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metallaphotoredox-enabled deoxygenative arylation of alcohols

(2021) Zhe Dong et al.   NATURE

Iron-Catalyzed Photoinduced LMCT: A 1° C–H Abstraction Enables Skeletal Rearrangements and C(sp3)–H Alkylation

(2021) Yi Cheng Kang et al.   ACS Catalysis

What is in Our Kit? An Analysis of Building Blocks Used in Medicinal Chemistry Parallel Libraries

(2021) Ying Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A biomimetic S H 2 cross-coupling mechanism for quaternary sp 3 -carbon formation

(2021) Wei Liu et al.   SCIENCE

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds

(2020) Benjamin M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source

(2020) Stavros K. Kariofillis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation

(2020) Patrick J. Sarver et al.   Nature Chemistry

Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp2)–C(sp3) Cross-Coupling Methods by Library Synthesis

(2020) Amanda W. Dombrowski et al.   ACS Medicinal Chemistry Letters

Direct C(sp 3 )−H Trifluoromethylation of Unactivated Alkanes Enabled by Multifunctional Trifluoromethyl Copper Complexes

(2020) Geunho Choi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic One-Step Deoxytrifluoromethylation of Alcohols

(2019) Francisco de Azambuja et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Late-Stage Benzylic C(sp3)–H Trifluoromethylation

(2019) Haiwen Xiao et al.   Chem

A Systematic Cheminformatics Analysis of Functional Groups Occurring in Natural Products

(2019) Peter Ertl et al.   JOURNAL OF NATURAL PRODUCTS

Copper-Catalyzed Trifluoromethylation of Alkyl Bromides

(2019) David J. P. Kornfilt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, properties and applications of fluorinated and fluoroalkylated N-containing monosaccharides and their analogues

(2019) Monika Bilska-Markowska et al.   JOURNAL OF FLUORINE CHEMISTRY

Dehydroxylative Trifluoromethylthiolation, Trifluoromethylation, and Difluoromethylation of Alcohols

(2019) Wei Zhang et al.   CHINESE JOURNAL OF CHEMISTRY

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Generation and Alkylation of α-Carbamyl Radicals via Organic Photoredox Catalysis

(2018) Joshua B. McManus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Redox-Neutral Photocatalytic Cyclopropanation via Radical/Polar Crossover

(2018) James P. Phelan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

(2018) Jacob A. Kautzky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organic synthesis provides opportunities to transform drug discovery

(2018) David C. Blakemore et al.   Nature Chemistry

Copper-Catalyzed Reductive Trifluoromethylation of Alkyl Iodides with Togni’s Reagent

(2018) Yanchi Chen et al.   ORGANIC LETTERS

Aqueous Benzylic C–H Trifluoromethylation for Late-Stage Functionalization

(2018) Shuo Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

(2017) Xinqiang Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An algorithm to identify functional groups in organic molecules

(2017) Peter Ertl   Journal of Cheminformatics

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Synthesis of trifluoromethylated compounds from alcohols via alkoxydiphenylphosphines

(2015) Jun-Li Li et al.   JOURNAL OF FLUORINE CHEMISTRY

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

(2014) Erick M. Carreira et al.   CHEMICAL REVIEWS

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

(2013) Pascal Furet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Copper-Mediated Deoxygenative Trifluoromethylation of Benzylic Xanthates: Generation of a CCF3Bond from an O-Based Electrophile

(2013) Lingui Zhu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metabolically Stable tert-Butyl Replacement

(2013) David Barnes-Seeman et al.   ACS Medicinal Chemistry Letters

Photoinduced Ullmann C-N Coupling: Demonstrating the Viability of a Radical Pathway

(2012) S. E. Creutz et al.   SCIENCE

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

(2011) W. Patrick Walters et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

(2010) Nicholas A. McGrath et al.   JOURNAL OF CHEMICAL EDUCATION

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY