Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases

Pharmacological treatment of stable chronic obstructive pulmonary disease

(2021) Dave Singh   RESPIROLOGY

Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)

(2021) Fabio Rancati et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD

(2020) Klaus F. Rabe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Joan B Soriano et al.   Lancet Respiratory Medicine

Topical ‘dual-soft’ glucocorticoid receptor agonist for dermatology

(2020) Kevin N. Dack et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Long-Acting Bronchodilators for Chronic Obstructive Pulmonary Disease

(2020) Alexander G. Mathioudakis et al.   CLINICS IN CHEST MEDICINE

Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel “Dual-Soft” PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis

(2020) Jens Larsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prospects for COPD treatment

(2020) Maria Gabriella Matera et al.   CURRENT OPINION IN PHARMACOLOGY

Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial

(2018) Alberto Papi et al.   LANCET

Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD

(2018) David A. Lipson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

(2018) Mark Bell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry

(2017) Philipp Fronik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Single inhaler triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomised controlled trial

(2016) Dave Singh et al.   LANCET

Discovery of (R)-1-(3-((2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1′-Biphenyl]-2-ylcarbamate (TD-5959, GSK961081, Batefenterol): First-in-Class Dual Pharmacology Multivalent Muscarinic Antagonist and β2 Agonist (MABA) for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)

(2015) Adam D. Hughes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chronic obstructive pulmonary disease

(2015) Peter J. Barnes et al.   Nature Reviews Disease Primers

Bifunctional drugs for the treatment of asthma and chronic obstructive pulmonary disease

(2014) C. Page et al.   EUROPEAN RESPIRATORY JOURNAL

Direct and indirect economic and health consequences of COPD in Denmark: a national register-based study: 1998–2010

(2014) Anders Løkke et al.   BMJ Open

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bridging the gap: bitopic ligands of G-protein-coupled receptors

(2012) J. Robert Lane et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Epidemiology of chronic obstructive pulmonary disease: a literature review

(2012) Catherine Rycroft et al.   International Journal of Chronic Obstructive Pulmonary Disease

Dual-pharmacology muscarinic antagonist and β2agonist molecules for the treatment of chronic obstructive pulmonary disease

(2011) Adam D Hughes et al.   Future Medicinal Chemistry

THRX-198321 Is a Bifunctional Muscarinic Receptor Antagonist and  2-Adrenoceptor Agonist (MABA) That Binds in a Bimodal and Multivalent Manner

(2010) T. Steinfeld et al.   MOLECULAR PHARMACOLOGY

Discovery of Novel Quaternary Ammonium Derivatives of (3R)-Quinuclidinol Esters as Potent and Long-Acting Muscarinic Antagonists with Potential for Minimal Systemic Exposure after Inhaled Administration: Identification of (3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide (Aclidinium Bromide)

(2009) María Prat et al.   JOURNAL OF MEDICINAL CHEMISTRY