Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification

Aconitum alkaloids induce cardiotoxicity and apoptosis in embryonic zebrafish by influencing the expression of cardiovascular relative genes

(2019) Fei Liu et al.   TOXICOLOGY LETTERS

The PI3K/Akt/mTOR signaling pathway plays a role in regulating aconitine-induced autophagy in mouse liver

(2019) Hanqi Yang et al.   RESEARCH IN VETERINARY SCIENCE

C19-Norditerpenoid Alkaloids from Aconitum szechenyianum

(2018) Bei Song et al.   MOLECULES

Aconitum alkaloids, the major components of Aconitum species, affect expression of multidrug resistance-associated protein 2 and breast cancer resistance protein by activating the Nrf2-mediated signalling pathway

(2018) Jin-jun Wu et al.   PHYTOMEDICINE

Human carboxylesterases: a comprehensive review

(2018) Dandan Wang et al.   Acta Pharmaceutica Sinica B

Probing the transcriptome of Aconitum carmichaelii reveals the candidate genes associated with the biosynthesis of the toxic aconitine-type C 19 -diterpenoid alkaloids

(2018) Dake Zhao et al.   PHYTOCHEMISTRY

Sweroside Alleviated Aconitine-Induced Cardiac Toxicity in H9c2 Cardiomyoblast Cell Line

(2018) Li-Qun Ma et al.   Frontiers in Pharmacology

The investigation of allosteric regulation mechanism of analgesic effect using SD rat taste bud tissue biosensor

(2018) Sa Xiao et al.   BIOSENSORS & BIOELECTRONICS

Rapid Determination of Aconitum Alkaloids from Human Urine by UHPLC–HRMS

(2017) Shaohua Li et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

A review of traditional and current methods used to potentially reduce toxicity of Aconitum roots in Traditional Chinese Medicine

(2017) Shuai Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Diterpenoid Alkaloids from Two Aconitum Species with Antifeedant Activity against Spodoptera exigua

(2017) Ji-Fa Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Aconitine: A potential novel treatment for systemic lupus erythematosus

(2017) Xiaodong Li et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Identification of Potential Biomarkers from Aconitum carmichaelii, a Traditional Chinese Medicine, Using a Metabolomic Approach

(2017) Dake Zhao et al.   PLANTA MEDICA

Diterpene Lipo-Alkaloids with Selective Activities on Cardiac K+ Channels

(2017) Tivadar Kiss et al.   PLANTA MEDICA

Cytotoxicity of Aconitum alkaloid and its interaction with calf thymus DNA by multi-spectroscopic techniques

(2017) Fei Liu et al.   Scientific Reports

Aconitum carmichaelii Debeaux, cultivated as a medicinal plant in western China

(2016) Ma Yu et al.   GENETIC RESOURCES AND CROP EVOLUTION

Influence of total flavonoids derived fromChoerospondias axillaris foliumon aconitine-induced antiarrhythmic action and hemodynamics in Wistar rats

(2016) Min Qiu et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Case reports of aconite poisoning in mainland China from 2004 to 2015: A retrospective analysis

(2016) Haoran Li et al.   Journal of Forensic and Legal Medicine

Induction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug–drug interactions

(2016) Jinjun Wu et al.   Scientific Reports

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents

(2015) Koji Wada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux

(2015) Guohong Zhou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Clinical Aspects of Aconitum Preparations

(2015) Chi-Jung Tai et al.   PLANTA MEDICA

Aconitine-induced Ca2+ overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats

(2014) Gui-bo Sun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Aconitum Alkaloid Poisoning Related to the Culinary Uses of Aconite Roots

(2014) Thomas Chan   Toxins

Identification of diterpene alkaloids from Aconitum napellus subsp. firmum and GIRK channel activities of some Aconitum alkaloids

(2013) Tivadar Kiss et al.   FITOTERAPIA

In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16

(2013) Juan Du et al.   MOLECULES

The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?

(2013) S. Casey Laizure et al.   PHARMACOTHERAPY

Aconite poisoning following the percutaneous absorption of Aconitum alkaloids

(2012) Thomas Y.K. Chan   FORENSIC SCIENCE INTERNATIONAL

Diterpenoid Alkaloids from the Chinese Traditional Herbal “Fuzi” and Their Cytotoxic Activity

(2012) Feng Gao et al.   MOLECULES

Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine

(2011) Yan Fang Fan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evidence for aconitine-induced inhibition of delayed rectifier K+ current in Jurkat T-lymphocytes

(2011) Sheng-Nan Wu et al.   TOXICOLOGY

Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes

(2011) Lan Tang et al.   TOXICOLOGY LETTERS

Aconitine blocks HERG and Kv1.5 potassium channels

(2010) Yifu Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Study of neurotoxic effects and underlying mechanisms of aconitine on cerebral cortex neuron cells

(2009) Cheng Peng et al.   ARCHIVES OF PHARMACAL RESEARCH

Aconite poisoning

(2009) Thomas Y.K. Chan   CLINICAL TOXICOLOGY

Aconitum in Traditional Chinese Medicine—A valuable drug or an unpredictable risk?

(2009) Judith Singhuber et al.   JOURNAL OF ETHNOPHARMACOLOGY

Gut Microbiota and Its Possible Relationship With Obesity

(2009) John K. DiBaise et al.   MAYO CLINIC PROCEEDINGS