Article
Chemistry, Multidisciplinary
Shuaikai Ren, Chunxin Wang, Liang Guo, Congcong Xu, Yan Wang, Changjiao Sun, Haixin Cui, Xiang Zhao
Summary: Microcapsules with uniform size and tailored dimensions were prepared using emulsification and solvent evaporation methods in this study for the construction of controlled-release drug carriers. Morphology and structure of the microcapsules could be tailored by regulating the preparation conditions, and the release rate of protein could be controlled by adjusting the pore size. This controlled-release novel microcapsule carrier system shows great potential for biomedical applications.
Article
Chemistry, Applied
Ling Tang, Yi-Hong Chen, Qiong Wang, Xiao-Hui Wang, Qing-Xi Wu, Zhi-Feng Ding
Summary: The study focused on overcoming the challenges bioactive proteins face in the harsh gastric environment, utilizing microencapsulation as a strategy to protect them. Bovine serum albumin and ovalbumin were used as model proteins, with a polylysine-alginate complex fabricated for microencapsulation. Results showed that the protein-loaded microcapsules exhibited excellent tolerability to the acidic gastric environment, with slow release in simulated gastric fluids and sustained release in intestinal fluids. The developed microcapsules could potentially be used as a vehicle for bioactive proteins in functional foods, health care products, and medical formulations.
Article
Materials Science, Multidisciplinary
Qunna Xu, Jiaojiao Li, Yang Ding, Jianzhong Ma, Zhongxue Bai, Yuxi Yang
Summary: In this study, a zein-based hybrid microcapsule was successfully fabricated using zein, Pluronic F127, artemisia argyis essence, and butyl titanate. The hybrid microcapsule exhibited stable structure, sustained release behavior, and superior self-cleaning performance due to the presence of TiO2 in the outer shell. It has potential applications as a bio-based functional coating in various fields.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Food Science & Technology
Samaneh Tayebi-Moghaddam, Razieh Khatibi, Sevil Taklavi, Mona Hosseini-Isfahani, Hassan Rezaeinia
Summary: In this study, the sustained-release of clove essential oil (CEO) loaded into electrospun nanofibers of zein was used as a biopreservative to extend the shelf life of Iranian white cheese. Different loading levels of CEO affected the fiber structure and mechanical properties, while the gentle release of CEO effectively suppressed bacterial growth in the cheese.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Li, Chao Liu, Xiaoqian Gai, Chao Deng, Haiying Wei, Yuqian Liu, Huining Xiao
Summary: This study developed a paper-based mulch with good slow-release and photolysis resistance properties, which can almost completely biodegrade in soil. Therefore, this environmentally friendly mulch is a sustainable approach for pesticide usage and an excellent alternative to conventional agricultural plastic mulch.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Applied
Xueyan Hou, Haitao Zhao, Wenbo Zhang, Haojie Ma, Ran Li, Bo Han, Yuqi Zhang, Ji-Jiang Wang
Summary: A type of porous shell moisture-regulating microcapsules (MRM) was prepared by self-assembling chitosan and graphene oxide onto the surface of paraffin, followed by chemical precipitation of SiO2. The MRM was used to enhance the water vapor permeability of polyurethane composite coating, while maintaining the transparency and mechanical properties of the films. The composite coating exhibited improved comfort of leather by enhancing water vapor permeability with slight increase in water resistance.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Pharmacology & Pharmacy
Lian Shen, Xiaohong Yu, Hui Fu, Sainan Wei, Weiguang Shan, Yan Yang
Summary: Capsules were coated using two thermoforming coating techniques, VFC and CFC, with VFC process being more suitable for lower temperature. Drug release rate decreased with increasing film thickness, and the optimal coatings exhibited sustained-release properties.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Esther Marie JieRong Lin, Chee Leng Lay, Gomathy Sandhya Subramanian, Wui Siew Tan, Susanna Su Jan Leong, Lionel Chuan Hui Moh, Kaiyang Lim
Summary: The study developed an improved antimicrobial catheter coating with enhanced controlled-release functionality, demonstrating superior antimicrobial performance and sustainability compared to commercial antimicrobial catheters.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Paper & Wood
Yanan Wang, Hanyu Zhao, Lijie Huang, Guangxue Chen, Zhehao Wei, Qi Mo, Yishan Li, Xiyue Wang, Chongxing Huang, Qifeng Chen
Summary: In this study, a sustained-release gel for chlorine dioxide (ClO2) gas was developed using degradable materials such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and beta-cyclodextrin (beta CD) through a simple and benign crosslinking strategy. The gel showed sustained-release property within a wide temperature range and released ClO2 gas effectively for more than 30 days. A new diffusion model based on the Korsmeyer-Peppas model was proposed and achieved an excellent fit. This sustained-release gel provides guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained-release model of skeleton-soluble hydrogels.
Article
Chemistry, Medicinal
Yun-Hong Wang, Tong Qu, Xue-Lian Wang, Rong-Ping Yang
Summary: This study investigated the preparation of sustained-release microcapsules of salvianolic acid using chitosan as the carrier. The optimal conditions for the preparation process were identified, resulting in smooth-surfaced microcapsules with high drug loading and sustained release characteristics. The properties of salvianolic acid were maintained in the microcapsules, demonstrating the successful preparation of sustained-release microcapsules of salvianolic acid using marine polysaccharide as a carrier.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Nanoscience & Nanotechnology
Wenjing Jiang, Gang Zhou, Jinjie Duan, Dong Liu, Qingtao Zhang, Fuchao Tian
Summary: By using phacoemulsification-solvent volatilization, a multifunctional sustained-release microcapsule (SFRM) was successfully synthesized with superior particle size distribution and thermal stability. The study demonstrates that SFRM has satisfactory slow-release and flame-retardancy properties, with a repair rate reaching approximately 61%.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Chemical
Jiandong Zuo, Biqin Dong, Feng Xing, Chaoyun Luo, Jia Zhan, Lei Wang
Summary: Corrosion inhibitor microcapsules prepared by centrifugation-coating method showed excellent surface morphology, thermal stability, and mechanical properties, with thicker walls obtained at higher weight gain rates of wall material leading to slower release rates. Polymethyl methacrylate as wall material released drugs faster than ethyl cellulose in simulated concrete pore solution.
Article
Food Science & Technology
Ren Liu, Jian Wang, Chongxing Huang, Hongxia Su, Haohe Huang, Wanru Luo, Jiejie An, Hui Zhao, Yangfan Xu, Shuangfei Wang
Summary: In this study, sodium alginate-NaClO2 solution was encapsulated in ethylcellulose microcapsules and used to prepare an antimicrobial film. The film released ClO2 gas when exposed to water vapor, inhibiting the growth of bacteria and molds on strawberry surfaces.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Xiaoxing Yan, Wenwen Peng
Summary: The study found that increasing the mass fraction of microcapsules led to an increase in color difference, a decrease in glossiness, and an increase in hardness, while adhesion decreased, except for a mass fraction of 0.50:1. Impact resistance increased first and then decreased or remained constant as the mass fraction of microcapsules increased, and elongation at break increased first and then decreased. Coatings showed better liquid resistance when the core-shell ratio was small and the mass fraction was between 5.0% and 15.0%. The overall property of the coating on Basswood was best at a core-shell ratio of 0.67:1 and a mass fraction of 10.0%.
Article
Agriculture, Dairy & Animal Science
Zhenglie Dai, Xiuxi Wang, Yulan Liu, Jinsong Liu, Shiping Xiao, Caimei Yang, Yifan Zhong
Summary: This study aimed to investigate the effects of sodium butyrate (SB) and microcapsule sustained-release sodium butyrate (MSSB) on the health of yellow broilers. The results showed that dietary supplementation of both SB and MSSB improved growth performance and immune function in yellow broilers. Additionally, both supplements had an impact on the diversity, structure, and function of gut microbiota.
Article
Polymer Science
Kinga Grenda, Alexander Idstrom, Lars Evenas, Michael Persson, Krister Holmberg, Romain Bordes
Summary: Polyethyleneimine (PEI) is a common polymer used in various applications, with diverse structures such as linear and branched. Characterization methods including Fourier transform infrared spectroscopy, thermogravimetric analysis, and nuclear magnetic resonance spectroscopy have been utilized to gain insights into its structure and functional groups, with quantitative C-13 NMR analysis being particularly useful in determining the degree of branching.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Electrochemistry
Mazharul Haque, Iqbaal Abdurrokhman, Alexander Idstrom, Qi Li, Azega Rajaras, Anna Martinelli, Lars Evenas, Per Lundgren, Peter Enoksson
Summary: In this study, an ionic thermoelectric system based on the thermocapacitive effect is developed, which does not require a fixed temperature gradient. The system demonstrates high voltage output and the ability to convert low-grade thermal energy into stored electricity.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Applied
Chonnipa Palasingh, Koyuru Nakayama, Felix Abik, Kirsi S. Mikkonen, Lars Evenas, Anna Strom, Tiina Nypelo
Summary: This paper elucidates the procedure for the periodate oxidation of xylan into dialdehyde xylan and its further reduction into a dialcohol form and is focused on the modification work up. The oxidation-reduction reaction decreased the molecular weight of xylan while increased the dispersity more than 50%. Unlike the unmodified xylan, all the modified grades could be solubilized in water, which is essential for facilitating the future engineering applications of xylan.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Hanna Ulmefors, Ting Yang Nilsson, Viktor Eriksson, Gustav Eriksson, Lars Evenas, Markus Andersson Trojer
Summary: Continuous polysaccharide fibers and nonwovens based on cellulose, hydroxypropyl cellulose, chitosan, or alginate-containing biopolymeric microcapsules or mesoporous silica nanoparticles are prepared using wet-spinning or solution blowing technique. The microcapsules are distributed uniformly in the fiber matrices, while the nanoparticles form discrete micron-sized aggregates. By encapsulating a model compound, it is shown that a significant amount of the substance remains in the fiber during the formation process. The release behavior of the encapsulated compound is influenced by the material composition.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Chiara Magnani, Mina Fazilati, Roland Kadar, Alexander Idstrom, Lars Evenas, Jean -Marie Raquez, Giada Lo Re
Summary: In this study, chitin nanocrystals (ChNCs) were extracted using a waterborne topochemical one-pot acid hydrolysis/Fischer esterification method, and their surfaces were simultaneously decorated with lactate or butyrate moieties. The modified ChNC colloids showed a gel-like phase, disrupting the formation of liquid crystalline clusters. Pickering emulsions prepared from lyophilized nanocrystals demonstrated that the individualization of the modified ChNCs can be regenerated from the dry state.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Paper & Wood
Roujin Ghaffari, Henrik Almqvist, Alexander Idstrom, Ioanna Sapouna, Lars Evenas, Gunnar Liden, Martin Lawoko, Anette Larsson
Summary: The transport of lignin fragments from cells and fibers to black liquor is crucial in the delignification process, but our understanding of its diffusion through cellulose is limited. Therefore, a comprehensive study on lignin mass transport through cellulosic materials is important.
Article
Chemistry, Physical
Smaragda-Maria Argyri, Lars Evenas, Romain Bordes
Summary: Acoustic levitation can deform droplets and measure their surface tension based on their deviation from sphericity. However, there is currently no model that relates the acoustic pressure field to deformation and surface tension. Using a machine learning algorithm can identify correlations between experimental data without any preconditions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Ziyauddin Khan, Anna Martinelli, Leandro R. Franco, Divyaratan Kumar, Alexander Idstrom, Lars Evenas, C. Moyses Araujo, Xavier Crispin
Summary: Water-in-polymer salt electrolytes (WiPSEs) based on potassium polyacrylate (PAAK) are a new type of water-in-salt electrolytes that could potentially be a solution for large-scale supercapacitors to stabilize the electric grid in short time frames. WiPSEs have broad electrochemical stability up to 3V, are nonflammable, and have high ionic conductivity (100 mS/cm), which is desirable for high-power devices. However, the matter transport in PAAK-based WiPSEs has not been studied.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Applied
Dongming Zhang, Reskandi C. Rudjito, Solja Pietiainen, Shu-Chieh Chang, Alexander Idstrom, Lars Evenas, Francisco Vilaplana, Amparo Jimenez-Quero
Summary: The intake of dietary fibers is important for human health. Two types of arabinoxylan fibers, one with ferulic acid linked and one without, were produced from wheat bran. The fibers were used in bread production and their interaction with other macromolecules in the bread was investigated. The non-digestability of the fibers was confirmed and they showed potential prebiotic effects during fermentation with probiotic bacteria.
Article
Biochemistry & Molecular Biology
Eduardo Maurina Morais, Alexander Idstrom, Lars Evenaes, Anna Martinelli
Summary: The dynamical properties of four protic ionic liquids containing ethyltriazolium and ethylimidazolium cations were investigated with triflate and bistriflimide anions. The transport properties were strongly influenced by the cation nature, with the ethyltriazolium cation resulting in slower dynamics. The fragility of the ionic liquids was estimated to fall within the range of very fragile glass-forming materials.
Article
Chemistry, Physical
Anne-Laure Fameau, Romain Bordes, Lars Evenaes, Cosima Stubenrauch
Summary: Bioassays are widely used in healthcare to detect and quantify biomarkers, such as molecules or enzymes, which are crucial in monitoring diseases and health conditions. In developed countries, healthcare professionals use specialized reagents and equipment to perform these bioassays. However, in less-industrialized countries, the creation of low cost, fast, and technically simple bioassays is required.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Biomaterials
Viktor Eriksson, Jules Mistral, Ting Yang Nilsson, Markus Andersson Trojer, Lars Evenas
Summary: Functional textiles is a rapidly growing product segment where sustained release of actives is crucial. This study introduces microcapsules as a method to extend the release of active substances in textiles, compared to conventional impregnation methods. Encapsulated pyrene shows a significantly lower diffusion coefficient compared to impregnated pyrene, demonstrating the barrier properties of microcapsules that can prolong the potential functionality from hours to weeks.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Viktor Eriksson, Leyla Beckerman, Erik Aerts, Markus Andersson Trojer, Lars Evenaes
Summary: This study developed stimulus-responsive microcapsules for controlled release of the entire load by external stimuli. The core-shell microcapsules exhibited pH-controlled triggered release with a remarkably narrow triggering pH interval. The degradation kinetics of the shell correlated excellently with diffusion coefficients fitted to release measurements at varying pH values.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)