Article
Biochemistry & Molecular Biology
Li Zhang, Li Ma, Yaping Pan, Xinxin Zheng, Qi Sun, Zichao Wang, Qi Wang, Hanzhen Qiao
Summary: The study found that low molecular weight polysaccharides have higher inhibitory effects against Escherichia coli and Staphylococcus aureus compared to high molecular weight polysaccharides, with stronger activity against the latter. Additionally, the minimum inhibitory concentrations of low molecular weight polysaccharides were lower than those of high molecular weight polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Yu-Heng Mao, Yixuan Xu, Fenglin Song, Zhao-Mei Wang, Yan-Heng Li, Mingzhu Zhao, Fang He, Zezhong Tian, Yan Yang
Summary: This study demonstrates the protective effects of high molecular weight konjac glucomannan (KGM) on the gut microbiome against antibiotic perturbation, as well as its ability to increase the production of short-chain fatty acids in the gut.
CARBOHYDRATE POLYMERS
(2022)
Article
Agriculture, Multidisciplinary
Jiaxiong Wu, Chengxiao Yu, Sihuan Shen, Yanming Ren, Huan Cheng, Hang Xiao, Donghong Liu, Shiguo Chen, Xingqian Ye, Jianle Chen
Summary: Fermentation characteristics and structural properties of high rhamnogalacturonan I pectic polysaccharides (RGI) and free-radical degraded RGI (DRGI) were studied using a human fecal batch-fermentation model. The results showed that RGI degraded faster and produced more acetate and propionate than DRGI. Both RGI and DRGI promoted the growth of Bacteroides, Bifidobacterium, and Lactobacillus, but the composition and metabolic pathways of the microbiota differed between them. This study emphasized the importance of large molecular weight in the gut microbiota modulatory effect of RGI-type pectic polysaccharides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Lilong Wang, Linlin Wang, Chunhong Yan, Chunqing Ai, Chengrong Wen, Xiaoming Guo, Shuang Song
Summary: This study aimed to elucidate the structure and anti-inflammatory mechanisms of fucoidans found in Ascophyllum nodosum. Two novel fucoidans, ANP-6 and ANP-7, were isolated and their structures were elucidated. The results showed that ANP-6 and ANP-7 could inhibit inflammation by regulating inflammatory signaling pathways, and the molecular weight of fucoidans played a role in their anti-inflammatory effects.
Article
Multidisciplinary Sciences
Shima Keisandokht, Valerie Orsat, Salwa Karboune, Bhalamurugan Gatamaneni Loganathan
Summary: Microwave-assisted extractions (MAE) of hydrocolloids from basil seed, fenugreek seed, and psyllium seed husk showed higher extraction yields and less destructive effects on functional properties compared to conventional heating extraction (CHE). The extracted hydrocolloids exhibited similar dielectric properties and shear-thinning behavior, with psyllium seed husk showing the highest viscosity. Dynamic flow measurements indicated weak gel characteristics for basil seed husk and psyllium seed husk hydrocolloids.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Yifan Chen, Weixuan Huang, Yang Chen, Minqian Wu, Ruohan Jia, Lijun You
Summary: By degrading LJP with UV/H2O2, hydrogels with different molecular weights were produced for wound dressings with excellent anti-inflammatory activity and swelling property. Low Mw LJP-based hydrogels showed great potential for wound dressing application.
Article
Chemistry, Applied
Laura Roman, Benjamin Baylis, Karl Klinger, Jondavid de Jong, John R. Dutcher, Mario M. Martinez
Summary: This study investigates the structure of maize phytoglycogen nanoparticles and the impact of shear scission on their properties. The results reveal changes in the radius, mass density, and stiffness of the nanoparticles after shear scission.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Martin Gericke, Lennart Hendrik Skodda, Thomas Heinze, Friedrich Schiller
Summary: A modular synthesis approach was used to obtain reactive xylan derivatives for further functionalization and chemical crosslinking. The synthesized compounds were characterized and their potential applications in preparing xylan-based hydrogels were demonstrated.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Canbiao Zeng, Guangying Ye, Guochao Li, He Cao, Zaihua Wang, Shengguo Ji
Summary: This study compared the quantification analysis of dextran and glucose in the phenol sulfuric acid method and investigated the quantitative factors of water-soluble polysaccharides in the RID measurement. The results showed that RID measurement is a more reliable and satisfactory method, which can alleviate the drawbacks of the phenol-sulfuric acid method.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Jie Liu, Liru Zhang, Chang Liu, Xuejing Zheng, Keyong Tang
Summary: Crosslinking gelatin edible films with oxidized polysaccharides, such as pullulan dialdehyde (PDA), can significantly alter the structure and properties of the films. The molecular weight of PDA plays a crucial role in affecting the network structure and properties of the gelatin films. Overall, PDA crosslinking is a potential alternative for tuning the structure and properties of gelatin edible films.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guoyan Liu, Xue Yang, Jixian Zhang, Li Liang, Feng Miao, Tao Ji, Zhiqiang Ye, Meng Chu, Jiaoyan Ren, Xin Xu
Summary: The study demonstrated that Lycium barbarum polysaccharides (LBP), specifically LBP1, can be used as stabilizers and capping agents for uniformly dispersed selenium nanoparticles (SeNPs) with excellent stability. LBP1-decorated SeNPs showed smaller particle size and enhanced fatigue-relieving activity, as indicated by prolonged swimming time and improved biochemical markers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Food Science & Technology
Inas Suci Rahmawati, Harsi Dewantari Kusumaningrum, Nancy Dewi Yuliana, Azis Boing Sitanggang
Summary: A meta-analysis was conducted to investigate the relationship between depolymerised polysaccharides and their antibacterial activity. The study found that regardless of the type of polysaccharides, depolymerised polysaccharides showed better inhibitory activity against Escherichia coli compared to Staphylococcus aureus. Additionally, low molecular weight (<10 kDa) anionic and non-ionic polysaccharides were more effective than chitosan (10-100 kDa).
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Nutrition & Dietetics
Guo Liu, Jun Zhang, Qixin Kan, Mingyue Song, Tao Hou, Siyu An, Hongyu Lin, Hongzhang Chen, Liuyun Hu, Jie Xiao, Yunjiao Chen, Yong Cao
Summary: Ganoderma lucidum polysaccharides (GLP) have excellent immunomodulatory activity. Among them, the high molecular weight Restriction Fragment Length Polymorphism (RGLP) exhibits stronger immunomodulatory activity than the low molecular weight EGLP. Structural analysis reveals that RGLP-1 is a β-pyran polysaccharide with specific glycosyl bonds, showing potential immunomodulatory properties.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Shengchang Tao, Zhiyao Ren, Zerui Yang, Shuna Duan, Zhongxian Wan, Jiahui Huang, Chenxing Liu, Gang Wei
Summary: Our study demonstrated that the fraction of Dendrobium officinale polysaccharides with a molecular weight of 389.98 kDa exhibited the strongest antitumor effect against colorectal cancer; the specific fraction DOPW-1 could potentially be developed as a clinical agent for treating CRC; and DOPW-1 inhibits the proliferation of HT-29 cells by regulating the apoptosis pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Mina Zare, Kirsi S. Mikkonen
Summary: Phase change materials (PCMs) are thermo-responsive materials that can store thermal energy through phase transition. They have various applications in heat control and are increasingly used in life science fields. Paraffin wax and polyethylene glycol are the most commonly studied PCMs due to their low toxicity, high thermal stability, and ease of modification.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Food Science & Technology
Abedalghani Halahlah, Vieno Piironen, Kirsi S. Mikkonen, Thao M. Ho
Summary: The use of wood hemicelluloses (GGM and GX) in spray-dried microencapsulation and the effects of homogenization techniques on the physicochemical properties of feed solutions were investigated. The results showed that GGM and GX have high potential as wall materials in the spray-dried microencapsulation of bioactive compounds.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Food Science & Technology
Thao M. Ho, Mari Lehtonen, Heikki Raikkonen, Petri O. Kilpelainen, Kirsi S. Mikkonen
Summary: The study found that wood hemicelluloses obtained from by-products of forest industries are attractive alternatives as wall materials for spray-dried microencapsulation of bioactive compounds. These hemicelluloses have good emulsifying properties, low viscosity at high concentrations, high heat stability, and low heat transfer. Compared to gum Arabic, they have higher encapsulation efficiency and better protection against oil oxidation.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Agriculture, Multidisciplinary
Felix Abik, Chonnipa Palasingh, Mamata Bhattarai, Shaun Leivers, Anna Strom, Bjorge Westereng, Kirsi S. Mikkonen, Tiina Nypelo
Summary: Holistic utilization of all wood biomass is crucial for efficient forest resource use. Wood hemicelluloses, structurally similar to those from crops, have potential as food ingredients, but their applications are limited. This review explores the extraction processes, properties, and potential gastrointestinal effects of wood hemicelluloses, as well as the regulatory approval process and current applications in the food industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Engineering, Chemical
Abedalghani Halahlah, Heikki Raikkonen, Vieno Piironen, Fabio Valoppi, Kirsi S. Mikkonen, Thao M. Ho
Summary: This study investigated the applicability of wood hemicelluloses, including galactoglucomannans and glucuronoxylans, and their mixtures with carboxymethylcellulose as wall materials for microencapsulation of bilberry juice. The results showed that wood hemicelluloses have a high anthocyanin encapsulation efficiency, comparable to gum arabic. The microencapsulated powders prepared with wood hemicelluloses also exhibited higher phenolic content and antioxidant activities.
Article
Chemistry, Physical
Ziyauddin Khan, Anna Martinelli, Leandro R. Franco, Divyaratan Kumar, Alexander Idstrom, Lars Evenas, C. Moyses Araujo, Xavier Crispin
Summary: Water-in-polymer salt electrolytes (WiPSEs) based on potassium polyacrylate (PAAK) are a new type of water-in-salt electrolytes that could potentially be a solution for large-scale supercapacitors to stabilize the electric grid in short time frames. WiPSEs have broad electrochemical stability up to 3V, are nonflammable, and have high ionic conductivity (100 mS/cm), which is desirable for high-power devices. However, the matter transport in PAAK-based WiPSEs has not been studied.
CHEMISTRY OF MATERIALS
(2023)
Article
Agricultural Engineering
Abedalghani Halahlah, Felix Abik, Maarit H. Lahtinen, Asmo Kemppinen, Kalle Kaipanen, Petri O. Kilpelainen, Daniel Granato, Thao M. Ho, Kirsi S. Mikkonen
Summary: Softwood galactoglucomannan (GGM) can be recovered through pressurized hot water extraction, membrane filtration, and spray drying, yielding biopolymers suitable for renewable products. The pH and temperature of GGM liquor affect the properties of recovered GGM, and ultrafiltration at pH 10 and 60 degrees C resulted in GGM with unique gel formation capacity suitable for thickening agents or 3D printing.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemical Research Methods
Tomoko Kuribayashi, Pauliina Lankinen, Kirsi S. Mikkonen
Summary: We developed a simple solid-state culture system to efficiently screen fungal strains for mycelium-based materials production. The growth and density of mycelial mat were evaluated by weighing, and the relationship between substrate degradation and contact time with hyphae was investigated using a paper substrate. Ten fungal strains were assessed, and it was found that Pleurotus floridanus FBCC375 had a dense and elastic mycelial mat with mild substrate degradation, while Hypsizygus ulmarius FBCC573 and Trametes versicolor FBCC564 showed positional imbalance in decay activity within the colony. This simple method facilitates the screening of fungal strains and further development of mycelium-based materials.
JOURNAL OF MICROBIOLOGICAL METHODS
(2023)
Article
Food Science & Technology
Maarit H. Lahtinen, Emma Kynkaanniemi, Ching Jian, Anne Salonen, Anne-Maria Pajari, Kirsi S. Mikkonen
Summary: Recent studies suggest that lignin metabolism with unknown metabolic fates is occurring in the gastrointestinal tract of several animal models. This study focuses on analyzing the potential metabolites of lignin. The results show that lignin undergoes chemical structure alteration in the gastrointestinal tract and small fragmented lignin metabolites enter the plasma and are further processed in the liver. Additionally, the composition of gut microbiota is associated with lignin metabolism.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Patricia Figueiredo, Danila Morais de Carvalho, Maarit H. Lahtinen, Kristiina S. Hilden, Kirsi S. Mikkonen
Summary: The functionalization of lignin nanoparticles (LNPs) can be achieved through laccase-induced oxidation and polymerization, which can increase their application in various sectors. This study investigated the oxidation mechanism and its effect on the surface chemistry and polymerization of LNPs with different monomeric compositions. It was found that in-house produced laccases induce the formation of dimeric products and consequent polymerization and crosslinking of LNPs with low S/G ratio, while LNPs with high S/G ratio show a preferred C & alpha;-OH type of oxidation. These findings provide valuable insights for the development of tailored LNPs in biomedical and food sciences.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
Article
Chemistry, Physical
Anne-Laure Fameau, Romain Bordes, Lars Evenaes, Cosima Stubenrauch
Summary: Bioassays are widely used in healthcare to detect and quantify biomarkers, such as molecules or enzymes, which are crucial in monitoring diseases and health conditions. In developed countries, healthcare professionals use specialized reagents and equipment to perform these bioassays. However, in less-industrialized countries, the creation of low cost, fast, and technically simple bioassays is required.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Biomaterials
Viktor Eriksson, Jules Mistral, Ting Yang Nilsson, Markus Andersson Trojer, Lars Evenas
Summary: Functional textiles is a rapidly growing product segment where sustained release of actives is crucial. This study introduces microcapsules as a method to extend the release of active substances in textiles, compared to conventional impregnation methods. Encapsulated pyrene shows a significantly lower diffusion coefficient compared to impregnated pyrene, demonstrating the barrier properties of microcapsules that can prolong the potential functionality from hours to weeks.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Viktor Eriksson, Leyla Beckerman, Erik Aerts, Markus Andersson Trojer, Lars Evenaes
Summary: This study developed stimulus-responsive microcapsules for controlled release of the entire load by external stimuli. The core-shell microcapsules exhibited pH-controlled triggered release with a remarkably narrow triggering pH interval. The degradation kinetics of the shell correlated excellently with diffusion coefficients fitted to release measurements at varying pH values.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)