Journal
JOURNAL OF BIOCHEMISTRY
Volume 172, Issue 4, Pages 197-203Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvac055
Keywords
uncoupling protein 1; thermogenic adipocytes; calcium cycling thermogenesis; brown adipocyte; beige adipocyte
Categories
Funding
- Japan Diabetes Foundation
- Kanae Foundation for the Promotion of Medical Science
- Naito Foundation
- Ono Medical Research Foundation
- Novartis Foundation for the Promotion of Science
- Uehara Memorial Foundation
- MSD Life Science Foundation
- Astellas Foundation for Research on Metabolic Disorders
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Ichiro Kanehara Foundation for the Promotion of Medical Sciences
- AMED [JP21gm6210011]
- JSPS KAKENHI [21H02977]
- JST [Moonshot RD] [JPMJMS2023]
- Medical Care and Inamori Research
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Brown and beige adipocytes produce heat through non-shivering thermogenesis, primarily via UCP1 but also through UCP1-independent mechanisms, which play important roles in systemic energy and glucose homeostasis regulation.
Brown and beige adipocytes produce heat and control systemic energy via non-shivering thermogenesis. Historically, thermogenesis in brown and beige adipocytes was thought to be exclusively through a mitochondria-localized protein, uncoupling protein 1 (UCP1). However, recent studies identified UCP1-independent thermogenic mechanisms in adipocytes. Importantly, UCP1-independent pathways significantly contribute to systemic energy and glucose homeostasis. The finding of UCP1-independent mechanisms provided new opportunities to target the pathways in vivo. In this review, we discuss the current understandings of thermogenic mechanisms in adipocytes with a focus on Ca2+ futile cycling.
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