SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT

Model based on five tumour immune microenvironment-related genes for predicting hepatocellular carcinoma immunotherapy outcomes

(2021) Xinyu Gu et al.   Journal of Translational Medicine

Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation

(2021) Yan Liao et al.   Cancer Cell International

The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy

(2021) Jian Chen et al.   ONCOGENE

SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer

(2021) Meihua Jin et al.   Endocrine Connections

Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells

(2021) Ana Carolina B. Sant’Anna-Silva et al.   Cancers

Serine hydroxymethyltransferase 2: a novel target for human cancer therapy

(2021) Min Xie et al.   INVESTIGATIONAL NEW DRUGS

A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer

(2020) Manabu Kodama et al.   Nature Communications

Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2

(2020) Bing Liu et al.   OncoTargets and Therapy

N 6 ‐methyladenosine (m 6 A) RNA modification in human cancer

(2020) Fu‐Chun Huo et al.   CELL PROLIFERATION

Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer

(2019) Changwei Lin et al.   Cell Death & Disease

SHMT2 Promotes Liver Regeneration Through Glycine-activated Akt/mTOR Pathway

(2019) Menghao Wang et al.   TRANSPLANTATION

Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy

(2019) Aamod S. Dekhne et al.   MOLECULAR CANCER THERAPEUTICS

Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells

(2019) Lijuan Ji et al.   MEDICAL SCIENCE MONITOR

Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism

(2019) Marrocco et al.   Cells

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism

(2019) Aamod S. Dekhne et al.   MOLECULAR PHARMACOLOGY

Epigenetic regulation of m6A modifications in human cancer

(2019) Wei Zhao et al.   Molecular Therapy-Nucleic Acids

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

PAK5 promotes the migration and invasion of cervical cancer cells by phosphorylating SATB1

(2018) Fu-Chun Huo et al.   CELL DEATH AND DIFFERENTIATION

Insilico structure modeling and molecular docking analysis of phosphoribosyl pyrophosphate amidotransferase (PPAT) with antifolate inhibitors

(2018) Nousheen Bibi et al.   CURRENT CANCER DRUG TARGETS

Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas

(2017) Ming Wu et al.   OncoTargets and Therapy

Renal cell carcinoma

(2017) James J. Hsieh et al.   Nature Reviews Disease Primers

Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma

(2016) Chern Chiuh Woo et al.   Oncotarget

Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression

(2015) Zhaoyong Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer

(2015) Moloy T. Goswami et al.   Oncotarget

Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer

(2014) John T. Cunningham et al.   CELL

Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease

(2014) Milojkovic Boban et al.   RENAL FAILURE

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

(2014) A Paone et al.   Cell Death & Disease

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(2014) J. Ye et al.   Cancer Discovery

Fuzzy optimization for detecting enzyme targets of human uric acid metabolism

(2013) Kai-Cheng Hsu et al.   BIOINFORMATICS

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Shmt1 Heterozygosity Impairs Folate-Dependent Thymidylate Synthesis Capacity and Modifies Risk of Apcmin-Mediated Intestinal Cancer Risk

(2011) A. J. MacFarlane et al.   CANCER RESEARCH

Metabolic Flux and the Regulation of Mammalian Cell Growth

(2011) Jason W. Locasale et al.   Cell Metabolism