Peroxisome proliferator-activated receptor-γ ameliorates neuronal ferroptosis after traumatic brain injury in mice by inhibiting cyclooxygenase-2

Novel measures of Morris water maze performance that use vector field maps to assess accuracy, uncertainty, and intention of navigational searches

(2022) Prabod Kumar Meenakshi et al.   HIPPOCAMPUS

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

(2021) Wen-Dai Bao et al.   CELL DEATH AND DIFFERENTIATION

Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury

(2021) Haijian Wu et al.   Journal of Neuroinflammation

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

Pharmacological blockers of CCR5 and CXCR4 improve recovery after traumatic brain injury

(2021) Yael Friedman-Levi et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective and antioxidative effects of pioglitazone in brain tissue adjacent to the ischemic core are mediated by PI3K/Akt and Nrf2/ARE pathways

(2021) Yi Zhao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury

(2021) Zhongyuan Bao et al.   Nature Communications

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

“Iron free” zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis

(2020) Changping Zhang et al.   Cell Death & Disease

Therapeutic Potential of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists in Substance Use Disorders: A Synthesis of Preclinical and Human Evidence

(2020) Justin Matheson et al.   Cells

Role of Peroxisome Proliferated Activated Receptor gamma (PPARγ) in Different Disease States: Recent Updates

(2020) Suvadeep Mal et al.   CURRENT MEDICINAL CHEMISTRY

Protective effects of chondroitin sulphate nano-selenium on a mouse model of Alzheimer's disease

(2020) Dongsheng Ji et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia‐reperfusion

(2020) Yixin Xu et al.   FASEB JOURNAL

FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson’s Disease

(2020) Ye Tian et al.   Neurotherapeutics

The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury

(2020) Sicheng Tang et al.   Frontiers in Cellular Neuroscience

Two Rationally Identified Novel Glitazones Reversed the Behavioral Dysfunctions and Exhibited Neuroprotection Through Ameliorating Brain Cytokines and Oxy-Radicals in ICV-LPS Neuroinflammatory Rat Model

(2020) Antony Justin et al.   Frontiers in Neuroscience

Ferrostatin-1 alleviates angiotensin II (Ang II)- induced inflammation and ferroptosis in astrocytes

(2020) Sijia Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy

(2020) Hongtao Chen et al.   Redox Biology

Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy

(2019) Jiang Fang et al.   Frontiers in Neuroscience

Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity

(2019) Tommaso Nuzzo et al.   EXPERIMENTAL NEUROLOGY

The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury

(2019) Qingxiu Zhang et al.   PLOS BIOLOGY

PPARA, PPARD and PPARG gene polymorphisms in patients with unstable angina

(2019) Agnieszka Maciejewska-Skrendo et al.   GENE

Recent advances in traumatic brain injury

(2019) Abdelhakim Khellaf et al.   JOURNAL OF NEUROLOGY

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Neuroprotective effects of irisin against cerebral ischemia/ reperfusion injury via Notch signaling pathway

(2019) Zhao Jin et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

(2018) Marc P. Baggelaar et al.   PROGRESS IN LIPID RESEARCH

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

(2018) Wei Cai et al.   PROGRESS IN NEUROBIOLOGY

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

(2018) Eran Agmon et al.   Scientific Reports

Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage

(2018) Zhuwei Zhang et al.   BRAIN RESEARCH

Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice

(2018) Bao-Shu Xie et al.   CNS Neuroscience & Therapeutics

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

(2018) Elizabeth M. Kenny et al.   CRITICAL CARE MEDICINE

The role of various peroxisome proliferator-activated receptors and their ligands in clinical practice

(2017) Giuseppe Derosa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Severe traumatic brain injury: targeted management in the intensive care unit

(2017) Nino Stocchetti et al.   LANCET NEUROLOGY

Neuronal loss, demyelination and volume change in the multiple sclerosis neocortex

(2017) D. Carassiti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rosiglitazone attenuates inflammation and CA3 neuronal loss following traumatic brain injury in rats

(2016) Hao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapies targeting lipid peroxidation in traumatic brain injury

(2016) Tamil Selvan Anthonymuthu et al.   BRAIN RESEARCH

Update on stereology for light microscopy

(2015) Stefano Geuna et al.   CELL AND TISSUE RESEARCH

PPAR-γ Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-κB-Driven p22phox Transcription

(2015) Jui-Sheng Wu et al.   MOLECULAR NEUROBIOLOGY

Review of the Structural and Dynamic Mechanisms of PPARγPartial Agonism

(2015) Alice J. Kroker et al.   PPAR Research

Phosphatidylserine in the brain: Metabolism and function

(2014) Hee-Yong Kim et al.   PROGRESS IN LIPID RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The Functional Interaction between Acyl-CoA Synthetase 4, 5-Lipooxygenase and Cyclooxygenase-2 Controls Tumor Growth: A Novel Therapeutic Target

(2012) Ulises D. Orlando et al.   PLoS One

Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ

(2011) Huizhi Du et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mouse closed head injury model induced by a weight-drop device

(2009) Michael A Flierl et al.   Nature Protocols

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE