Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists

Peptide-based long-acting co-agonists of GLP-1 and cholecystokinin 1 receptors as novel anti-diabesity agents

(2022) Qimeng Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Established and emerging roles peptide YY (PYY) and exploitation in obesity–diabetes

(2021) Ryan A. Lafferty et al.   Current Opinion in Endocrinology Diabetes and Obesity

Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice

(2021) Ryan A. Lafferty et al.   Frontiers in Endocrinology

Metabolic responses and benefits of glucagon‐like peptide‐1 (GLP‐1) receptor ligands

(2021) Neil Tanday et al.   BRITISH JOURNAL OF PHARMACOLOGY

Circadian Regulation of the Pancreatic Beta Cell

(2021) Nivedita Seshadri et al.   ENDOCRINOLOGY

Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

(2021) Chenxu Yan et al.   Nature Communications

Amplifying the antidiabetic actions of glucagon‐like peptide‐1: Potential benefits of new adjunct therapies

(2021) Neil Tanday et al.   DIABETIC MEDICINE

Classical and non-classical islet peptides in the control of β-cell function

(2021) Dawood Khan et al.   PEPTIDES

Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction

(2020) Ryan A. Lafferty et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Liraglutide and sitagliptin counter beta- to alpha-cell transdifferentiation in diabetes

(2020) Neil Tanday et al.   JOURNAL OF ENDOCRINOLOGY

The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin

(2020) Sarah L. Craig et al.   BIOCHEMICAL PHARMACOLOGY

Chronopharmacology of dapagliflozin-induced antihyperglycemic effects in C57BL/6J mice

(2019) Hiroki Yoshioka et al.   Obesity Research & Clinical Practice

Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice

(2019) Dipak Sarnobat et al.   PEPTIDES

GIP analogues augment bone strength by modulating bone composition in diet-induced obesity in mice

(2019) Sagar S. Vyavahare et al.   PEPTIDES

A GIP/xenin hybrid in combination with exendin-4 improves metabolic status in db/db diabetic mice and promotes enduring antidiabetic benefits in high fat fed mice

(2019) S.L. Craig et al.   BIOCHEMICAL PHARMACOLOGY

Peptide YY (1–36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β‐cell function, growth and survival

(2019) Ryan A. Lafferty et al.   DIABETES OBESITY & METABOLISM

C-terminal degradation of PYY peptides in plasma abolishes effects on satiety and beta-cell function

(2018) R.A. Lafferty et al.   BIOCHEMICAL PHARMACOLOGY

The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response

(2017) Jingqi Fu et al.   FOOD AND CHEMICAL TOXICOLOGY

Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: A systematic analysis of published clinical trials

(2016) Karolin Bettge et al.   DIABETES OBESITY & METABOLISM

Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival

(2016) Dawood Khan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

An Update on the Effect of Incretin-Based Therapies on β-Cell Function and Mass

(2016) Suk Chon et al.   Diabetes & Metabolism Journal

Functional GIP receptors play a major role in islet compensatory response to high fat feeding in mice

(2015) R. Charlotte Moffett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Sequential induction of beta cell rest and stimulation using stable GIP inhibitor and GLP-1 mimetic peptides improves metabolic control in C57BL/KsJ db/db mice

(2015) Varun Pathak et al.   DIABETOLOGIA

Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls

(2013) D. J. Drucker   DIABETES

Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

(2011) Emilie Faivre et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Liraglutide: the therapeutic promise from animal models

(2010) L. B. Knudsen   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents

(2009) Masayuki Arakawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thiazolidinediones in prediabetes and early type 2 diabetes: What can be learned about that disease’s pathogenesis

(2009) Jack L. Leahy   Current Diabetes Reports

Beneficial Effects of Insulin on Glycemic Control and  -Cell Function in Newly Diagnosed Type 2 Diabetes With Severe Hyperglycemia After Short-Term Intensive Insulin Therapy

(2008) H.-S. Chen et al.   DIABETES CARE

Effects of beta-cell rest on beta-cell function: a review of clinical and preclinical data

(2008) Rebecca J Brown et al.   PEDIATRIC DIABETES