Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

(2022) Laura Vangeel et al.   ANTIVIRAL RESEARCH

Disposition of PF-07321332 (Nirmatrelvir), an Orally Bioavailable Inhibitor of SARS-CoV-2 3CL Protease, across Animals and Humans

(2022) Heather Eng et al.   DRUG METABOLISM AND DISPOSITION

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19

(2022) Jennifer Hammond et al.   NEW ENGLAND JOURNAL OF MEDICINE

Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID‐19 Trial of Nirmatrelvir

(2022) Ravi Shankar P. Singh et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Quantitative NMR as a Versatile Tool for the Reference Material Preparation

(2021) Kihwan Choi et al.   Magnetochemistry

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

(2021) Dafydd R. Owen et al.   SCIENCE

An ex vivo fermentation screening platform to study drug metabolism by human gut microbiota

(2018) Evita van de Steeg et al.   DRUG METABOLISM AND DISPOSITION

19F-NMR based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers

(2018) David Pearson et al.   XENOBIOTICA

Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine (19F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies

(2012) Abdul Mutlib et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Human radiolabeled mass balance studies: objectives, utilities and limitations

(2009) Natalia Penner et al.   BIOPHARMACEUTICS & DRUG DISPOSITION