Article
Biochemistry & Molecular Biology
Alice Marino, Derek J. Hausenloy, Ioanna Andreadou, Sandrine Horman, Luc Bertrand, Christophe Beauloye
Summary: Heart failure is a major cause of death and disability globally, with left ventricular remodeling, fibrosis, and ischemia/reperfusion injury contributing to cardiac dysfunction. AMPK acts as a universal energy sensor in response to low ATP levels, playing a crucial role in the heart. Excessive reactive oxygen species can activate AMPK, providing an additional role as a redox sensor for preventing heart failure progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Ioanna Andreadou, Panagiotis Efentakis, Katie Frenis, Andreas Daiber, Rainer Schulz
Summary: Thiol-based redox compounds, including thioredoxins, glutaredoxins, and peroxiredoxins, play crucial roles in antioxidant processes and redox signaling in the cardiovascular system. They regulate redox signaling events through reversible thiol modifications and contribute indirectly to reactive oxygen species detoxification.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Review
Chemistry, Medicinal
Huiting Xia, Aqeela Zahra, Meng Jia, Qun Wang, Yunfu Wang, Susan L. Campbell, Jianping Wu
Summary: In this review, the potential role of NHE1 in cardiac hypertrophy and heart failure is discussed, along with an investigation into the underlying molecular mechanisms.
Article
Medicine, Research & Experimental
Suman Dalal, Paige L. Shook, Mahipal Singh, Krishna Singh
Summary: This study investigates the cardioprotective effect of exogenous ubiquitin (UB) treatment in a mouse model of myocardial ischemia/reperfusion (I/R) injury. The results show that UB treatment improves heart function and reduces myocardial fibrosis, apoptosis, hypertrophy, and serum cytokine/chemokine levels.
Review
Endocrinology & Metabolism
Qingwen Yu, Guangyuan Zhao, Jingjing Liu, Yajie Peng, Xueli Xu, Fei Zhao, Yangyang Shi, Chengyun Jin, Ji Zhang, Bo Wei
Summary: Heart diseases are a major cause of morbidity and mortality worldwide, with complex underlying mechanisms. Disordered cardiac metabolism, including the role of histone deacetylases (HDACs), plays a key role in various heart diseases. Understanding the regulation of HDACs in cardiac energy metabolism could lead to the development of new therapeutic strategies for heart diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Review
Medicine, Research & Experimental
Xiaoguang Wu, Yi Li, Shuchen Zhang, Xiang Zhou
Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.
Review
Biochemistry & Molecular Biology
Rainer Schulz, Klaus-Dieter Schlueter
Summary: Reactive oxygen species (ROS) play dual roles in disease development and cell signaling pathways. Cardiomyocytes generate the largest amount of ROS through mitochondria. Uncoupling protein (UCP) and monoamine oxidases (MAO) have been identified as modifiers of mitochondrial ROS formation. This review highlights the role of UCP and MAO in cardiac injuries induced by ischemia-reperfusion (I/R) and their potential for protection from I/R and heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Shuxian Chen, Yuanming Zou, Chunyu Song, Kexin Cao, Kexin Cai, Yanjiao Wu, Zhaobo Zhang, Danxi Geng, Wei Sun, Nanxiang Ouyang, Naijin Zhang, Zhao Li, Guozhe Sun, Yixiao Zhang, Yingxian Sun, Ying Zhang
Summary: Cardiovascular disease is a significant threat to human health, and the glycolytic pathway and its enzymes play important roles in its development.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Review
Medicine, Research & Experimental
Yong -Ping Liu, Ri Wen, Chun-Feng Liu, Tie-Ning Zhang, Ni Yang
Summary: Sirtuins (SIRTs) are nicotinic adenine dinucleotide (+)-dependent histone deacetylases that play critical roles in regulating signaling pathways in prokaryotes and eukaryotes. Recent studies have demonstrated the involvement of SIRTs in key pathways for cell function in cardiovascular processes such as cellular senescence, oxidative stress, apoptosis, DNA damage, and cellular metabolism. Understanding the role of SIRTs in cardiovascular diseases opens new opportunities for therapeutic intervention with potential for preventing and treating cardiovascular disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Toxicology
Dareuosh Shackebaei, Mahvash Hesari, Soudabeh Ramezani-Aliakbari, Zohreh Hoseinkhani, Fatemeh Ramezani-Aliakbari
Summary: The study found that GA has protective effects against cardiac damage induced by ischemia/reperfusion in rats. It improves cardiac function by increasing antioxidant defense enzymes, reducing cell damage, and enhancing the expression of specific genes.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Paul W. Hotz, Stefan Mueller, Luca Mendler
Summary: SUMOylation is a transient posttranslational modification involving small-ubiquitin like modifiers that affect protein-protein interactions, enzymatic activity, and chromatin binding in key cellular processes. The equilibrium of SUMOylation and deSUMOylation is tightly controlled to ensure rapid kinetics and dynamic molecular switching of SUMO-target proteins.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yi Guo, Chanjun Lu, Ke Hu, Chuanqi Cai, Weici Wang
Summary: Cardiovascular diseases are a major cause of global mortality and disability, and targeting ferroptosis may provide a promising approach for treating these diseases.
Review
Pharmacology & Pharmacy
Joachim Neumann, Uwe Kirchhefer, Stefan Dhein, Britt Hofmann, Ulrich Gergs
Summary: This review discusses the pharmacological, structural, and functional relationships between H-2-histamine receptors and H-1-histamine receptors in the mammalian heart, focusing on their role in regulating heart force and rhythm, potential clinical applications in cardiac diseases, and the effects on cardiac arrhythmias. It also highlights novel findings, limitations in current understanding, and suggests future research directions, including the possible development of cardiomyocyte-specific H-2-histamine receptor agonists and antagonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Wenguang Chang, Peifeng Li
Summary: Myocardial injury is a leading cause of death in heart disease patients. Recent studies have shown that mesenchymal stromal cells (MSCs) and their secretomes, specifically small extracellular vesicles (sEVs), have therapeutic effects on cardiac injury. MSCs are able to differentiate into various cell types, making them suitable for cardiac repair, but sEVs have shown better therapeutic effects and easier quality control. This review summarizes the current knowledge and discusses scientific issues in the development of MSC and MSC-sEV-based therapies for cardiac injury.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Felipe Salazar-Ramirez, Roberto Ramos-Mondragon, Gerardo Garcia-Rivas
Summary: Ca2+plays a crucial role in mitochondrial function, and the communication between mitochondria and SR is essential for cellular energy production and signaling. The balance between mitochondria and SR maintains normal cellular function, and any imbalance can lead to abnormal excitability of cardiac cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stefan Heber, Paul M. Haller, Attila Kiss, Bernhard Jaeger, Kurt Huber, Michael J. M. Fischer
Summary: This study found that methylglyoxal (MG) levels increase in the plasma of humans following acute myocardial infarction (AMI), and this increase is associated with a decrease in left ventricular ejection fraction (LVEF). MG levels increase after reperfusion and gradually decrease after 24 hours. The increase in MG is largely independent of cardiac necrosis markers, suggesting the presence of mechanisms independent of myocardial necrosis. The study also found that the increase in MG explains 23% of the variation in LVEF. Therefore, inhibiting MG generation or scavenging MG may be a novel therapeutic strategy to target post-AMI myocardial remodeling and dysfunction.
Article
Biochemistry & Molecular Biology
Clara Hoebart, Attila Kiss, Patrick M. Pilz, Petra L. Szabo, Bruno K. Podesser, Michael J. M. Fischer, Stefan Heber
Summary: This study aims to investigate the effects of TRPA1 activation, inhibition, or absence on infarcts and explore the underlying mechanisms. In vivo experiments showed no significant differences in infarct size among different TRPA1 activation or inhibition groups compared to the control group. In vitro experiments demonstrated that the presence of sensory neurons, partly dependent on TRPA1, increased the survival probability of cardiomyocytes challenged by ischemia-reperfusion. These findings raise doubts about the potential of TRPA1 as a promising target for reducing myocardial damage within a 24-hour period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fabian Dorninger, Attila Kiss, Peter Rothauer, Alexander Stiglbauer-Tscholakoff, Stefan Kummer, Wedad Fallatah, Mireia Perera-Gonzalez, Ouafa Hamza, Theresa Koenig, Michael B. Bober, Tiscar Cavalle-Garrido, Nancy E. Braverman, Sonja Forss-Petter, Christian Pifl, Jan Bauer, Reginald E. Bittner, Thomas H. Helbich, Bruno K. Podesser, Hannes Todt, Johannes Berger
Summary: The deficiency in ether lipids can cause severe symptoms in humans and the mouse model has been used to study the pathophysiology of the disease. However, the exact role of ether lipids in the cardiac tissue is still unknown. This study found that ether lipid deficiency can lead to cardiac abnormalities in both mice and human patients, but the manifestations are heterogeneous and differ between the two.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Attila Kiss, Gyorgy L. Nadasy, Alexander Fees, Zsuzsanna Arnold, Ibrahim Aykac, Christopher Dostal, Gabor T. Szabo, Petra Lujza Szabo, Maria Szekeres, Peter Pokreisz, Laszlo Hunyady, Bruno K. Podesser
Summary: Diabetes induces geometric alterations in the coronary resistance artery network, while TNC deletion prevents abnormal vascular morphologies caused by diabetes. Diabetes promotes vascular remodeling and vasculogenesis at specific positions in the coronary vasculature.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Bettina Kronsteiner, Max Haberbusch, Philipp Aigner, Anne-Margarethe Kramer, Patrick M. Pilz, Bruno K. Podesser, Attila Kiss, Francesco Moscato
Summary: To understand the cardiac responses to vagus nerve stimulation (VNS), an ex-vivo Langendorff-perfused rabbit heart model with intact vagal innervation was used. This model demonstrated nerve excitability for about 5 hours ex-vivo. The charges required for HR reduction were lower in the ex-vivo model compared to in-vivo experiments, indicating the feasibility of this model to study the cardiac effects of VNS.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Max Lenz, Attila Kiss, Patrick Haider, Manuel Salzmann, Mira Brekalo, Konstantin A. A. Krychtiuk, Ouafa Hamza, Kurt Huber, Christian Hengstenberg, Bruno K. K. Podesser, Johann Wojta, Philipp J. J. Hohensinner, Walter S. S. Speidl
Summary: Ischaemia-reperfusion injury (IRI) is a challenging issue in acute cardiac care, and subsequent heart failure is a severe long-term consequence. In this study, they aimed to investigate the involvement of Toll-like receptor 9 (TLR9) in neutrophil activation and chemotaxis, which may be a target for modulating IRI. The results showed that inhibition of TLR9 led to increased neutrophil infiltration and tissue damage.
Article
Cardiac & Cardiovascular Systems
Marta Sarkoezy, Simon Watzinger, Zsuzsanna Z. A. Kovacs, Eylem Acar, Fanni Marvanykoevi, Gergo Szucs, Gulsum Yilmaz Lauber, Zsolt Galla, Andrea Siska, Imre Foldesi, Attila Fintha, Andras Kriston, Ferenc Kovacs, Peter Horvath, Bence Kovari, Gabor Cserni, Tibor Krenacs, Petra Lujza Szabo, Gabor Tamas Szabo, Peter Monostori, Karin Zins, Dietmar Abraham, Tamas Csont, Peter Pokreisz, Bruno K. Podesser, Attila Kiss
Summary: Chronic kidney disease is a prevalent health issue affecting 10% to 12% of the global population. In the context of uremic cardiomyopathy, dysregulation of neuregulin-10 signaling in the heart has been identified as a contributing factor to heart failure. A study using a nephrectomy-induced model of chronic kidney disease demonstrated that systemically administered recombinant human neuregulin-10 for a duration of 10 days could alleviate the progression of uremic cardiomyopathy and kidney dysfunction. These promising preclinical findings call for further clinical studies to validate the beneficial effects of recombinant human neuregulin-10 in patients with chronic kidney disease.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Physiology
Petra Lujza Szabo, Jessica Marksteiner, Janine Ebner, Christopher Dostal, Bruno K. Podesser, Jakob Sauer, Helmut Kubista, Hannes Todt, Benjamin Hackl, Xaver Koenig, Attila Kiss, Karlheinz Hilber
Summary: The study showed that the muscular dystrophies caused by dystrophin deficiency can lead to impaired cardiac function and arrhythmias, increasing disease morbidity and mortality. Impaired calcium handling in ventricular cardiomyocytes has been identified as a causal factor for complications in the dystrophic heart, and the drug ivabradine has been found to improve calcium handling and contractile performance in dystrophic cardiomyocytes. The administration of ivabradine significantly improved cardiac function and increased intracellular calcium transients in dystrophin-deficient rats.
PHYSIOLOGICAL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Zsofia Onodi, Petra Lujza Szabo, Daniel Kucsera, Peter Pokreisz, Christopher Dostal, Karlheinz Hilber, Gavin Y. Oudit, Bruno K. Podesser, Peter Ferdinandy, Zoltan V. Varga, Attila Kiss
Summary: Duchenne muscular dystrophy (DMD) is a muscle wasting disease characterized by difficulty moving and premature death, mainly due to heart failure. Inflammation is thought to play a role in the disease progression, but the specific mechanisms are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Artificial Intelligence
Wei-Ting Chang, Bor-Shing Lin, Yung-Lin Chen, Heng-Yin Chen, Chengyu Liu, Yi-Ting Hwang, Bor-Shyh Lin
Summary: This article introduces a novel smart clothing that can automatically detect cardiovascular diseases in daily life. By using capacitive electrodes, this smart clothing can prevent skin irritation and discomfort and can be adjusted according to different body sizes. The front-end circuit of this smart clothing can real-time extract ECG features and detect cardiovascular disease states. The proposed FPGA architecture is beneficial for future improvements in cardiovascular disease algorithms.
IEEE TRANSACTIONS ON HUMAN-MACHINE SYSTEMS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Tania Martins-Marques, Goncalo Coutinho, Attila Kiss
Article
Geriatrics & Gerontology
Hoa Dinh, Zsuzsanna Z. A. Kovacs, Merse Kis, Klaudia Kupecz, Anita Sejben, Gergo Szucs, Fanni Marvanykovi, Andrea Siska, Marah Freiwan, Szonja Polett Posa, Zsolt Galla, Katalin Eszter Ibos, Eva Bodnar, Guelsuem Yilmaz Lauber, Ana Isabel Antunes Goncalves, Eylem Acar, Andras Kriston, Ferenc Kovacs, Peter Horvath, Zsolt Bozso, Gabor Toth, Imre Foeldesi, Peter Monostori, Gabor Cserni, Bruno K. Podesser, Andrea Lehoczki, Peter Pokreisz, Attila Kiss, Laszlo Dux, Krisztina Csabafi, Marta Sarkozy
Summary: This study investigated the impact of KP-13 on the trajectory of CKD and uremic cardiomyopathy. The results showed that KP-13 increased blood pressure, accentuated diastolic dysfunction, and intensified CKD-associated markers. However, KP-13 did not exacerbate circulatory uremic toxin levels, renal inflammation, or fibrosis markers, while the higher dose of KP-13 correlated with reduced heart wall thickness and increased expression of inflammatory, fibrosis, and apoptosis markers.
Review
Cardiac & Cardiovascular Systems
Michael Kest, Andras Agoston, Gabor Tamas Szabo, Attila Kiss, Aron Uveges, Daniel Czuriga, Andras Komocsi, Istvan Hizoh, Zsolt Koszegi
Summary: This study aims to identify and analyze angiography-derived indices of microvascular resistance that have been validated against an invasive reference method. The study finds that combined angiography- and pressure-based methods provide a more reliable assessment of microvascular resistance compared to methods relying solely on angiography.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)