BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation

Biomolecular condensates and cancer

(2021) Ann Boija et al.   CANCER CELL

Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression

(2021) Bin Zheng et al.   GENES & DEVELOPMENT

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies

(2021) Mariesa J. Slaughter et al.   Cell Reports

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

(2021) Young-Kwon Park et al.   Nature Communications

MED1 is a lipogenesis coactivator required for postnatal adipose expansion

(2021) Younghoon Jang et al.   GENES & DEVELOPMENT

A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation

(2021) Constantine Mylonas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae

(2021) Rafal Donczew et al.   eLife

ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells

(2021) Zhong-Yan Cheng et al.   Frontiers in Immunology

Mechanisms of Smoothened Regulation in Hedgehog Signaling

(2021) Jie Zhang et al.   Cells

HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs

(2021) Yang Yang et al.   NUCLEIC ACIDS RESEARCH

Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance

(2020) Mingjun Bi et al.   NATURE CELL BIOLOGY

Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells

(2020) Zengqi Wen et al.   NUCLEIC ACIDS RESEARCH

lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation

(2020) Kaveh Daneshvar et al.   NATURE CELL BIOLOGY

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

(2020) Drake S. Edwards et al.   Cell Reports

LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA

(2019) Keiichi Izumikawa et al.   NUCLEIC ACIDS RESEARCH

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

(2019) Jae Jin Kim et al.   GENES & DEVELOPMENT

BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition

(2018) Guillaume P. Andrieu et al.   MOLECULAR CANCER RESEARCH

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

(2018) Jean-Philippe Lambert et al.   MOLECULAR CELL

DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing

(2018) Prasun Chakraborty et al.   Nature Communications

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

(2017) Ka Lung Cheung et al.   MOLECULAR CELL

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis

(2017) Binbin Lai et al.   NUCLEIC ACIDS RESEARCH

SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells

(2017) Moe Tokue et al.   Stem Cell Reports

Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition

(2016) Chaochen Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs

(2016) Lauren E. Surface et al.   Cell Reports

Functions of BET proteins in erythroid gene expression

(2015) Aaron J. Stonestrom et al.   BLOOD

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma

(2015) Chiara Vardabasso et al.   MOLECULAR CELL

Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes

(2014) Jill M. Dowen et al.   CELL

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

(2014) Junwei Shi et al.   MOLECULAR CELL

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation

(2013) Kyong-Rim Kieffer-Kwon et al.   CELL

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

(2013) Shannon M. Lauberth et al.   CELL

Genome-wide localization of small molecules

(2013) Lars Anders et al.   NATURE BIOTECHNOLOGY

The RNA Pol II Elongation Factor Ell3 Marks Enhancers in ES Cells and Primes Future Gene Activation

(2012) Chengqi Lin et al.   CELL

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

(2012) Daniel C. Berwick et al.   HUMAN MOLECULAR GENETICS

mRNA Decapping Factors and the Exonuclease Xrn2 Function in Widespread Premature Termination of RNA Polymerase II Transcription

(2012) Kris Brannan et al.   MOLECULAR CELL

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

(2012) Warren A. Whyte et al.   NATURE

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

(2012) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins

(2012) Gary LeRoy et al.   GENOME BIOLOGY

Control of Embryonic Stem Cell Lineage Commitment by Core Promoter Factor, TAF3

(2011) Zhe Liu et al.   CELL

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

GABAergic Neuron Deficit As An Idiopathic Generalized Epilepsy Mechanism: The Role Of BRD2 Haploinsufficiency In Juvenile Myoclonic Epilepsy

(2011) Libor Velíšek et al.   PLoS One

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Brd2disruption in mice causes severe obesity without Type 2 diabetes

(2009) Fangnian Wang et al.   BIOCHEMICAL JOURNAL

The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis

(2009) Aron Gyuris et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse

(2009) Enyuan Shang et al.   DEVELOPMENTAL DYNAMICS

The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription

(2008) Gary LeRoy et al.   MOLECULAR CELL