Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease

(2022) Brage Brakedal et al.   Cell Metabolism

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

(2021) Xuan Sun et al.   Nature Communications

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

(2021) Miriama Kruta et al.   Cell Stem Cell

Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration

(2021) Le Qi et al.   Cell Stem Cell

Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells

(2020) Bernadette A. Chua et al.   Cell Stem Cell

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

(2020) Lorena Hidalgo San Jose et al.   Cell Reports

Hematopoietic Stem Cell Metabolism during Development and Aging

(2020) Ayako Nakamura-Ishizu et al.   DEVELOPMENTAL CELL

Adaptive endoplasmic reticulum stress signalling via IRE1α–XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells

(2019) Lu Liu et al.   NATURE CELL BIOLOGY

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

(2019) Nicola Vannini et al.   Cell Stem Cell

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

(2018) Ronald C. Wek   Cold Spring Harbor Perspectives in Biology

Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B

(2018) Agnieszka Krzyzosiak et al.   CELL

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

(2018) Courtney L. Jones et al.   CANCER CELL

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

(2017) Elena Ansó et al.   NATURE CELL BIOLOGY

Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal

(2016) Victoria Zismanov et al.   Cell Stem Cell

Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver

(2016) Valgardur Sigurdsson et al.   Cell Stem Cell

The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism

(2016) Pengxu Qian et al.   Cell Stem Cell

The mitochondrial metabolic checkpoint and aging of hematopoietic stem cells

(2016) Mary Mohrin et al.   CURRENT OPINION IN HEMATOLOGY

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

(2016) Robert A.J. Signer et al.   GENES & DEVELOPMENT

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation

(2016) Y. Taya et al.   SCIENCE

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells

(2015) Xiongwei Cai et al.   Cell Stem Cell

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

(2014) Ying-Hua Wang et al.   CELL

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

(2014) Peter van Galen et al.   NATURE

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia

(2013) Atsushi Hirao et al.   CANCER SCIENCE

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

(2013) Wen-Mei Yu et al.   Cell Stem Cell

Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells

(2013) Marie Le Bouteiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

(2012) Min Yuan et al.   Nature Protocols

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

(2010) Sushma Gurumurthy et al.   NATURE

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

(2010) Boyi Gan et al.   NATURE

Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance

(2009) Bing Luan et al.   NATURE