Cebranopadol: novel dual opioid/NOP receptor agonist analgesic

Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility

(2016) Nurulain T. Zaveri   JOURNAL OF MEDICINAL CHEMISTRY

Unrelieved Pain: A Crisis

(2016) Barry J Sessle   Pain Research & Management

Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates

(2015) H Ding et al.   BRITISH JOURNAL OF PHARMACOLOGY

Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys

(2015) A Rizzi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats

(2015) Laura Micheli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cebranopadol: a first-in-class potent analgesic agent with agonistic activity at nociceptin/orphanin FQ and opioid receptors

(2015) Kinga Sałat et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Estimates of Pain Prevalence and Severity in Adults: United States, 2012

(2015) Richard L. Nahin   JOURNAL OF PAIN

Single- and multiple-dose pharmacokinetics of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) compared with immediate-release hydrocodone bitartrate/ibuprofen and immediate-release tramadol HCl/acetaminophen

(2015) Krishna Devarakonda et al.   Journal of Pain Research

Buprenorphine–Naloxone Therapy in Pain Management

(2014) Kelly Yan Chen et al.   ANESTHESIOLOGY

A mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks

(2014) Eric Erbs et al.   Brain Structure & Function

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth, a Cochrane systematic review

(2014) E. Bailey et al.   BRITISH DENTAL JOURNAL

Challenges for opioid receptor nomenclature: IUPHAR Review 9

(2014) Brian M Cox et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin

(2014) Liping Cao et al.   GENE

The clinical analgesic efficacy of buprenorphine

(2014) R. B. Raffa et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol

(2014) Stefan Schunk et al.   ACS Medicinal Chemistry Letters

Serotonin, 5HT1 agonists, and migraine

(2014) Greg Dussor   Current Opinion in Supportive and Palliative Care

Mitigating the Cardiovascular and Renal Effects of NSAIDs: Table 1

(2013) Rodolfo V. Curiel et al.   PAIN MEDICINE

The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence

(2013) Jeffrey M. Witkin et al.   PHARMACOLOGY & THERAPEUTICS

Miotic and subject-rated effects of therapeutic doses of tapentadol, tramadol, and hydromorphone in occasional opioid users

(2013) William W. Stoops et al.   PSYCHOPHARMACOLOGY

Mechanistic and functional differentiation of tapentadol and tramadol

(2012) Robert B Raffa et al.   EXPERT OPINION ON PHARMACOTHERAPY

Treating Acute Pain in Light of the Chronification of Pain

(2012) Joseph V. Pergolizzi et al.   Pain Management Nursing

Pain as a global public health priority

(2011) Daniel S Goldberg et al.   BMC PUBLIC HEALTH

Update on Pain Management in Sickle Cell Disease

(2011) Samir K. Ballas   HEMOGLOBIN

Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: Examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen/paracetamol combinations after third molar extraction

(2011) Andrew R. Moore et al.   PAIN

Access to pain treatment as a human right

(2010) Diederik Lohman et al.   BMC Medicine

Effects of the NOP receptor agonist Ro65-6570 on the acquisition of opiate- and psychostimulant-induced conditioned place preference in rats

(2010) Kris Rutten et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recently patented and promising ORL-1 ligands: where have we been and where are we going?

(2010) Tally M Largent-Milnes et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

What do we (not) know about how paracetamol (acetaminophen) works?

(2010) K. Toussaint et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

The Determination and Application of Fixed-Dose Analgesic Combinations for Treating Multimodal Pain

(2010) Robert B. Raffa et al.   JOURNAL OF PAIN

Selective inhibition of the NOP receptor in the ventrolateral periaqueductal gray attenuates the development and the expression of tolerance to morphine-induced antinociception in rats

(2010) Giovanna M. Scoto et al.   PEPTIDES

Antinociceptive Effects of Nociceptin/Orphanin FQ Administered Intrathecally in Monkeys

(2009) Mei-Chuan Ko et al.   JOURNAL OF PAIN

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced by Mixed Nociceptin/Orphanin FQ/ -Opioid Receptor Agonists

(2009) T. V. Khroyan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/ -Opioid Receptor Ligands: Implications for Therapeutic Applications

(2009) L. Toll et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Addressing Patients' Concerns about Pain Management and Addiction Risks

(2009) Joy R. Goebel et al.   Pain Management Nursing

Common Chronic Pain Conditions in Developed and Developing Countries: Gender and Age Differences and Comorbidity With Depression-Anxiety Disorders

(2008) Adley Tsang et al.   JOURNAL OF PAIN

The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

(2008) David G. Lambert   NATURE REVIEWS DRUG DISCOVERY