From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension

(2019) Zhen Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of furyl/thienyl β-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect

(2018) Hongbo Zheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure–Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension

(2018) Deyan Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease

(2017) Jole Fiorito et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension

(2017) Deyan Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The molecular targets of approved treatments for pulmonary arterial hypertension

(2015) Marc Humbert et al.   THORAX

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53

(2013) Mohammad Abdel-Halim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Drugs for Allosteric Sites on Receptors

(2011) Cody J. Wenthur et al.   Annual Review of Pharmacology and Toxicology

PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel

(2010) Yong Zhang et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE