Article
Biochemistry & Molecular Biology
Hwi Gon Kim, Ye Seon Lim, Seonyeong Hwang, Hye-Yoon Kim, Yuseok Moon, Yong Jung Song, Yong-Jin Na, Sik Yoon
Summary: DEHP, a commonly used plasticizer, may be linked to the development of endometriosis by inducing cell proliferation, migration, inflammation, and stemness through the TGF-β/Smad signaling pathway, providing novel insights into the pathogenesis of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agricultural Engineering
Birgitta Narindri Rara Winayu, Ko Tung Lai, Hsin Ta Hsueh, Hsin Chu
Summary: This study examined the performance of TCL-1 cultivation in swine wastewater under various light intensities, treatment types, and initial biomass concentrations. The main focus was on pigment production and optimal extraction methods. Results showed that different treatment types had different effects on biomass increase and pigment production, while different extraction methods also influenced pigment yields.
BIORESOURCE TECHNOLOGY
(2021)
Article
Food Science & Technology
Mohammad-Taghi Golmakani, Farzaneh Kiani, Mohammad Mahdi Hajjari, Niloufar Sharif, Mahboubeh Fazaeli, Seyed Mohammad Hashem Hosseini
Summary: Electrospinning was used to develop zein fibers containing phycocyanin and aqueous-ethanolic extract of Spirulina (AEES) for packaging walnut samples. The fibers showed optimal outcomes at a concentration of 0.3 g/mL under specific conditions. The phycocyanin-loaded and AEES-loaded zein fibers exhibited similar morphology and diameter, and effectively reduced bacteria growth and oxidation in the walnut samples.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nguyen-Tuong Ho, Shu-Wei Lin, Yi-Rong Lee, Chii-Ruey Tzeng, Shu-Huei Kao
Summary: OPNb and OPNc are overexpressed in endometriosis and adenomyosis, and CD44v and the epithelial-mesenchymal transition (EMT) process are also upregulated. Overexpression of OPNb and OPNc splice variants leads to morphological changes, actin remodeling, cell proliferation, cell migration, and EMT through binding with CD44 and alpha v beta 3, subsequently activating the PI3K and NF-kappa B pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Wubshet Asnake Metekia, Beyza Hatice Ulusoy
Summary: This study investigates the antibacterial activity of Spirulina platensis extract on food pathogens. The results show that the extract has a significant inhibitory effect on the bacterial load of stored fish fillets. The use of artificial intelligence models further supports the antimicrobial effectiveness of Spirulina extract.
SCIENTIFIC REPORTS
(2023)
Article
Horticulture
Jeet Varia, Cedric Kamaleson, Leonard Lerer
Summary: Vertical farming is seen as a potential solution for providing high-quality, accessible, and environmentally friendly nutrition for urban populations, but innovative technologies are needed to industrialize and expand its production beyond leafy greens and fruits. Research into biostimulation, such as using phycocyanin-rich Spirulina extract, shows promising results in promoting plant growth, improving crop yield, and potentially enhancing prebiotic activity in hydroponic vertical farming.
SCIENTIA HORTICULTURAE
(2022)
Article
Oncology
Hsin-Yuan Chen, Yi-Fen Chiang, Jia-Syuan Huang, Tsui-Chin Huang, Yin-Hwa Shih, Kai-Lee Wang, Mohamed Ali, Yong-Han Hong, Tzong-Ming Shieh, Shih-Min Hsia
Summary: The study aimed to investigate the anti-metastatic potential of ISL on endometrial cancer by reversing EMT through targeting the TGF-beta/Smad signaling pathway. Results from in vitro and in vivo experiments demonstrated that ISL efficiently inhibited cell migration, reduced metastasis, and altered the expression of related proteins.
Article
Biochemistry & Molecular Biology
Yoshiko Hashimoto, Tomoko Tsuzuki-Nakao, Naoko Kida, Yoshiyuki Matsuo, Tetsuo Maruyama, Hidetaka Okada, Kiichi Hirota
Summary: The endometrium undergoes repeated changes during the menstrual cycle, and chronic endometritis can lead to implantation failure and miscarriage. In this study, the effects of inflammatory cytokines, hypoxia-inducible factor (HIF), and inflammation on endometrial epithelial cells were investigated. The results showed that pro-inflammatory factors and hypoxia activated HIF-1 and promoted epithelial-mesenchymal transition (EMT) in endometrial epithelial cells.
Article
Cell Biology
Zhenhua Zhou, Huiyan Wang, Xiwen Zhang, Minmin Song, Simin Yao, Peipei Jiang, Dan Liu, Zhiyin Wang, Haining Lv, Ruotian Li, Ying Hong, Jianwu Dai, Yali Hu, Guangfeng Zhao
Summary: Defective autophagy plays an important role in endometrial fibrosis by regulating EEC-EMT through the DIO2-MAPK/ERK-MTOR pathway.
Article
Developmental Biology
Xi Cheng, Yu Zhang, Jinzhao Ma, Shuxian Wang, Rujun Ma, Xie Ge, Wei Zhao, Tongmin Xue, Li Chen, Bing Yao
Summary: The study found that NLRP3 is highly expressed in the human endometrium and transcriptionally up-regulated by estradiol through estrogen receptor beta. Additionally, NLRP3 promotes embryo implantation and epithelial-mesenchymal transition of Ishikawa cells through inflammasome-dependent and inflammasome-independent pathways, providing a novel insight into endometrial receptivity and embryo implantation.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Gastroenterology & Hepatology
Tianhao Weng, Dong Yan, Danrong Shi, Miaojin Zhu, Yizhi Liu, Zhigang Wu, Taoming Tang, Linwei Zhu, Hong Zhang, Hangping Yao, Lanjuan Li
Summary: The study reveals that MSP is an important biomarker in the progression of liver cirrhosis and can be utilized for patient prognostication. The MSP-RON pathway promotes hepatocytes EMT and fibrosis progression via the TGF-beta related pathway. Potential therapeutic strategies for liver cirrhosis targetting the MSP/RON pathway have been identified.
LIVER INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Katrien De Clercq, Rieta Van Bree, Katrien Luyten, Daniela Annibali, Frederic Amant, Sileny Han, Els Van Nieuwenhuysen, Thais Baert, Karen Peeraer, Thomas Voets, Toon Van Gorp, Joris Vriens
Summary: The study revealed a strong association between TRP channel mRNA expression and cellular phenotypes in the endometrium. Specifically, TRPV2 and TRPC1 mRNA expression correlated with the mesenchymal phenotype, while TRPM4 mRNA expression was associated with the epithelial phenotype. These findings suggest that TRP channels could serve as biomarkers for high-risk endometrial cancer and potential targets for treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Ha Young Jang, Soo-Jin Kim, Kyu-Sang Park, Jeong Hun Kim
Summary: Degenerative changes of RPE triggered by TGF-beta 2 and oxidative stress play a critical role in AMD progression. The expression of antiaging protein alpha-klotho declines with age, increasing the risk of age-related diseases. Alpha-klotho protects against TGF-beta 2-induced RPE degeneration and EMT both in vitro and in vivo. It inhibits TGF-beta 2 signaling, EMT, oxidative stress, and senescence-associated signaling.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Tzu-Yin Chen, Chia-Hao Liu, Tsung-Hsien Chen, Mei-Ru Chen, Shan-Wen Liu, Pinpin Lin, Kurt Ming-Chao Lin
Summary: The role of epithelial-mesenchymal transition in lung diseases and cancer related to cigarette smoking is significant. Adipose-derived stem cell-conditioned medium shows protective effects against cigarette smoke-induced cell death and EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ching-Chung Ko, Yao-Yu Hsieh, Pei-Ming Yang
Summary: Epithelial-to-mesenchymal transition (EMT) is a biological process that promotes cancer cell dissemination and drug resistance. This study revealed that overexpression of MIR31HG in pancreatic ductal adenocarcinoma (PDAC) patients is associated with poorer disease-free survival, as well as upregulation of genes related to TGF beta signaling and EMT. In vitro experiments further demonstrated that TGF beta induces MIR31HG expression and knockdown of MIR31HG reverses TGF beta-induced EMT phenotypes and cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Ko-Chieh Huang, Yi-Fen Chiang, Tsui-Chin Huang, Hsin-Yuan Chen, Po-Han Lin, Mohamed Ali, Shih-Min Hsia
Summary: This study investigates the protective effects of capsaicin against cisplatin-induced muscle loss and atrophy. The study demonstrates that capsaicin can restore the balance between protein synthesis and degradation pathways, ameliorate muscle atrophy induced by cisplatin, and improve muscle strength. Capsaicin also shows potential in alleviating oxidative stress and inflammation in muscle cells. These findings suggest that capsaicin may be a valuable therapeutic agent to prevent muscle loss and atrophy caused by cisplatin therapy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Yi-Fen Chiang, Ko-Chieh Huang, Hsin-Yuan Chen, Tsui-Chin Huang, Mohamed Ali, Hsin-Yi Chang, Tzong-Ming Shieh, Yin-Hwa Shih, Kai-Lee Wang, Yun-Ju Huang, Cheng-Pei Chung, Shih-Min Hsia
Summary: Obesity is a risk factor for cancer progression as it increases adipokine secretion. Visfatin, a novel adipokine highly expressed in cancer patients, is associated with breast cancer risk. In this study, the effect of visfatin on stemness-related properties in high-malignancy breast cancer cells was investigated. Visfatin treatment significantly increased sphere formation, protein expression of stemness markers, and angiogenesis markers. These effects were reduced by the visfatin inhibitor FK866. The results suggest that visfatin promotes breast cancer stemness and enriches the tumorigenic microenvironment.
Article
Food Science & Technology
Hong-Yu Lin, Cheng-Pei Chung, Shih-Min Hsia, Yu-Chia Chang, Wenchang Chiang, Yueh-Hsiung Kuo, Yun-Lian Lin
Summary: Lotus leaves contain valuable functional alkaloids that have inhibitory effects on free radicals and nitric oxide production. Five alkaloids were isolated and identified, with different compounds showing different activities. Compound 5, which accounted for a significant portion of total alkaloids, exhibited the highest DPPH radical-scavenging effect and also inhibited NO production through suppressing iNOS expression. The study suggests that alkaloid extracts from lotus leaves can be used as functional ingredients.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yin-Hwa Shih, Chieh-Chieh Chen, Yueh-Hsiung Kuo, Lih-Jyh Fuh, Wan-Chen Lan, Tong-Hong Wang, Kuo-Chou Chiu, Thanh-Hien Vu Nguyen, Shih-Min Hsia, Tzong-Ming Shieh
Summary: This study aimed to investigate the anticancer properties and mechanisms of CAPE and caffeamide derivatives in oral squamous cell carcinoma cells. The results showed that 26G and 36M exhibited stronger cytotoxicity in SAS cells. Additionally, treatment with 26G and 36M inhibited malignant phenotypes through the activation of autophagic signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Shih Min Hsia
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Yi-Chun Chen, Yi-Fen Chiang, Ying-Jiun Lin, Ko-Chieh Huang, Hsin-Yuan Chen, Nadia M. Hamdy, Tsui-Chin Huang, Hsin-Yi Chang, Tzong-Ming Shieh, Yun-Ju Huang, Shih-Min Hsia
Summary: This study aimed to evaluate the effects of vitamin D supplementation on relieving the symptoms of primary dysmenorrhea. A meta-analysis of randomized controlled trials showed that vitamin D treatment significantly reduced the pain level in individuals with dysmenorrhea. The results indicated that vitamin D supplementation is an alternative treatment for relieving the pain symptoms of dysmenorrhea.
Review
Cell Biology
Mohamed Ali, Michal Ciebiera, Somayeh Vafaei, Samar Alkhrait, Hsin-Yuan Chen, Yi-Fen Chiang, Ko-Chieh Huang, Stepan Feduniw, Shih-Min Hsia, Ayman Al-Hendy
Summary: Uterine fibroids are a significant benign neoplastic threat to women's health globally, affecting up to 80% of premenopausal women and causing symptoms such as heavy menstrual bleeding, pain, and infertility. Progesterone signaling is crucial for the development and growth of uterine fibroids, promoting cell proliferation through genetic and epigenetic pathways. This review discusses the role of progesterone signaling in uterine fibroid pathogenesis and explores the therapeutic potential of compounds that modulate progesterone signaling, including selective progesterone receptor modulator drugs and natural compounds. Further research is needed to ensure safety and understand the exact molecular mechanisms of selective progesterone receptor modulator drugs, while clinical trials are necessary to confirm the effectiveness of natural compounds as a potential long-term treatment option, particularly for women planning pregnancy.
Article
Biochemistry & Molecular Biology
Yi-Fen Chiang, Ngan Thi Kim Nguyen, Shih-Min Hsia, Hsin-Yuan Chen, Shyh-Hsiang Lin, Ching- Lin
Summary: Hypoglycemia is a potential factor for neurodegenerative diseases. The ketone body, beta-hydroxybutyrate (BHB), may protect against hypoglycemia-induced injury.
Article
Medicine, Research & Experimental
Yi -Fen Chiang, I. -Cheng Lin, Ko-Chieh Huang, Hsin-Yuan Chen, Mohamed Ali, Yun-Ju Huang, Shih-Min Hsia
Summary: This study investigated the therapeutic effect of caffeic acid on PCOS and its underlying molecular mechanism. The results showed that caffeic acid could inhibit oxidative stress and improve PCOS-related complications by modulating ER stress.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Mohamed Ali, Michal Ciebiera, Marta Wlodarczyk, Samar Alkhrait, Elise Maajid, Qiwei Yang, Shih-Min Hsia, Ayman Al-Hendy
Summary: Uterine fibroids are the most common benign neoplasm in reproductive age women, and current treatment options have limitations. There is an urgent need for safe and effective non-surgical treatments.
Review
Pharmacology & Pharmacy
Michal Ciebiera, Obianuju Sandra Madueke-Laveaux, Stepan Feduniw, Mara Ulin, Robert Spaczynski, Magdalena Zgliczynska, Monika Baczkowska, Elzbieta Zarychta, Tomasz Lozinski, Mohamed Ali, Ayman Al-Hendy
Summary: Uterine fibroids are commonly seen in women of childbearing age. Hormonal therapy, particularly the use of GnRH analogs, is widely used for treatment. Further research and development of new release systems or methods of administration, as well as the search for drugs that can decrease side effects when combined with GnRH analogs, is crucial.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Somayeh Vafaei, Michal Ciebiera, Mervat M. Omran, Mohammad Mousaei Ghasroldasht, Qiwei Yang, Tanya Leake, Rochelle Wolfe, Mohamed Ali, Ayman Al-Hendy
Summary: Understanding the risk factors and implementing secondary prevention measures for uterine fibroids are crucial for early detection, preserving quality of life, and reducing unnecessary surgical interventions. The current approach of watchful observation for early disease is considered a missed opportunity, and the ESCAPE method provides a simple, affordable, and safe alternative to prevent the progression of uterine fibroids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Thanh-Hien Vu Nguyen, Kuo-Chou Chiu, Yin-Hwa Shih, Chung-Ji Liu, Tran Van Bao Quach, Shih-Min Hsia, Yi-Hung Chen, Tzong-Ming Shieh
Summary: This animal study aimed to assess the efficacy of electroacupuncture (EA) as a means of preventing xerostomia induced by 5-fluorouracil (5-FU). The results showed that EA treatment can prevent 5-FU damage to the salivary gland, increase salivary flow rate and salivary gland weight, and decrease inflammation and tumor necrosis factor expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qiwei Yang, Mohamed Ali, Lindsey S. Trevino, Aymara Mas, Nahed Ismail, Ayman Al-Hendy
Summary: The developmental exposure to the endocrine-disrupting chemical, diethylstilbestrol (DES), activates inflammatory pathways in myometrial stem cells (MMSCs), which are the origin of uterine fibroids (UFs), leading to a hyper-inflammatory phenotype and an increased risk of hormone-dependent diseases. The epigenetic mechanisms involving mixed-lineage leukemia protein-1 (MLL1) and histone deacetylases (HDACs) play a key role in the reprogramming of MMSCs and the aberrant expression of inflammatory responsive genes (IRGs) induced by DES exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
