Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress

A randomized double-blinded placebo-controlled clinical trial on protective effects of pentoxifylline on gentamicin nephrotoxicity in infectious patients

(2021) Seyed Ruhollah Mousavinasab et al.   Clinical and Experimental Nephrology

Pentoxifylline in diabetic kidney disease (VA PTXRx): protocol for a pragmatic randomised controlled trial

(2021) David J Leehey et al.   BMJ Open

Protective effect of cilastatin against diclofenac‐induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters

(2020) Xiaokui Huo et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vivo High-Content Screening in Zebrafish for Developmental Nephrotoxicity of Approved Drugs

(2020) Jens H. Westhoff et al.   Frontiers in Cell and Developmental Biology

A Neonatal Murine Escherichia coli Sepsis Model Demonstrates That Adjunctive Pentoxifylline Enhances the Ratio of Anti- vs. Pro-inflammatory Cytokines in Blood and Organ Tissues

(2020) Esther M. Speer et al.   Frontiers in Immunology

Long Noncoding RNA-H19 Contributes to Atherosclerosis and Induces Ischemic Stroke via the Upregulation of Acid Phosphatase 5

(2019) Yujing Huang et al.   Frontiers in Neurology

Nephroprotective Effect of Moringa Oleifera Seed Oil on Gentamicin-Induced Nephrotoxicity in Rats: Biochemical Evaluation of Antioxidant, Anti-inflammatory, and Antiapoptotic Pathways

(2019) C. O. Edeogu et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats

(2018) Quadri Kunle Alabi et al.   Applied Physiology Nutrition and Metabolism

Plasma neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease: Findings from the PREVEND prospective cohort study

(2018) Setor K. Kunutsor et al.   CLINICA CHIMICA ACTA

Diclofenac induced gastrointestinal and renal toxicity is alleviated by thymoquinone treatment

(2018) İlker Öngüç Aycan et al.   FOOD AND CHEMICAL TOXICOLOGY

Oxidative Stress and Renal Fibrosis: Recent Insights for the Development of Novel Therapeutic Strategies

(2018) Wenshan Lv et al.   Frontiers in Physiology

Role of TNF-α in Regulating the Exercise Pressor Reflex in Rats With Femoral Artery Occlusion

(2018) Jihong Xing et al.   Frontiers in Physiology

Mouse population-based evaluation of urinary protein and miRNA biomarker performance associated with cisplatin renal injury

(2017) Alison H Harrill et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Extracellular Signal–Regulated Kinase 1/2 Regulates Mouse Kidney Injury Molecule-1 Expression Physiologically and Following Ischemic and Septic Renal Injury

(2017) Justin B. Collier et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy

(2017) Yuan-Ye Qiu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protective effect of berberine on renal fibrosis caused by diabetic nephropathy

(2017) Zhong Li et al.   Molecular Medicine Reports

Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns

(2017) Esther M. Speer et al.   PEDIATRIC RESEARCH

Vinpocetine reduces diclofenac-induced acute kidney injury through inhibition of oxidative stress, apoptosis, cytokine production, and NF-κB activation in mice

(2017) Victor Fattori et al.   PHARMACOLOGICAL RESEARCH

Discovery and verification of urinary peptides in type 2 diabetes mellitus with kidney injury

(2016) Guangzhen Fu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Renoprotective effect of berberineviaregulating the PGE2-EP1-Gαq-Ca2+signalling pathway in glomerular mesangial cells of diabetic rats

(2016) Wei-Jian Ni et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1βand IL-18 and Arrests CKD

(2016) Hazel H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular dynamics investigations of regioselectivity of anionic/aromatic substrates by a family of enzymes: a case study of diclofenac binding in CYP2C isoforms

(2016) Ying-Lu Cui et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Ameliorative effects of pentoxifylline on NOS induced by diabetes in rat kidney

(2016) Mehmet Fatih Sönmez et al.   RENAL FAILURE

Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction

(2016) Mohammad Adil et al.   RENAL FAILURE

Antioxidant Effect of Berberine and its Phenolic Derivatives Against Human Fibrosarcoma Cells

(2015) Veerachai Pongkittiphan et al.   Asian Pacific Journal of Cancer Prevention

Berberine and neurodegeneration: A review of literature

(2015) Touqeer Ahmed et al.   Pharmacological Reports

Renoprotective effects of berberine as adjuvant therapy for hypertensive patients with type 2 diabetes mellitus: Evaluation via biochemical markers and color Doppler ultrasonography

(2015) PEIFENG DAI et al.   Experimental and Therapeutic Medicine

Association of Fluid Retention With Anemia and Clinical Outcomes Among Patients With Chronic Kidney Disease

(2015) S.-C. Hung et al.   Journal of the American Heart Association

Genotoxic response and oxidative stress induced by diclofenac, ibuprofen and naproxen inDaphnia magna

(2014) Leobardo Manuel Gómez-Oliván et al.   DRUG AND CHEMICAL TOXICOLOGY

Animal models of acute renal failure

(2014) Amrit Pal Singh et al.   Pharmacological Reports

Preventive effect of pentoxifylline on contrast-induced acute kidney injury in hypercholesterolemic rats

(2014) SHI-KUN YANG et al.   Experimental and Therapeutic Medicine

Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis

(2013) Robert Domitrović et al.   FOOD AND CHEMICAL TOXICOLOGY

Berberine Ameliorate Oxidative Stress and Astrogliosis in the Hippocampus of STZ-Induced Diabetic Rats

(2013) Hamid Kalalian Moghaddam et al.   MOLECULAR NEUROBIOLOGY

Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice

(2013) Rachel P.L. van Swelm et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A review of the potential protective effects of pentoxifylline against drug-induced nephrotoxicity

(2012) Zahra Nasiri-Toosi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Short-term Administration of Diclofenac Sodium Affects Renal Function After Laparoscopic Radical Nephrectomy in Elderly Patients

(2012) T. Mizuno et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Antiurolithic effect of berberine is mediated through multiple pathways

(2010) Samra Bashir et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies

(2010) Vishal S Vaidya et al.   NATURE BIOTECHNOLOGY

Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms

(2009) Todd W. Costantini et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more

(2009) J. V. Bonventre   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pentoxifylline in Ischemia-Induced Acute Kidney Injury in Rats

(2009) Alice S. Okumura et al.   RENAL FAILURE