Article
Chemistry, Physical
Merve Ilgar, Guelsen Baytemir, Nevin Tasaltin, Selim Guelluelue, Ibrahim Saffet Yesilyurt, Selcan Karakus
Summary: In this study, novel maca extract-coated CuO nanoparticles were prepared using a green and facile sonication method. The nanoparticles showed promising antimicrobial properties and could be used for dopamine detection.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Claudia Viegas, Ana B. Patricio, Joao Prata, Leonor Fonseca, Ana S. Macedo, Sofia O. D. Duarte, Pedro Fonte
Summary: Pancreatic cancer is a highly lethal cancer type and prompt diagnosis as well as effective treatments are lacking. Nanomedicine, with its smart nanocarrier systems for drug delivery, has the potential to enhance treatment efficacy and reduce toxicity. This review discusses the scientific advances in nano-based drug delivery systems for pancreatic cancer treatment, as well as their advantages and disadvantages.
Article
Medical Laboratory Technology
Fereshteh Rahdan, Fateme Bina, Elham Norouz Dolatabadi, Donya Shaterabadi, Seyyed Hossein Khatami, Yousof Karami, Nafiseh Dorosti, Mortaza Taheri-Anganeh, Peyman Asadi, Rahmatollah Soltani, Mohammad Reza Pashaei, Ahmad Movahedpour
Summary: Pancreatic cancer is a highly lethal malignancy globally. MicroRNAs can serve as sensitive biomarkers for accurate diagnosis of various diseases, including cancer. This paper provides an overview of nanomaterial-enhanced miR-based electrochemical biosensors in the detection of pancreatic cancer, discussing both labeled and label-free approaches, as well as enzyme-based and enzyme-free methods.
CLINICA CHIMICA ACTA
(2023)
Review
Biotechnology & Applied Microbiology
Hossein Kamali, Shiva Golmohammadzadeh, Hamed Zare, Rahim Nosrati, Mohammad Fereidouni, Hossein Safarpour
Summary: This article outlines the research developments on the potential of DNAzymes-based aptasensors for cancer biomarker detection, and introduces the strategies of using nanomaterials and nanoparticles to improve detection limit and sensitivity.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhongchao Zhao, Andrea Simms, Nicole F. Steinmetz
Summary: This study utilizes tobacco mosaic virus (TMV) protein nanotubes as drug carriers to deliver platinum therapies to ovarian tumors, increasing efficacy and maintaining safety. It demonstrates superior efficacy compared to free drugs in mouse models and may induce immune response against tumors.
Article
Mathematical & Computational Biology
Namita Sharma, Sudha Srivastava
Summary: This work presents a miRNA-based electrochemical biosensor for detecting miRNA30e, a biomarker for pancreatic cancer. The biosensor showed high sensitivity and a wide detection range, making it a promising tool for early cancer detection.
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Shen Hui Min, Wang Lei, Chen Jia Jun, Zhang Shao Yan, Yang Xu Guang, Zhang Tong, Zheng Pei Yong, Lu Zhen Hui, Huang Xing
Summary: This paper reviews the advantages of various multifunctional nanoparticles in the treatment of lung cancer, including the use of nanoparticles loaded with anti-cancer drugs to deliver to lung cancer sites, enhancing drug half-life, improving anti-cancer drug efficacy, and reducing side effects. The delivery mode of nanoparticles with superior pharmacokinetic properties in the in vivo circulation enhances the half-life of the drug and provides tissue-targeted selectivity and the ability to overcome biological barriers, bringing a revolution in the field of oncology.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Mohammad Mahdi Eshaghi, Erfan Rahmani, Narges Ajalli, Shohreh Bakhshi, Helia Mirkhaef, Maryam Vahdat Lasemi, Abbas Rahdar, Razieh Behzadmehr, Ana M. Diez-Pascual
Summary: This review summarizes different drug delivery systems for cisplatin and compares their performance and potential. Stimuli-responsive systems are highlighted for enhanced drug delivery. Additionally, systems with co-delivery capabilities are discussed in detail.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Ali Mohammadpour-Haratbar, Yasser Zare, Kyong Yop Rhee
Summary: Breast cancer is one of the three most common and deadly cancers among women, and early detection plays a crucial role in improving treatment and survival rates. Biosensors have gained significant attention for their high sensitivity, simplicity, low cost, and low detection limit in the early diagnosis of breast cancer. In this study, the recent developments in electrochemical biosensors based on polymer nanocomposites and nanoparticles are reviewed, and the key performance characteristics, breast cancer biomarkers, and fabrication methods of biosensors are discussed. Future challenges and hindrances to the use of electrochemical biosensors in clinical practice are also explored.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Monu Kumar Shukla, Arpana Parihar, Chandrabose Karthikeyan, Deepak Kumar, Raju Khan
Summary: This review discusses the potential of multifunctional graphene quantum dots as a platform for receptor targeting, drug delivery, and bioimaging in pancreatic cancer. Multifunctional graphene quantum dots showed great promise as a versatile platform for the diagnosis and treatment of pancreatic cancer.
Review
Chemistry, Multidisciplinary
Monu Kumar Shukla, Arpana Parihar, Chandrabose Karthikeyan, Deepak Kumar, Raju Khan
Summary: This review discusses the potential of multifunctional graphene quantum dots (GQDs) as a platform for receptor targeting, drug delivery, and bioimaging in pancreatic cancer. GQDs have the ability to selectively target pancreatic cancer cells and serve as drug delivery vehicles for controlled and targeted release of therapeutics. Additionally, GQDs show promise as imaging agents for pancreatic cancer detection and monitoring.
Article
Biophysics
Ssu-Chia Chen, Kuan-Ting Chen, Amily Fang-Ju Jou
Summary: The novel dual-amplification-boosted electrochemical biosensor was developed for detecting pancreatic cancer-associated miR-196b, showing a detection limit of 0.26 pM and nice analytical reproducibility. The biosensor offers great promise as a complementary tool for real sample detection in the clinic.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Jianjian Zhuang, Haitao Wan, Xiaobo Zhang
Summary: A biosensor using AuNP-modified AuE and CPs was developed for the detection of miR-100 in GC patients' sera. The biosensor showed high specificity and sensitivity in distinguishing miR-100 variants, with a detection range from 100 aM to 10 pM and a LOD of 100 aM. The cutoff for gastric cancer detection was determined to be 5 fM based on testing 100 human sera samples.
Review
Nanoscience & Nanotechnology
Huanyu Yang, Renfa Liu, Yunxue Xu, Linxue Qian, Zhifei Dai
Summary: Current clinical studies review the use of photodynamic therapy with nanoparticles in treating pancreatic cancer. Nanoparticles have advantages in improving the efficacy of photodynamic therapy for pancreatic cancer treatment. Challenges and future outlook in developing nanoparticle-based photodynamic therapy for pancreatic cancer are discussed.
NANO-MICRO LETTERS
(2021)
Article
Chemistry, Analytical
Chunyu Zhang, Kai Zhang, Yanyan Cui, Yuecong Guo, Chuan Wang, Chao Xu, Qingqiang Yao, Yuliang Zhao, Chunying Chen, Yaling Wang
Summary: In this study, a multifunctional nanoprobe was designed to achieve three-dimensional localization of proteins in large, thick cells using synchrotron radiation hard X-ray imaging. The results showed that the HER2 protein was mainly distributed on the cell membrane with a heterogeneous pattern. This study provides a new method for non-destructive evaluation of the distribution of nanoprobes in cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Polymer Science
Selcan Karakus, Barbaros Akkurt, Elif Tuzun, Fatih Ozbas
Summary: In this study, green self-assembled two-dimensional bio-preservatives were prepared and characterized for their antibacterial and antifungal activities. The experimental results showed that these bio-preservatives exhibited excellent performance in preserving against pathogens.
Article
Chemistry, Physical
Maksat Islamkulov, Selcan Karakus, Cemal Ozeroglu
Summary: In this study, novel crosslinked hydrogels based on acrylamide-2-hydroxyethyl methacrylate and acrylamide-N-isopropylacrylamide were prepared and their swelling behavior was investigated. The effects of different experimental conditions on the swelling kinetics of the hydrogel networks were studied. The fabricated hydrogels showed great potential to be used as superabsorbents with high swelling ratios.
COLLOID AND POLYMER SCIENCE
(2023)
Article
Physics, Multidisciplinary
Mert Akin Insel, Selcan Karakus, Gizem Temelcan, Hale Gonce Kocken, Inci Albayrak
Summary: Fuzzy regression is used to predict the rheological properties of a bio-nanocomposite, and the fuzzy-hybrid model is found to outperform the crisp model in terms of accuracy and generality. This study highlights the impressive potential of the proposed models in nanotechnological manufacturing applications.
Article
Chemistry, Applied
Gizem Karabulut, Nuray Bekoz Ullen, Esin Akyuz, Selcan Karakus
Summary: SS316L is widely used in medical devices due to its biocompatibility, but bacterial adhesion and corrosion limit its usability in bioimplants. In this study, a protective coating of Locust Gum/polyethylene glycol-silver nanoparticles was successfully deposited on the SS316L surface, improving its antibacterial and anticorrosion properties.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Energy & Fuels
Nevin Tasaltin, Cihat Tasaltin, Fulya Ustun-Alkan, Selcan Karakus
Summary: In recent years, 2D nanomaterials have emerged as promising antimicrobial agents to combat antimicrobial resistance. This study focuses on the biological activity of silicene nanosheets and demonstrates their efficient antibacterial and antifungal activities against various pathogens. The unique morphology, structure, and stability of silicene nanosheets, along with their biocompatibility, suggest their potential for use in biomedical applications.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Chemistry, Analytical
Sana Jawaid, Sadam Hussain Tumrani, Ayman Nafady, Sirajuddin, Selcan Karakus, Mohammad Tabish, Nazeer Ahmed
Summary: In this study, an efficient screen-printed electrode platform was proposed for the selective detection of CD44 proteins. The platform utilized few-layered Ti3C2Tx nanosheets and hyaluronic acid (HA) for the specific recognition of CD44, allowing sensitive detection of CD44 proteins in the concentration range of 0.1 to 7.25 ng.mL(-1).
Article
Materials Science, Multidisciplinary
Nuray Bekoz Ullen, Gizem Karabulut, Selcan Karakus
Summary: This study focuses on the surface modification of 17-4 PH Stainless Steel Foam (SSF) with silver nanoparticles (Ag NPs) synthesized from various plant extracts. Versatile investigations were carried out to understand the effects of different matrix-based Ag NPs coatings on the surface characteristics of the porous structure. The results show that surface nanomodification has an impact on the structural and surface properties of SSF, and the coatings obtained from different plant extracts have different characteristics.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Construction & Building Technology
Ahmet Onur Pehlivan, Isil Sanri Karapinar, Selcan Karakus, Ayse Elif Ozsoy Ozbay, Ahmet Utku Yazgan
Summary: This study investigated the effects of using silver nanoparticles (Ag NPs) on the microstructure and mechanical properties of cementitious composites. Ag NPs were synthesized using a method involving konjac gum-polyethylene glycol (KG/PEG) and locust gum-polyethylene glycol (LG/PEG). The addition of Ag NPs significantly improved the compressive and flexural strengths of the nanocomposites.
JOURNAL OF MATERIALS IN CIVIL ENGINEERING
(2023)
Article
Chemistry, Applied
Selcan Karakus, Fatih Ozbas, Gulsen Baytemir, Nevin Tasaltin
Summary: This study focuses on the development of a smartphone-integrated biosensor using Corylus Colurna extract and Cu2O nanoparticles to detect ascorbic acid in food samples. The characterized biosensor exhibited high sensitivity and successfully detected ascorbic acid in food samples.
Article
Engineering, Environmental
Seda Melis Suren, Rumeysa Tutar, Cemal Ozeroglu, Selcan Karakus
Summary: This study successfully synthesizes a multi-network hydrogel using a novel combination of acrylamide and sodium vinyl sulfonate as monomers and N,N'-methylene bisacrylamide as a crosslinking agent, showing potential for wastewater treatment and drug delivery systems. The swelling behavior and paracetamol adsorption onto the hydrogel were also investigated. The results demonstrate that the hydrogel has considerable potential for the removal of paracetamol from aqueous solution, with the pseudo-second-order kinetic model offering an outstanding fit to the experimental data. This work contributes to the development of potential and sustainable materials for environmental and biomedical applications.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Materials Science, Multidisciplinary
Gizem Karabulut, Nuray Bekoz Ullen, Selcan Karakus, Ceyhun Toruntay
Summary: In order to improve the surface characteristics of 316L stainless steel, a coating using matcha/polyethylene glycol-CuO nanoparticles (Mat/PEG-CuO NPs) was applied. The coated stainless steel exhibited exceptional anti-corrosive and antibacterial properties, making it highly suitable for biomedical applications. The successful fabrication of spherical CuO nanoparticles coated onto SS316L holds great promise for future research and development in the field.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Analytical
Gul Naz, Mohamed A. Salem, Bharat Prasad Sharma, Saleh D. Mekkey, Razium Ali Soomro, Selcan Karakus, Zeinhom M. El-Bahy
Summary: A label-free electrochemical immunosensor based on MXene nanosheets and gold nanoparticles was developed for sensitive detection of the breast cancer biomarker CALR. The sensor showed excellent antifouling properties and high sensitivity in the low concentration range.
MICROCHEMICAL JOURNAL
(2023)
Article
Physics, Multidisciplinary
Dilber Esra Yildiz, Gulsen Baytemir, Nevin Tasaltin, Selcan Karakus, Gamze Gursu, Dursun Ali Kose
Summary: In this study, metal complexes of Leucine and Tryptophan were synthesized and used to fabricate nanocomposites. These nanocomposites were then utilized to fabricate non-enzymatic electrochemical sensors with high sensitivity for detecting dopamine, showing promising potential for biomedical applications.
Article
Engineering, Environmental
Sadam Hussain Tumrani, Rana R. Neiber, Zartasha Pitafi, Inas A. Ahmed, Razium Ali Soomro, Mohamed M. Ibrahim, Selcan Karakus, Zeinhom M. El-Bahy
Summary: In this study, we proposed an efficient electroactive platform for the direct electrochemical detection of clinically significant and emerging pharmaceutical pollutants. The platform consists of Pd nanocubes embedded within partially oxidized MXenes, which resulted in a highly compact and efficient architecture, facilitating enhanced charge transfer and electrocatalytic activity for the detection of nitrofurantoin.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Electrochemistry
Zaheer Abbas, Muhammad Ramzan Abdul Karim, Waseem Shehzad, Nemah Abu Shama, Jai Kumar, Sirajuddin, Selcan Karakus, Razium Ali Soomro, Ayman Nafady
Summary: This study demonstrates the utilization of polyaniline/multiwalled carbon nanotubes as a conductive scaffold for the formation of nickel manganese phosphate heterostructures, resulting in the development of an efficient hybrid super-capacitor. The optimized composite, PCNT-NMP-40, exhibits outstanding energy density and power density as a positive electrode in a two-electrode cell configuration.
ELECTROCHIMICA ACTA
(2023)
