Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies

SARS-CoV-2 infects cells following viral entry via clathrin-mediated endocytosis

(2021) Armin Bayati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation and Characterization of recombinant SARS-CoV-2 expressing reporter genes

(2021) Kevin Chiem et al.   JOURNAL OF VIROLOGY

Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase

(2021) Belén Martinez-Gualda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

COVID-19: breaking down a global health crisis

(2021) Saad I. Mallah et al.   Annals of Clinical Microbiology and Antimicrobials

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells

(2021) Jana Koch et al.   EMBO JOURNAL

Multiplex SARS-CoV-2 Genotyping Reverse Transcriptase PCR for Population-Level Variant Screening and Epidemiologic Surveillance

(2021) Hannah Wang et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

(2021) Maritza Puray-Chavez et al.   Cell Reports

Identification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV)

(2021) Sirle Saul et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of 4-Anilinoquinolines as Dengue Virus Inhibitors

(2021) Pei-Tzu Huang et al.   MOLECULES

Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients

(2021) Angélica Jayk Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

(2021) Dafydd R. Owen et al.   SCIENCE

Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines

(2020) Sirle Saul et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Rescue of SARS-CoV-2 from a Single Bacterial Artificial Chromosome

(2020) Chengjin Ye et al.   mBio

Sunitinib reduces the infection of SARS-CoV, MERS-CoV and SARS-CoV-2 partially by inhibiting AP2M1 phosphorylation

(2020) Pei-Gang Wang et al.   Cell Discovery

BIKE regulates dengue virus infection and is a cellular target for broad-spectrum antivirals

(2020) Szuyuan Pu et al.   ANTIVIRAL RESEARCH

Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

(2020) Andre C. Kalil et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

(2020) Steffen Klein et al.   Nature Communications

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

(2019) Christopher R. M. Asquith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma

(2019) Christopher R. M. Asquith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3-b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity

(2019) Sven Verdonck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioluminescence Profiling of NanoKAZ/NanoLuc Luciferase Using a Chemical Library of Coelenterazine Analogues

(2019) Eloi P Coutant et al.   CHEMISTRY-A EUROPEAN JOURNAL

Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

(2019) Maria L. Agostini et al.   JOURNAL OF VIROLOGY

Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment

(2018) Szu-Yuan Pu et al.   ANTIVIRAL RESEARCH

A Serine/Threonine Kinase 16-Based Phospho-Proteomics Screen Identifies WD Repeat Protein-1 As A Regulator Of Constitutive Secretion

(2018) Alfonso López-Coral et al.   Scientific Reports

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

(2017) Elena Bekerman et al.   JOURNAL OF CLINICAL INVESTIGATION

The target landscape of clinical kinase drugs

(2017) Susan Klaeger et al.   SCIENCE

Family-wide Structural Analysis of Human Numb-Associated Protein Kinases

(2016) Fiona J. Sorrell et al.   STRUCTURE

AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets

(2015) Gregory Neveu et al.   JOURNAL OF VIROLOGY

Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells

(2014) Julie G. In et al.   BIOCHEMICAL JOURNAL

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

(2012) James S. Duncan et al.   CELL

Identification and Selected Reaction Monitoring (SRM) Quantification of Endocytosis Factors Associated with Numb

(2012) Jonathan R. Krieger et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly

(2012) Gregory Neveu et al.   PLoS Pathogens

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

GAK, a regulator of clathrin-mediated membrane trafficking, localizes not only in the cytoplasm but also in the nucleus

(2009) Jun Sato et al.   GENES TO CELLS

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

AAK1 Regulates Numb Function at an Early Step in Clathrin-Mediated Endocytosis

(2008) Erika B. Sorensen et al.   TRAFFIC