Review
Public, Environmental & Occupational Health
D. Buonsenso, G. Salerno, G. Sodero, F. Mariani, L. Pisapia, C. Gelormini, M. Di Nardo, P. Valentini, G. Scoppettuolo, D. G. Biasucci
Summary: This study evaluated the treatment strategies for central venous catheter-related bloodstream infections in pediatric patients. The findings suggest that adding an antimicrobial lock solution to systemic antibiotics may be beneficial for successful catheter salvage in children with CRBSI, but no significant difference was found in CLABSI cases between the addition of an antimicrobial lock solution and systemic antibiotic alone.
JOURNAL OF HOSPITAL INFECTION
(2022)
Review
Infectious Diseases
Rafael San-Juan, Maria Ruiz-Ruigomez, Jose Maria Aguado
Summary: The incidence of GNB-CRBSI has been increasing in recent years, posing a challenge due to high rates of multidrug resistance. There are no specific guidelines for its management and optimal treatment duration has not been clearly defined. Recent studies show that complications risk differs from that of Staphylococcus aureus. Therefore, a short course of antibiotics after CVC removal may be effective, while monitoring complications through blood cultures or echocardiography seems less helpful.
CURRENT OPINION IN INFECTIOUS DISEASES
(2022)
Article
Pediatrics
William J. H. Ford, David G. Bundy, Suzette Oyeku, Moonseong Heo, Lisa Saiman, Rebecca E. Rosenberg, Patricia DeLaMora, Barbara Rabin, Philip Zachariah, Parsa Mirhaji, Elizabeth Klein, Oghale Obaro-Best, Michael Drasher, Alexandre Peshansky, Michael L. Rinke
Summary: This study evaluated the salvage of CVC in pediatric patients with ambulatory CLABSI and associated risk factors for treatment failure. The results showed that CVC salvage was frequently attempted and was successful in many cases, with specific factors such as underlying diagnosis, CVC type, and absence of candidemia being associated with attempted and successful salvage.
Review
Nutrition & Dietetics
Michelle Gompelman, Carmen Paus, Ashley Bond, Reinier P. Akkermans, Chantal P. Bleeker-Rovers, Simon Lal, Geert J. A. Wanten
Summary: The study found that in patients on home parenteral nutrition (HPN), the addition of an antimicrobial lock solution was more beneficial for successful catheter salvage compared to systemic antibiotics alone. Recurrence rates were lower in studies using antimicrobial lock therapy (ALP) compared to those using systemic antibiotics alone.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Public, Environmental & Occupational Health
C. H. van den Bosch, B. Jeremiasse, J. T. van der Bruggen, F. N. J. Frakking, Y. G. T. Loeffen, C. P. van de Ven, A. F. W. van der Steeg, M. F. Fiocco, M. D. van de Wetering, M. H. W. A. Wijnen
Summary: This study aimed to evaluate the efficacy of taurolidine-containing lock solutions (TL) compared to other lock solutions in preventing central venous catheter (CVC)-related bloodstream infections. The results showed that TL might be a promising method for preventing CVC-related bloodstream infections, but larger randomized controlled trials are needed for more conclusive evidence.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Nanoscience & Nanotechnology
Rajnish Kumar, Hamed Massoumi, Manjyot Kaur Chug, Elizabeth J. Brisbois
Summary: Antimicrobial-lock therapy is an economically viable strategy to prevent catheter-related bloodstream infections. SNACET lock solution shows promising potential in reducing bacterial adhesion and inhibiting catheter-related infections through its tunable nitric oxide release capability.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Microbiology
Daria V. Vasina, Nataliia P. Antonova, Igor Grigoriev, Victoria S. Yakimakha, Anastasiya M. Lendel, Maria A. Nikiforova, Andrei A. Pochtovyi, Timofey A. Remizov, Evgeny Usachev, Natalia Shevlyagina, Vladimir G. Zhukhovitsky, Mikhail Fursov, Vasiliy D. Potapov, Aleksei M. Vorobev, Andrey Aleshkin, Aleksei Laishevtsev, Valentine V. Makarov, Sergey M. Yudin, Artem P. Tkachuk, Vladimir A. Gushchin
Summary: Endolysin-based therapeutics show promise as antibacterial agents, especially against Gram-negative pathogens. This study comprehensively investigated four Gram-negative bacteria-targeting endolysins for their antimicrobial efficacy, activity, and biological safety, demonstrating broad spectrum effectiveness with minimal safety concerns.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Critical Care Medicine
Scott Mayer, Colin Bonhag, Patrick Jenkins, Brendon Cornett, Paula Watts, Dmitriy Scherbak
Summary: This retrospective observational cohort study found that the administration of probiotics to ICU patients with central venous catheters is associated with a substantial rate of probiotic-associated bloodstream infections, leading to increased mortality. Powder formulations of probiotics have a higher rate of infection compared to nonpowder formulations.
CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Andrew Bock, Blake M. Hanson, Felicia Ruffin, Joshua B. Parsons, Lawrence P. Park, Batu Sharma-Kuinkel, Michael Mohnasky, Cesar A. Arias, Vance G. Fowler, Joshua T. Thaden
Summary: Recurrent gram-negative bacterial bloodstream infections (GNB-BSI) are mainly caused by relapse, and pulsed-field gel electrophoresis accurately differentiates relapse from reinfection. Having a cardiac device is a risk factor for relapse.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Arsheena Yassin, Mariya Huralska, Jason M. Pogue, Deepali Dixit, Robert G. Sawyer, Keith S. Kaye
Summary: The prevalence of multidrug-resistant gram-negative bacterial infections has significantly increased in the past decade, leading to higher rates of morbidity and mortality. Treating these infections presents challenges, particularly for critically ill patients with limited margin for error. The availability of new therapies has improved treatment options, but optimal clinical and therapeutic approaches for managing these infections still need to be established.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Claire M. Rickard, Nicole M. Marsh, Emily N. Larsen, Matthew R. McGrail, Nicholas Graves, Naomi Runnegar, Joan Webster, Amanda Corley, David McMillan, John R. Gowardman, Debbie A. Long, John F. Fraser, Fenella J. Gill, Jeanine Young, Marghie Murgo, Evan Alexandrou, Md Abu Choudhury, Raymond J. Chan, Nicole C. Gavin, Azlina Daud, Annamaria Palermo, Adrian Regli, E. Geoffrey Playford
Summary: This study compared the effectiveness and costs of 7-day versus 4-day infusion set replacement to prevent CRBSI in patients with central venous access devices and peripheral arterial catheters. It found that extending infusion set use to 7 days can reduce costs and workload safely in both types of catheters.
Article
Urology & Nephrology
Sonja van Roeden, Mathijs van Oevelen, Alferso C. Abrahams, Friedo W. Dekker, Joris Rotmans, Sabine C. A. Meijvis
Summary: Taurolidine-based lock solutions were associated with a significantly lower hazard for removal of CVC due to infection or malfunction combined, compared to citrate-based lock solutions. High-concentrated citrate lock solutions did not show a decreased hazard for these outcomes compared to low-concentrated citrate lock solutions.
Article
Biochemistry & Molecular Biology
Yunliang Zang, Eve Marder, Shimon Marom
Summary: Important Na+ channels responsible for action potentials undergo rapid inactivation while the membrane potential remains depolarized. This rapid inactivation plays a role in millisecond-scale phenomena and affects spike shape and refractory periods. In addition, they also undergo much slower inactivation that has longer-term impacts on excitability. This study focuses on the contribution of slow inactivation to axonal excitability and shows that it is crucial for achieving proper axonal propagation.
Article
Biotechnology & Applied Microbiology
M. David Mansouri, Venkat Ramanthan, Dena L. Mansouri, Richard A. Hull
Summary: This study demonstrates that NACLEV-CLS can significantly reduce bacterial colonization and potentially salvage infected catheters without affecting the catheter's mechanical integrity. The SEM images also show a reduction in colonization with NACLEV-CLS, indicating a promising broad spectrum of antimicrobial activity against catheter-associated infections.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dajana Lendak, Pedro Puerta-Alcalde, Estela Moreno-Garcia, Mariana Chumbita, Nicole Garcia-Pouton, Celia Cardozo, Laura Morata, Maria Suarez-Lledo, Marta Hernandez-Meneses, Lucio Ghiglione, Francesc Marco, Jose Antonio Martinez, Josep Mensa, Ivana Urosevic, Alex Soriano, Carolina Garcia-Vidal
Summary: The study found a significant shift in the epidemiology of CRBSIs in onco-hematological neutropenic patients, with an increase in Gram-negative bacilli infections and multidrug-resistant cases. Independent factors associated with GNB-CRBSIs include longer duration of catheter placement, older age, and prior use of penicillins. Additionally, inappropriate empirical antibiotic treatments led to an increase in mortality rates over time.
Article
Chemistry, Applied
Hasan Sahin, Aynur Sari, Nurten Ozsoy, Berna Ozbek Celik, Onur Koyuncu
NATURAL PRODUCT RESEARCH
(2020)
Article
Biotechnology & Applied Microbiology
Emel Mataraci Kara, Nilufer Bayrak, Hatice Yildirim, Mahmut Yildiz, Berna Ozbek Celik, Amac Fatih Tuyun
FOLIA MICROBIOLOGICA
(2020)
Article
Oncology
Emel Mataraci Kara, Mesut Yilmaz, Ayse Istanbullu Tosun, Berna Ozbek Celik
JOURNAL OF CHEMOTHERAPY
(2020)
Article
Infectious Diseases
Emel Mataraci Kara, Mesut Yilmaz, Ayse Istanbullu Tosun, Berna Ozbek Celik
INFECTIOUS DISEASES
(2020)
Article
Microbiology
Emel Mataraci-Kara, Mesut Yilmaz, Berna Ozbek-Celik
CURRENT MICROBIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Ozlen Guzel-Akdemir, Muhammed Trawally, Mehtap Ozbek-Babuc, Berna Ozbek-Celik, Gorkem Ermut, Hakan Ozdemir
MONATSHEFTE FUR CHEMIE
(2020)
Article
Infectious Diseases
Damla Damar-Celik, Niels Norskov-Lauritsen, Berna Ozbek-Celik
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2020)
Article
Chemistry, Medicinal
Emel Mataraci-Kara, Nilufer Bayrak, Mahmut Yildiz, Hatice Yildirim, Berna Ozbek-Celik, Amac Fatih Tuyun
Summary: Novel quinolinequinones exhibit promising antibacterial and antifungal activities, particularly showing higher efficacy in inhibiting biofilm attachment processes. These compounds have potential as lead candidates for clinical applications in treating serious infections as treatment options against antibiotic-resistant bacteria are becoming more limited.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Medicine, Research & Experimental
Meryem Ozdemir, Sevda Suzgec-Selcuk, Emel Mataraci-Kara, Berna Ozbek-Celik
Summary: The study aimed to compare Matricaria chamomilla samples from different sources, conduct quality control analyses, and investigate their antimicrobial activities. Results showed true chamomile samples among herbalist samples, while pharmacy samples were qualified but limited in variety. Essential oil analysis highlighted the influence of geographical location on natural samples. Antimicrobial activity tests did not yield significant results.
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
(2021)
Article
Oncology
Bekir Ozer, Berna Ozbek Celik
Summary: This study assessed the bactericidal activities of Eravacycline alone or in combination with Colistin, Meropenem, or Ceftazidime against 50 Achromobacter spp. strains. The study found that Meropenem alone was the most effective antibiotic, and Eravacycline-Colistin combinations showed bactericidal and synergistic activities against certain strains.
JOURNAL OF CHEMOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Hatice Yildirim, Mahmut Yildiz, Nilufer Bayrak, Emel Mataraci-Kara, Berna Ozbek-Celik, Masami Otsuka, Mikako Fujita, Mohamed O. Radwan, Amac Fatih TuYuN
Summary: Thiolated CoQ analogs were designed, synthesized, and characterized for their antimicrobial properties. CoQ1 and CoQ2 showed promising antibacterial activity against Gram-positive bacteria and potential molecular interactions with S. aureus DNA gyrase.
Article
Chemistry, Physical
Nilufer Bayrak, Mahmut Yildiz, Hatice Yildirim, Emel Mataraci Kara, Berna Ozbek Celik, Amac Fatih Tuyun
JOURNAL OF MOLECULAR STRUCTURE
(2020)
Article
Pharmacology & Pharmacy
Turgut Taskin, Tugba Gezmis, Muhammet Emin Cam, Duygu Taskin, Berna Ozbek Celik, Ismail Senkardes, Sevda Suzgec-Selcuk
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Chemistry, Medicinal
Turgut Taskin, Yeliz Akkilic, Berna Ozbek Celik, Ismail Senkardes, Ozlem B. Ozakpinar
NATURAL PRODUCTS JOURNAL
(2020)
Article
Infectious Diseases
Berna Ozbek-Celik, Damla Damar-Celik, Emel Mataraci-Kara, Cagla Bozkurt-Guzel, Paul B. Savage
