Lipid microbubbles as a vehicle for targeted drug delivery using focused ultrasound-induced blood–brain barrier opening

Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood–brain barrier opening and brain-tumor drug delivery

(2015) Ching-Hsiang Fan et al.   Acta Biomaterialia

Applying the Retro-Enantio Approach To Obtain a Peptide Capable of Overcoming the Blood-Brain Barrier

(2015) Roger Prades et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced Delivery and Bioactivity of the Neurturin Neurotrophic Factor through Focused Ultrasound—Mediated Blood—Brain Barrier Opening in vivo

(2015) Gesthimani Samiotaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of the microbubble shell physicochemical properties on ultrasound-mediated drug delivery to the brain

(2015) Shih-Ying Wu et al.   JOURNAL OF CONTROLLED RELEASE

Acoustic cavitation-based monitoring of the reversibility and permeability of ultrasound-induced blood-brain barrier opening

(2015) Tao Sun et al.   PHYSICS IN MEDICINE AND BIOLOGY

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

(2015) Gerhard Leinenga et al.   Science Translational Medicine

Ultrasound and Microbubble-Induced Local Delivery of MicroRNA-Based Therapeutics

(2015) Rick F.J. Kwekkeboom et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Long-Term Safety of Repeated Blood-Brain Barrier Opening via Focused Ultrasound with Microbubbles in Non-Human Primates Performing a Cognitive Task

(2015) Matthew E. Downs et al.   PLoS One

Noninvasive, neuron-specific gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated virus

(2014) S Wang et al.   GENE THERAPY

Transcranial cavitation detection in primates during blood-brain barrier opening-a performance assessment study

(2014) Shih-Ying Wu et al.   IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure

(2014) Hong Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Prolonged survival upon ultrasound-enhanced doxorubicin delivery in two syngenic glioblastoma mouse models

(2014) Zsofia Kovacs et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Delivery of Erythropoietin by Transcranial Focused Ultrasound for Neuroprotection against Ischemia/Reperfusion-Induced Neuronal Injury: A Long-Term and Short-Term Study

(2014) Sheng-Kai Wu et al.   PLoS One

Real-Time, Transcranial Monitoring of Safe Blood-Brain Barrier Opening in Non-Human Primates

(2014) Fabrice Marquet et al.   PLoS One

A New Brain Drug Delivery Strategy: Focused Ultrasound-Enhanced Intranasal Drug Delivery

(2014) Hong Chen et al.   PLoS One

Noninvasive and Targeted Drug Delivery to the Brain Using Focused Ultrasound

(2013) Alison Burgess et al.   ACS Chemical Neuroscience

Focused Ultrasound Delivers Targeted Immune Cells to Metastatic Brain Tumors

(2013) R. Alkins et al.   CANCER RESEARCH

Dependence of the reversibility of focused- ultrasound-induced blood-brain barrier opening on pressure and pulse length in vivo

(2013) Gesthimani Samiotaki et al.   IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

An experimental study on the stiffness of size-isolated microbubbles using atomic force microscopy

(2013) Cherry C. Chen et al.   IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets

(2013) Cherry C. Chen et al.   JOURNAL OF CONTROLLED RELEASE

Noninvasive and Transient Blood-Brain Barrier Opening in the Hippocampus of Alzheimer's Double Transgenic Mice Using Focused Ultrasound

(2013) James J. Choi et al.   ULTRASONIC IMAGING

Microbubble Type and Distribution Dependence of Focused Ultrasound-Induced Blood–Brain Barrier Opening

(2013) Shutao Wang et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Temporary Disruption of the Blood-Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

(2012) N. McDannold et al.   CANCER RESEARCH

Ultrasound-Induced Blood-Brain Barrier Opening

(2012) Elisa E. Konofagou et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression

(2012) Alison Burgess et al.   JOURNAL OF CONTROLLED RELEASE

Ultrasound-mediated blood‐brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model

(2012) Eun-Joo Park et al.   JOURNAL OF CONTROLLED RELEASE

Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood–brain barrier using focused ultrasound and microbubbles

(2012) Babak Baseri et al.   PHYSICS IN MEDICINE AND BIOLOGY

Blood-Brain Barrier: Real-time Feedback-controlled Focused Ultrasound Disruption by Using an Acoustic Emissions–based Controller

(2012) Meaghan A. O’Reilly et al.   RADIOLOGY

Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates

(2011) Fabrice Marquet et al.   APPLIED PHYSICS LETTERS

Concurrent blood–brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment

(2011) Chien-Yu Ting et al.   BIOMATERIALS

Targeted gene delivery to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption

(2011) Qin Huang et al.   EXPERIMENTAL NEUROLOGY

Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation

(2011) Linsey C. Phillips et al.   JOURNAL OF CONTROLLED RELEASE

The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice

(2011) Yao-Sheng Tung et al.   JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA

Permeability dependence study of the focused ultrasound-induced blood-brain barrier opening at distinct pressures and microbubble diameters using DCE-MRI

(2011) Fotios Vlachos et al.   MAGNETIC RESONANCE IN MEDICINE

A quantitative pressure and microbubble-size dependence study of focused ultrasound-induced blood-brain barrier opening reversibility in vivo using MRI

(2011) Gesthimani Samiotaki et al.   MAGNETIC RESONANCE IN MEDICINE

Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice

(2011) Alexandra Petiet et al.   NEUROBIOLOGY OF AGING

Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles

(2011) J. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A PVDF Receiver for Ultrasound Monitoring of Transcranial Focused Ultrasound Therapy

(2010) Meaghan A Oreilly et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Noninvasive and Localized Blood—Brain Barrier Disruption using Focused Ultrasound can be Achieved at Short Pulse Lengths and Low Pulse Repetition Frequencies

(2010) James J Choi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Permeability assessment of the focused ultrasound-induced blood–brain barrier opening using dynamic contrast-enhanced MRI

(2010) F Vlachos et al.   PHYSICS IN MEDICINE AND BIOLOGY

In vivotranscranial cavitation threshold detection during ultrasound-induced blood–brain barrier opening in mice

(2010) Yao-Sheng Tung et al.   PHYSICS IN MEDICINE AND BIOLOGY

Microbubble-Size Dependence of Focused Ultrasound-Induced Blood–Brain Barrier Opening in Mice In Vivo

(2009) J.J. Choi et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

(2009) Reinhard Gabathuler   NEUROBIOLOGY OF DISEASE

Microbubble size isolation by differential centrifugation

(2008) Jameel A. Feshitan et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Hemorrhage Detection During Focused-Ultrasound Induced Blood-Brain-Barrier Opening by Using Susceptibility-Weighted Magnetic Resonance Imaging

(2008) Hao-Li Liu et al.   ULTRASOUND IN MEDICINE AND BIOLOGY