Article
Chemistry, Multidisciplinary
Sophie Morse, Aishwarya Mishra, Tiffany G. Chan, Rafael T. M. de Rosales, James J. Choi
Summary: The study investigates a noninvasive method of using ultrasound pulses to deliver liposomes across the blood-brain barrier for efficient drug delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Oliver Vince, Sarah Peeters, Vanessa A. Johanssen, Michael Gray, Sean Smart, Nicola R. Sibson, Eleanor Stride
Summary: The study shows that a new formulation of microbubbles containing lysolipids can enhance blood-brain barrier permeability, leading to approximately twofold increase at the highest ultrasound pressure. This modification has the potential to improve drug delivery deep within the brain without the need to increase ultrasound pressure amplitude.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Biomedical
Paul Mondou, Sebastien Meriaux, Florent Nageotte, Jonathan Vappou, Anthony Novell, Benoit Larrat
Summary: This review summarizes the current state of in vitro and in vivo cavitation control algorithms for blood-brain barrier (BBB) permeabilization using microbubbles (MB) and focused ultrasound (FUS). It describes the different cavitation states, the indexes used for ultrasonic monitoring, and the various control strategies for BBB permeabilization.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Scott Schoen, M. Sait Kilinc, Hohyun Lee, Yutong Guo, F. Levent Degertekin, Graeme F. Woodworth, Costas Arvanitis
Summary: Brain tumors located in the central nervous system (CNS) present a unique challenge due to limited drug access to the brain tumor microenvironment (TME). Recent advancements in microbubble ultrasound contrast agents and ultrasound energy have shown promise in enhancing drug delivery to brain tumors. This technology has the potential to improve the effectiveness of both traditional chemotherapy and novel immunotherapeutic agents. Early clinical studies have demonstrated safety, and ongoing Phase I/II trials are testing the preclinical findings.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Anshuman Dasgupta, Tao Sun, Elena Rama, Alessandro Motta, Yongzhi Zhang, Chanikarn Power, Diana Moeckel, Stecia-Marie Fletcher, Mirjavad Moosavifar, Roman Barmin, Celine Porte, Eva Miriam Buhl, Celine Bastard, Roger M. Pallares, Fabian Kiessling, Nathan Mcdannold, Samir Mitragotri, Twan Lammers
Summary: This study demonstrates the design and application of a novel microbubble (MB) system that can better penetrate the blood-brain barrier (BBB) and deliver drugs effectively by altering the shape and surface modification. In vitro and in vivo experiments show that rod-shaped MBs efficiently bind to BBB endothelium and generate stronger cavitation effects compared to traditional spherical MBs, resulting in enhanced drug delivery.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Dallan McMahon, Lulu Deng, Kullervo Hynynen
Summary: The study compared the safety and efficacy of drug delivery to the brain using 10 ms tone bursts and rapid short-pulse (RaSP) sequence with transcranial focused ultrasound and microbubble exposure. The RaSP sequence did not show measurable improvements over the B10 sequence in terms of blood-brain barrier permeability enhancement for drug delivery, and may present an increased risk of vascular damage.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Ko-Ting Chen, Kuo-Chen Wei, Hao-Li Liu
Summary: Focused ultrasound combined with microbubbles enables precise, transient, reversible, and noninvasive opening of the blood-brain barrier. This technology enhances the penetration of therapeutic agents in the central nervous system, while also modulating local immunity and neuronal activity.
Article
Multidisciplinary Sciences
Pavlos Anastasiadis, Dheeraj Gandhi, Yutong Guo, Abdul-Kareem Ahmed, Soren M. Bentzen, Costas Arvanitis, Graeme F. Woodworth
Summary: This study evaluates the safety and utility of microbubble-enhanced focused ultrasound for spatially targeted blood-brain barrier opening in patients with infiltrating gliomas.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Yuanyuan Shen, Mengni Hu, Wen Li, Yiling Chen, Yiluo Xu, Litao Sun, Dongzhe Liu, Siping Chen, Yueqing Gu, Yi Ma, Xin Chen
Summary: This study demonstrates the potential of using focused ultrasound combined with microbubbles (FUS/MB) to deliver DNA nanostructures as drug carriers for glioma therapy. The FUS/MB treatment successfully opened the blood-brain barrier (BBB) in a localized region, allowing for increased drug concentration in the glioma and improved therapeutic efficiency. The findings suggest that FUS/MB could serve as an alternative strategy for delivering anticancer drugs to the brain.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Robin Ji, Maria E. Karakatsani, Mark Burgess, Morgan Smith, Maria F. Murillo, Elisa E. Konofagou
Summary: This study found significant changes in the relative gene expression of inflammatory cytokines and receptors in different cavitation dose groups at 6 and 24 hours after FUS-induced BBB opening. The degree of changes in relative expression levels and the number of genes with significant changes increased with higher cavitation dose. By 72 hours post-opening, gene expression levels returned to baseline in all cavitation dose groups.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Medicine, Research & Experimental
Alexander S. Mathew, Catherine M. Gorick, Richard J. Price
Summary: Focused ultrasound (FUS) blood brain barrier disruption (BBBD) can enhance immunotherapies, clear proteins, and promote neurogenesis as secondary effects. By analyzing 75 murine transcriptomes in a multiple regression framework, researchers found that mechanical and biochemical stimuli associated with FUS BBBD can predict gene expression in the brain, offering potential for tuning secondary effects by modulating FUS parameters.
Review
Pharmacology & Pharmacy
Charlotte Berard, Charles Truillet, Benoit Larrat, Frederic Dhermain, Marie-Anne Esteve, Florian Correard, Anthony Novell
Summary: The therapeutic management of gliomas is a difficult task due to the challenges presented by brain tumors, including the presence of blood-brain barriers that prevent effective drug delivery. Focused ultrasound-mediated BBB disruption offers a promising non-invasive method to enhance drug delivery into brain tumors. Clinical trials and preclinical studies have demonstrated the potential of this approach in glioma therapy. However, there are still challenges to overcome for its clinical use.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Jinghan Zhang, Fei Yan, Wei Zhang, Lei He, Yi Li, Shuai Zheng, Yuanyuan Wang, Tengfei Yu, Lijuan Du, Yuanyuan Shen, Wen He
Summary: This study suggests that biosynthetic GVs have great potential to serve as local BBB-opening agents for targeted drug delivery in the development of new strategies for central nervous system disorders.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yu-Hone Hsu, Wei-Chung Lee, Shing-Shung Chu, Meng-En Chao, Kuo-Sheng Wu, Ren-Shyan Liu, Tai-Tong Wong
Summary: Pulsed ultrasound combined with microbubbles can temporarily disrupt the blood-brain barrier (BBB) and open a temporal window for delivering large therapeutic molecules into brain tissue. This study investigates the effects of different sonication parameters, time, and microbubble dose on BBB disruption, as well as the dynamics of BBB disruption and the efficacy of different sonication schemes. The results show that pulsed weakly focused ultrasound can extensively and reversibly open the BBB with limited brain tissue damage.
Review
Engineering, Biomedical
Dallan McMahon, Meaghan A. O'Reilly, Kullervo Hynynen
Summary: This article discusses the application of using focused ultrasound and microbubbles to increase cerebrovascular permeability for drug delivery, includes technical and biological considerations, summarizes results from clinical trials, and discusses the future direction of the field.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021
(2021)
Article
Acoustics
Antonios N. Pouliopoulos, Cameron A. B. Smith, James H. Bezer, Ahmed El Ghamrawy, Krit Sujarittam, Charlotte J. Bouldin, Sophie V. Morse, Meng-Xing Tang, James J. Choi
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2020)
Article
Acoustics
Harry J. Davies, Sophie Morse, Matthew J. Copping, Krit Sujarittam, Victor D. Bourgin, Meng-Xing Tang, James J. Choi
Summary: Passive acoustic mapping (PAM) is an algorithm that reconstructs the location of acoustic sources using an array of receivers. The ATP-PAM algorithm described in this article utilizes time of flight and delay-and-sum beamforming to locate acoustic sources in both the lateral and axial dimensions, vastly improving spatial resolution. This approach has been shown to be effective in targeting and monitoring drug delivery into the brain.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Acoustics
James H. Bezer, Hasan Koruk, Christopher J. Rowlands, James J. Choi
ULTRASOUND IN MEDICINE AND BIOLOGY
(2020)
Article
Acoustics
Zheng Jiang, Robert J. Dickinson, Timothy L. Hall, James J. Choi
Summary: The design of stacked transducer allows for transmission and reception of short-pulse ultrasound from the same location, improving the effectiveness of therapeutic ultrasound technologies.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Acoustics
Zheng Jiang, Krit Sujarittam, Betul Ilbilgi Yildiz, Robert J. Dickinson, James J. Choi
Summary: Therapeutic ultrasound and microbubble technologies aim to safely manipulate tissue or release drugs by controlling microbubble activity. However, current sensor systems introduce distortions to the acoustic signal. This study developed a sensor array with small, broadband sensors and a low-phase distorting material to accurately monitor and localize microbubble activities, potentially advancing better feedback control methods and safer and more effective treatments.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Chemistry, Multidisciplinary
Sophie Morse, Aishwarya Mishra, Tiffany G. Chan, Rafael T. M. de Rosales, James J. Choi
Summary: The study investigates a noninvasive method of using ultrasound pulses to deliver liposomes across the blood-brain barrier for efficient drug delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Richard Perryman, Alexander Renziehausen, Hamidreza Shaye, Androniki D. Kostagianni, Antonis D. Tsiailanis, Thomas Thorne, Maria Chatziathanasiadou, Gregory B. Sivolapenko, Mohamed Ahmed El Mubarak, Gye Won Han, Barbara Zarzycka, Vsevolod Katritch, Guillaume Lebon, Cristiana Lo Nigro, Laura Lattanzio, Sophie Morse, James J. Choi, Kevin O'Neill, Zoi Kanaki, Apostolos Klinakis, Tim Crook, Vadim Cherezov, Andreas G. Tzakos, Nelofer Syed
Summary: This study reveals that AT(2)R is a therapeutic target for GBM and AngII promotes proliferation through this receptor. EMA401 and its derivative A3E can inhibit the proliferation and invasiveness of GBM, and show enhanced penetration in the CNS.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Shusei Kawara, Brian Cunningham, James Bezer, K. C. Neelima, Jingwen Zhu, Meng-Xing Tang, Jun Ishihara, James J. Choi, Sam H. Au
Summary: This study presents a method for selectively controlling interactions between wires, hydrogels, and world-to-chip interfaces. The wire templating method enables the fabrication of perfusable hydrogel-based capillary-scale networks with diameters as small as 6.1 microns. This technique has the potential to improve experimental models of capillary networks for studying human health and disease.
Meeting Abstract
Oncology
Richard Perryman, Alexander Renziehausen, Hamidreza Shaye, Androniki Kostagianni, Antonis Tsiailanis, Tom Thorne, Maria Chatziathanasiadou, Gregory Sivolapenko, Mohamed Ahmed El Mubarak, Gye Won Han, Barbara Zarzycka, Vsevolod Katritch, Guillaume Lebon, Cristiana Lo Nigro, Laura Lattanzio, Sophie Morse, James Choi, Kevin O'Neill, Zoe Kanaki, Apostolos Klinakis, Tim Crook, Vadim Cherezov, Andreas Tzakos, Nelofer Syed
Meeting Abstract
Oncology
Dani Chattenton, Ian Rivens, Zheng Jiang, Diana M. Carvalho, Krit Sujarittam, Jessica K. R. Boult, Simon P. Robinson, Chris Jones, Gail ter Haar, James Choi
Article
Acoustics
Krit Sujarittam, James J. Choi
Summary: This letter examines the relationship between bubble concentration and the energy ratio of low to high frequency bands of their acoustic emissions. The study utilizes two sensors, perpendicular and concentric to a transmitter, to capture the emissions from sonicated microbubbles. The findings reveal that emissions from different bubbles reach the perpendicular sensor with small time differences, leading to constructive and destructive interference between low and high frequencies. The energy ratio of low-frequency (2nd-3rd harmonics) to high-frequency (7th-12th harmonics) increases with bubble concentration, but this relationship is not observed with the concentric sensor due to larger time differences.
JASA EXPRESS LETTERS
(2022)
Proceedings Paper
Acoustics
Eleanor Martin, Andrew Hurrell, James Choi, Bradley Treeby
Summary: The study demonstrated that conducting ultrasound pulse experiments and numerical evaluations within ex vivo human skull using large aperture focused ultrasound transducers and short pulse lengths can facilitate targeted BBB opening.
INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS 2021)
(2021)
Article
Chemistry, Multidisciplinary
Tiffany G. Chan, Carmen L. Ruehl, Sophie V. Morse, Michelle Simon, Viktoria Rakers, Helena Watts, Francesco A. Aprile, James J. Choi, Ramon Vilar
Summary: New metal complexes have been found to inhibit amyloid-beta aggregation with high activity and non-cytotoxicity, and can be safely delivered across the blood-brain barrier to specific locations in the brains of mice using focused ultrasound.
Article
Acoustics
Krit Sujarittam, James J. Choi
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2020)
Article
Medicine, Research & Experimental
Sophie Morse, Tamara Boltersdorf, Bethany Harriss, Tiffany G. Chan, Nicoleta Baxan, Hee Seok Jung, Antonios N. Pouliopoulos, James J. Choi, Nicholas J. Long