Obesity and stroke: Can we translate from rodents to patients?

Collider Bias Is Only a Partial Explanation for the Obesity Paradox

(2016) Matthew Sperrin et al.   EPIDEMIOLOGY

The blood–brain barrier after stroke: Structural studies and the role of transcytotic vesicles

(2016) Michael J Haley et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Obese Japanese Patients with Stroke Have Higher Functional Recovery in Convalescent Rehabilitation Wards: A Retrospective Cohort Study

(2016) Shinta Nishioka et al.   Journal of Stroke & Cerebrovascular Diseases

Strain-Related Differences in the Immune Response: Relevance to Human Stroke

(2016) Kyra J. Becker   Translational Stroke Research

Obese Japanese Patients with Stroke Have Higher Functional Recovery in Convalescent Rehabilitation Wards: A Retrospective Cohort Study

(2016) Shinta Nishioka et al.   Journal of Stroke & Cerebrovascular Diseases

Does selection bias explain the obesity paradox among individuals with cardiovascular disease?

(2015) Hailey R. Banack et al.   ANNALS OF EPIDEMIOLOGY

Obesity Paradox versus Frailty Syndrome in First-Ever Ischemic Stroke Survivors

(2015) Seyyed Mohammad Reza Kazemi-Bajestani et al.   International Journal of Stroke

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke

(2015) Samaneh Maysami et al.   Journal of Neuroinflammation

The Obesity Paradox and Survivors of Ischemic Stroke

(2015) Peter Wohlfahrt et al.   Journal of Stroke & Cerebrovascular Diseases

The Obesity Paradox in Stroke: Impact on Mortality and Short-term Readmission

(2015) Raquel Barba et al.   Journal of Stroke & Cerebrovascular Diseases

Metabolic Syndrome Predicts Refractoriness to Intravenous Thrombolysis in Acute Ischemic Stroke

(2015) Laura Dorado et al.   Journal of Stroke & Cerebrovascular Diseases

Obesity Exacerbates Rat Cerebral Ischemic Injury through Enhancing Ischemic Adiponectin-Containing Neuronal Apoptosis

(2015) Ming-Hsiu Wu et al.   MOLECULAR NEUROBIOLOGY

Obesity Paradox in the Course of Cerebrovascular Diseases

(2015) Anna Brzecka et al.   Advances in Clinical and Experimental Medicine

Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion rats

(2015) Xiao-Lu Cao et al.   EXPERIMENTAL BRAIN RESEARCH

The Obesity Paradox and Survivors of Ischemic Stroke

(2015) Peter Wohlfahrt et al.   Journal of Stroke & Cerebrovascular Diseases

The Obesity Paradox in Stroke: Impact on Mortality and Short-term Readmission

(2015) Raquel Barba et al.   Journal of Stroke & Cerebrovascular Diseases

Metabolic Syndrome Predicts Refractoriness to Intravenous Thrombolysis in Acute Ischemic Stroke

(2015) Laura Dorado et al.   Journal of Stroke & Cerebrovascular Diseases

The Impact of Body Weight on Mortality After Stroke

(2015) Wolfram Doehner et al.   JAMA Neurology

Adipocytokines, C-Reactive Protein, and Cardiovascular Disease: A Population-Based Prospective Study

(2015) Ekim Seven et al.   PLoS One

Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis

(2014) Nikolaos Alexopoulos et al.   ATHEROSCLEROSIS

Critical role of matrix metalloprotease-9 in chronic high fat diet-induced cerebral vascular remodelling and increase of ischaemic brain injury in mice

(2014) J. Deng et al.   CARDIOVASCULAR RESEARCH

Cardiovascular disease in Europe 2014: epidemiological update

(2014) Melanie Nichols et al.   EUROPEAN HEART JOURNAL

20 YEARS OF LEPTIN: Human disorders of leptin action

(2014) I Sadaf Farooqi et al.   JOURNAL OF ENDOCRINOLOGY

Deregulation of inflammatory response in the diabetic condition is associated with increased ischemic brain injury

(2014) Eunhee Kim et al.   Journal of Neuroinflammation

Obesity-stroke paradox and initial neurological severity

(2014) Yerim Kim et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Trans-sodium crocetinate provides neuroprotection against cerebral ischemia and reperfusion in obese mice

(2014) Jiao Deng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Aging Exacerbates Obesity-induced Cerebromicrovascular Rarefaction, Neurovascular Uncoupling, and Cognitive Decline in Mice

(2014) Z. Tucsek et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology

(2014) Elysse M. Knight et al.   NEUROBIOLOGY OF AGING

Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

(2014) Bing Chun Yan et al.   NEUROCHEMICAL RESEARCH

Modeling Immunity and Inflammation in Stroke

(2014) Frank R. Sharp et al.   STROKE

Control of main risk factors after ischaemic stroke across Europe: data from the stroke-specific module of the EUROASPIRE III survey

(2014) Peter U Heuschmann et al.   European Journal of Preventive Cardiology

Body Mass Index and Death by Stroke

(2014) Christian Dehlendorff et al.   JAMA Neurology

Early effects of high-fat diet on neurovascular function and focal ischemic brain injury

(2013) Weiguo Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Paradoxical effect of obesity on hemorrhagic transformation after acute ischemic stroke

(2013) Chi Kyung Kim et al.   BMC Neurology

Interleukin-6 and activin A are independently associated with cardiovascular events and mortality in type 2 diabetes: the prospective Asker and Bærum Cardiovascular Diabetes (ABCD) cohort study

(2013) Anne Ofstad et al.   Cardiovascular Diabetology

Association of Body Mass Index and Mortality After Acute Ischemic Stroke

(2013) L. E. Skolarus et al.  

Cardiovascular disease in Europe: epidemiological update

(2013) Melanie Nichols et al.   EUROPEAN HEART JOURNAL

The Obesity Paradox in Stroke: Lower Mortality and Lower Risk of Readmission for Recurrent Stroke in Obese Stroke Patients

(2013) Klaus Kaae Andersen et al.   International Journal of Stroke

Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories

(2013) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Immune System in Stroke: Clinical Challenges and Their Translation to Experimental Research

(2013) Craig J. Smith et al.   Journal of Neuroimmune Pharmacology

Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele

(2013) Hiramani Dhungana et al.   Journal of Neuroinflammation

Is There a Decreased Risk of Intracerebral Hemorrhage and Mortality in Obese Patients Treated with Intravenous Thrombolysis in Acute Ischemic Stroke?

(2013) Ameer E. Hassan et al.   Journal of Stroke & Cerebrovascular Diseases

Factors influencing haemorrhagic transformation in ischaemic stroke

(2013) José Álvarez-Sabín et al.   LANCET NEUROLOGY

Exacerbation of ischemic brain injury in hypercholesterolemic mice is associated with pronounced changes in peripheral and cerebral immune responses

(2013) Josephine Herz et al.   NEUROBIOLOGY OF DISEASE

Low cerebral blood flow is associated with lower memory function in metabolic syndrome

(2013) Alex C. Birdsill et al.   Obesity

The Concept of Normal Weight Obesity

(2013) Estefania Oliveros et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Body Fat Distribution and Insulin Resistance

(2013) Pavankumar Patel et al.   Nutrients

CD36 in the periphery and brain synergizes in stroke injury in hyperlipidemia

(2012) Eunhee Kim et al.   ANNALS OF NEUROLOGY

Association Between Interleukin-6 Levels and First-Ever Cerebrovascular Events in Patients With Vascular Risk Factors

(2012) Kaori Miwa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Overweight and obesity are associated with improved survival, functional outcome, and stroke recurrence after acute stroke or transient ischaemic attack: observations from the TEMPiS trial

(2012) W. Doehner et al.   EUROPEAN HEART JOURNAL

Delayed Administration of Interleukin-1 Receptor Antagonist Reduces Ischemic Brain Damage and Inflammation in Comorbid Rats

(2012) Jesus M Pradillo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Obesity paradox or inappropriate study designs? Time for life-course epidemiology

(2012) Isabel Ferreira et al.   JOURNAL OF HYPERTENSION

Relationship of Obesity to Recanalization after Hyperacute Recombinant Tissue-Plasminogen Activator Infusion Therapy in Patients with Middle Cerebral Artery Occlusion

(2012) Ichiro Deguchi et al.   Journal of Stroke & Cerebrovascular Diseases

Thrombolysis Outcomes among Obese and Overweight Stroke Patients: An Age- and National Institutes of Health Stroke Scale–matched Comparison

(2012) Raymond C.S. Seet et al.   Journal of Stroke & Cerebrovascular Diseases

Systemic immune activation shapes stroke outcome

(2012) Katie N. Murray et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dynamics of obesity paradox after stroke, related to time from onset, age, and causes of death

(2012) B. J. Kim et al.   NEUROLOGY

Enhancement of hematopoiesis and lymphopoiesis in diet-induced obese mice

(2012) M. D. Trottier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroinflammation and neurodegeneration in overnutrition-induced diseases

(2012) Dongsheng Cai   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Enhanced endothelin-1 system activity with overweight and obesity

(2011) Brian R. Weil et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Detailed Cardiovascular Characterization of Obesity Without the Metabolic Syndrome

(2011) Lars Lind et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protection against ischemic stroke damage by synergistic treatment with amlodipine plus atorvastatin in Zucker metabolic rat

(2011) Hiromi Kawai et al.   BRAIN RESEARCH

Human obesity and endothelium-dependent responsiveness

(2011) Umberto Campia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Body Mass Index, Initial Neurological Severity and Long-Term Mortality in Ischemic Stroke

(2011) Wi-Sun Ryu et al.   CEREBROVASCULAR DISEASES

Outcome of Intravenous Thrombolysis in Stroke Patients Weighing over 100 kg

(2011) H. Sarikaya et al.   CEREBROVASCULAR DISEASES

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased cerebral matrix metalloprotease-9 activity is associated with compromised recovery in the diabetic db/db mouse following a stroke

(2011) Rashmi Kumari et al.   JOURNAL OF NEUROCHEMISTRY

Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation

(2011) Pratibha V Nerurkar et al.   Journal of Neuroinflammation

Ischemic hippocampal cell death induces glucose dysregulation by attenuating glucose-stimulated insulin secretion which is exacerbated by a high fat diet

(2011) Sunmin Park et al.   LIFE SCIENCES

Exaggerated Neutrophil-Mediated Reperfusion Injury after Ischemic Stroke in a Rodent Model of Type 2 Diabetes

(2011) LESLIE RITTER et al.   MICROCIRCULATION

Long-term exposure to high fat diet is bad for your brain: exacerbation of focal ischemic brain injury

(2011) K.D. Langdon et al.   NEUROSCIENCE

Elevated BMI Is Associated With Decreased Blood Flow in the Prefrontal Cortex Using SPECT Imaging in Healthy Adults

(2011) Kristen C. Willeumier et al.   Obesity

Functional Capacity of Neutrophils From Class III Obese Patients

(2011) Mark D. Trottier et al.   Obesity

Body Weight After Stroke

(2011) Nadja Scherbakov et al.   STROKE

Obesity Paradox and Stroke

(2011) Michael Katsnelson et al.   STROKE

Impact of Obesity on Stroke Outcome After Intravenous Thrombolysis

(2011) Hakan Sarikaya et al.   STROKE

Relation between body mass index, waist circumference, and cardiovascular outcomes in 19,579 diabetic patients with established vascular disease: the REACH Registry

(2011) Jean Dallongeville et al.   European Journal of Preventive Cardiology

Preventing increased blood pressure in the obese Zucker rat improves severity of stroke

(2010) Jessica M. Osmond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Synergistic benefit of combined amlodipine plus atorvastatin on neuronal damage after stroke in Zucker metabolic rat

(2010) Hiromi Kawai et al.   BRAIN RESEARCH

Biochemical Markers for Blood-Brain Barrier Dysfunction in Acute Ischemic Stroke Correlate with Evolution and Outcome

(2010) Raf Brouns et al.   EUROPEAN NEUROLOGY

Association of obesity and biomarkers of inflammation and endothelial dysfunction in adults in Inner Mongolia, China

(2010) Angela M. Thompson et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Experimental Stroke-Induced Changes in the Bone Marrow Reveal Complex Regulation of Leukocyte Responses

(2010) Adam Denes et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exacerbated brain damage, edema and inflammation in type-2 diabetic mice subjected to focal ischemia

(2010) Kudret Tureyen et al.   JOURNAL OF NEUROCHEMISTRY

Association Between Direct Measures of Body Composition and Prognostic Factors in Chronic Heart Failure

(2010) Antigone Oreopoulos et al.   MAYO CLINIC PROCEEDINGS

The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases

(2010) Carmela Rita Balistreri et al.   MEDIATORS OF INFLAMMATION

High-fat diet-induced obesity in animal models

(2010) Niloofar Hariri et al.   NUTRITION RESEARCH REVIEWS

Systemic Effects of White Adipose Tissue Dysregulation and Obesity-Related Inflammation

(2010) Amir J. Guri et al.   Obesity

Excess Body Weight and Incidence of Stroke

(2010) Pasquale Strazzullo et al.   STROKE

Association Between Obesity and Mortality After Acute First-Ever Stroke

(2010) Konstantinos Vemmos et al.   STROKE

White Matter Damage and the Effect of Matrix Metalloproteinases in Type 2 Diabetic Mice After Stroke

(2010) Jieli Chen et al.   STROKE

A useful list of spontaneously arising animal models of obesity and diabetes

(2009) Eleazar Shafrir et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Recent advances in understanding leptin signaling and leptin resistance

(2009) David L. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The associations of interleukin-6 (IL-6) and downstream inflammatory markers with risk of cardiovascular disease: The Caerphilly Study

(2009) Christopher C. Patterson et al.   ATHEROSCLEROSIS

Adiponectin protects against cerebral ischemia–reperfusion injury through anti-inflammatory action

(2009) Bi Chen et al.   BRAIN RESEARCH

Pathophysiological dual action of adiponectin after transient focal ischemia in mouse brain

(2009) Kenji Yatomi et al.   BRAIN RESEARCH

Systemic Fate of the Adipocyte-Derived Factor Adiponectin

(2009) N. Halberg et al.   DIABETES

The PPAR-γ Agonist, Darglitazone, Restores Acute Inflammatory Responses to Cerebral Hypoxia–Ischemia in the Diabetic ob/ob Mouse

(2009) Rashmi Kumari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Rapid and Transient Peripheral Inflammatory Response Precedes Brain Inflammation after Experimental Stroke

(2009) Katie Z Chapman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased Brain Microvascular MMP-9 and Incidence of Haemorrhagic Transformation in Obese Mice after Experimental Stroke

(2009) Barry W McColl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cognitive impairment following high fat diet consumption is associated with brain inflammation

(2009) Paul J. Pistell et al.   JOURNAL OF NEUROIMMUNOLOGY

Diet-induced obesity causes cerebral vessel remodeling and increases the damage caused by ischemic stroke

(2009) Christian Deutsch et al.   MICROVASCULAR RESEARCH

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

(2009) E. Maury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neutrophil Activation in Morbid Obesity, Chronic Activation of Acute Inflammation

(2009) Jeroen Nijhuis et al.   Obesity

The Impact of Body Mass Index on Mortality After Stroke

(2009) Amytis Towfighi et al.   STROKE

Hyperglycemia, diabetes and stroke: Focus on the cerebrovasculature

(2009) Adviye Ergul et al.   VASCULAR PHARMACOLOGY

Hypertension and cerebrovascular damage

(2008) Franco Veglio et al.   ATHEROSCLEROSIS

A high fat diet does not exacerbate CA1 injury and cognitive deficits following global ischemia in rats

(2008) Anastasia P. Arvanitidis et al.   BRAIN RESEARCH

Does Body Weight Influence the Response to Intravenous Tissue Plasminogen Activator in Stroke Patients?

(2008) Min Lou et al.   CEREBROVASCULAR DISEASES

The effects of body mass index on cerebral blood flow velocity

(2008) Magdy Selim et al.   CLINICAL AUTONOMIC RESEARCH

Obesity Increases Blood Pressure, Cerebral Vascular Remodeling, and Severity of Stroke in the Zucker Rat

(2008) Jessica M. Osmond et al.   HYPERTENSION

Acute Treatment with Rosuvastatin Protects Insulin Resistant (C57BL/6J ob/ob) Mice against Transient Cerebral Ischemia

(2008) Keita Mayanagi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CD36/Fatty Acid Translocase, An Inflammatory Mediator, Is Involved in Hyperlipidemia-Induced Exacerbation in Ischemic Brain Injury

(2008) E. Kim et al.   JOURNAL OF NEUROSCIENCE

Body Mass Index and Poststroke Mortality

(2008) Tom Skyhøj Olsen et al.   NEUROEPIDEMIOLOGY

BMI and Stroke Risk in Korean Women

(2008) Ji Wan Park et al.   Obesity

Early Hemorrhagic Transformation of Brain Infarction: Rate, Predictive Factors, and Influence on Clinical Outcome

(2008) Maurizio Paciaroni et al.   STROKE

Inflammatory and Injury Responses to Ischemic Stroke in Obese Mice

(2008) Satoshi Terao et al.   STROKE

The Metabolic Syndrome Is Associated With a Higher Resistance to Intravenous Thrombolysis for Acute Ischemic Stroke in Women Than in Men

(2008) Juan F. Arenillas et al.   STROKE

Leptin Is Induced in the Ischemic Cerebral Cortex and Exerts Neuroprotection Through NF-κB/c-Rel–Dependent Transcription

(2008) Alessandra Valerio et al.   STROKE

Adiponectin Prevents Cerebral Ischemic Injury Through Endothelial Nitric Oxide Synthase–Dependent Mechanisms

(2007) Masaki Nishimura et al.   CIRCULATION

Obesity Exacerbates Sepsis-Induced Inflammation and Microvascular Dysfunction in Mouse Brain

(2007) VIDULA VACHHARAJANI et al.   MICROCIRCULATION