Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts

A Synthetic Small Molecule for Targeted Transcriptional Activation of Germ Cell Genes in a Human Somatic Cell

(2013) Le Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity

(2013) Abhijit Saha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment

(2013) Carla A. Klattenhoff et al.   CELL

KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation

(2013) Laura R. Pearce et al.   CELL

Clinical Grade iPS Cells: Need for Versatile Small Molecules and Optimal Cell Sources

(2013) Yan-Ling Wu et al.   CHEMISTRY & BIOLOGY

The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex

(2013) N. Kurabayashi et al.   DEVELOPMENT

Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling

(2013) Ekatherina Serysheva et al.   EMBO REPORTS

On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms

(2013) L. O. Sun et al.   SCIENCE

Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach

(2013) Shigeo Masuda et al.   Journal of Molecular Cell Biology

Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes

(2012) Ganesh N. Pandian et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design of a new fluorescent probe: Pyrrole/imidazole hairpin polyamides with pyrene conjugation at their γ-turn

(2012) Thangavel Vaijayanthi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Programmable genetic switches to control transcriptional machinery of pluripotency

(2012) Ganesh N. Pandian et al.   Biotechnology Journal

Progress and Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes

(2012) Thangavel Vaijayanthi et al.   CHEMBIOCHEM

Synthesis and Biological Properties of Highly Sequence-Specific-Alkylating N-Methylpyrrole–N-Methylimidazole Polyamide Conjugates

(2012) Gengo Kashiwazaki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell Fusion Reprogramming Leads to a Specific Hepatic Expression Pattern during Mouse Bone Marrow Derived Hepatocyte Formation In Vivo

(2012) Oscar Quintana-Bustamante et al.   PLoS One

Expression of Caytaxin Protein in Cayman Ataxia Mouse Models Correlates with Phenotype Severity

(2012) Kristine M. Sikora et al.   PLoS One

Epigenetic Regulation by Long Noncoding RNAs

(2012) J. T. Lee   SCIENCE

A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts

(2012) Ganesh N. Pandian et al.   Scientific Reports

Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression

(2012) Yi Li et al.   Scientific Reports

Depletion of 14-3-3 Protein Exacerbates Cardiac Oxidative Stress, Inflammation and Remodeling Process via Modulation of MAPK/NF-ĸB Signaling Pathways after Streptozotocin-induced Diabetes Mellitus

(2011) Rajarajan A. Thandavarayan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes in Mouse Embryonic Fibroblasts

(2011) Ganesh N. Pandian et al.   CHEMBIOCHEM

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

TAL Effectors: Customizable Proteins for DNA Targeting

(2011) A. J. Bogdanove et al.   SCIENCE

CD24: A Novel Surface Marker for PDX1-Positive Pancreatic Progenitors Derived from Human Embryonic Stem Cells

(2011) Wei Jiang et al.   STEM CELLS

Epigenetic Mechanisms that Regulate Cell Identity

(2010) María J. Barrero et al.   Cell Stem Cell

Identifying Unexpected Therapeutic Targets via Chemical-Protein Interactome

(2010) Lun Yang et al.   PLoS One

Specificity landscapes of DNA binding molecules elucidate biological function

(2010) C. D. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell permeability of Py–Im-polyamide-fluorescein conjugates: Influence of molecular size and Py/Im content

(2009) Shigeki Nishijima et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Detection of aberrant transcription of major histocompatibility complex class II antigen presentation genes in chronic lymphocytic leukaemia identifiesHLA-DOAmRNA as a prognostic factor for survival

(2009) Yuri Souwer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development

(2009) Ann Ng et al.   DEVELOPMENTAL BIOLOGY

Long noncoding RNAs: functional surprises from the RNA world

(2009) J. E. Wilusz et al.   GENES & DEVELOPMENT

Synthesis and properties of PI polyamide–SAHA conjugate

(2009) Akimichi Ohtsuki et al.   TETRAHEDRON LETTERS

Interstitial deletion of 6q25.2–q25.3: a novel microdeletion syndrome associated with microcephaly, developmental delay, dysmorphic features and hearing loss

(2008) Sandesh Chakravarthy Sreenath Nagamani et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Microarray-based gene expression analysis during retinal maturation of albino rats

(2008) Gil Ben-Shlomo et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY