HYDAMTIQ, a selective PARP-1 inhibitor, improves bleomycin-induced lung fibrosis by dampening the TGF-β/SMAD signalling pathway

Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation

(2016) Michelle L. Manni et al.   JOURNAL OF IMMUNOLOGY

Nintedanib and Pirfenidone. New Antifibrotic Treatments Indicated for Idiopathic Pulmonary Fibrosis Offer Hopes and Raises Questions

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline

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Berberine inhibits Smad and non-Smad signaling cascades and enhances autophagy against pulmonary fibrosis

(2015) Palanivel Chitra et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

(2015) Carmel B. Nanthakumar et al.   NATURE REVIEWS DRUG DISCOVERY

Forced Vital Capacity in Idiopathic Pulmonary Fibrosis — FDA Review of Pirfenidone and Nintedanib

(2015) Banu A. Karimi-Shah et al.   NEW ENGLAND JOURNAL OF MEDICINE

New Therapeutic Targets in Idiopathic Pulmonary Fibrosis. Aiming to Rein in Runaway Wound-Healing Responses

(2014) Neil Ahluwalia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts

(2014) Enrico Conte et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling

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(2014) Domokos Gerö et al.   MOLECULAR MEDICINE

InterMune and Boehringer blaze trails for idiopathic pulmonary fibrosis drugs

(2014) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca2+-permeable AMPA receptors

(2014) E. Gerace et al.   NEUROBIOLOGY OF DISEASE

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

A New Hope for Idiopathic Pulmonary Fibrosis

(2014) Gary M. Hunninghake   NEW ENGLAND JOURNAL OF MEDICINE

Beyond TGFβ – Novel ways to target airway and parenchymal fibrosis

(2014) C.E. Boorsma et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis

(2014) Minoru Inomata et al.   RESPIRATORY RESEARCH

Poly(ADP-ribose) polymerase-1 and its cleavage products differentially modulate cellular protection through NF-kB-dependent signaling

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Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role for DNA Damage Signaling in Pulmonary Arterial Hypertension

(2013) Jolyane Meloche et al.   CIRCULATION

Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis

(2013) Partha Mukhopadhyay et al.   HEPATOLOGY

Poly(ADP-ribose) signaling in cell death

(2013) László Virág et al.   MOLECULAR ASPECTS OF MEDICINE

Sorafenib ameliorates bleomycin-induced pulmonary fibrosis: potential roles in the inhibition of epithelial–mesenchymal transition and fibroblast activation

(2013) Y-L Chen et al.   Cell Death & Disease

Regulation of Myofibroblast Differentiation by Poly(ADP-Ribose) Polymerase 1

(2012) Biao Hu et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes

(2012) Péter Bai et al.   FEBS LETTERS

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase

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Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro: clues for cardiac regeneration

(2011) Silvia Nistri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

(2011) Ajit A. Kulkarni et al.   PLoS One

Poly(ADP-ribose) Polymerase 1 Is Indispensable for Transforming Growth Factor-β Induced Smad3 Activation in Vascular Smooth Muscle Cell

(2011) Dan Huang et al.   PLoS One

Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ

(2011) Roberto Pellicciari et al.   MedChemComm

An Official Research Policy Statement of the American Thoracic Society/European Respiratory Society: Standards for Quantitative Assessment of Lung Structure

(2010) Connie C. W. Hsia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fibrogenic Reactions in Lung Disease

(2010) Jun Araya et al.   Annual Review of Pathology-Mechanisms of Disease

The roles of PARP1 in gene control and cell differentiation

(2010) Yingbiao Ji et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Prevention of Bleomycin-Induced Pulmonary Fibrosis by a Novel Antifibrotic Peptide with Relaxin-Like Activity

(2010) A. Pini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications

(2010) Rupinder K. Sodhi et al.   VASCULAR PHARMACOLOGY

Recent Advances in Molecular Targets and Treatment of Idiopathic Pulmonary Fibrosis: Focus on TGFβ Signaling and the Myofibroblast

(2009) M. Gharaee-Kermani et al.   CURRENT MEDICINAL CHEMISTRY

Update in idiopathic pulmonary fibrosis

(2009) Stephen K Frankel et al.   CURRENT OPINION IN PULMONARY MEDICINE

Murine models of pulmonary fibrosis

(2007) Bethany B. Moore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY