Article
Chemistry, Physical
Gloria Lee, Gregor Leech, Pancy Lwin, Jonathan Michel, Christopher Currie, Michael J. Rust, Jennifer L. Ross, Ryan J. McGorty, Moumita Das, Rae M. Robertson-Anderson
Summary: This study combines microscale experiments with mechanistic modeling to investigate how connectivity, rigidity, and force-generation affect emergent material properties in composite networks of actin, tubulin, and myosin in the cytoskeleton. The research reveals that percolated actomyosin networks are essential for contraction, and a critical fraction of microtubules is necessary to sustain controlled dynamics. The comprehensive phase map presented not only provides important insight into different routes the cytoskeleton can use to alter its dynamics and structure, but also serves as a blueprint for designing cytoskeleton-inspired materials with tunability, resilience, and adaptability for diverse applications.
Review
Cell Biology
Niv Ierushalmi, Kinneret Keren
Summary: Symmetry breaking is crucial for the formation of cell structure and function, enabling cell movement, division, and polarity establishment. The mechanisms of symmetry breaking, while diverse, often share common characteristics like nematic, polar, and chiral cytoskeletal symmetry breaking in animal cells. These mechanisms involve both chemical and mechanical processes that cooperate to break symmetry in a robust manner.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Urko Del Castillo, Rosalind Norkett, Wen Lu, Anna Serpinskaya, Vladimir Gelfand
Summary: Ataxin-2 plays a crucial role in regulating neuronal cytoskeletal dynamics and organelle trafficking, as evidenced by fruit fly models, where its loss led to defects in nervous system development and survival.
Article
Biochemistry & Molecular Biology
Kazuo Katoh
Summary: The study revealed that Src protein tyrosine kinases play crucial roles in cell polarity formation and elongation, with the expression and regulation of Src being essential for polarity formation during cell elongation.
Article
Cell & Tissue Engineering
Allison P. Kann, Margaret Hung, Wei Wang, Jo Nguyen, Penney M. Gilbert, Zhuhao Wu, Robert S. Krauss
Summary: Stem cells in tissues can be activated upon injury to repair tissue damage, but the mechanisms by which they sense injury and transition from quiescence to activation are not well understood. A study has found that stem cells in skeletal muscle have specific cytoplasmic projections that can respond to injury and drive downstream activation events through the Rho/ROCK signaling pathway. This mechanism is conserved across different activation models.
Article
Nanoscience & Nanotechnology
Chikahiro Imashiro, Byungjun Kang, Yunam Lee, Youn-Hoo Hwang, Seonghun Im, Dae-Eun Kim, Kenjiro Takemura, Hyungsuk Lee
Summary: Collective cell migration is critical in various physiological and pathological processes, and this study investigated the effect of propagating acoustic waves on such migration behavior. The research found that cell migration was enhanced at a critical wave intensity but suppressed at higher intensities. The observed increased migration was potentially due to cell orientation alignment and thicker actin bundles indicative of higher traction force in response to the acoustic stimulation.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Multidisciplinary Sciences
Lea Reuter, Tanja Schmidt, Prabha Manishankar, Christian Throm, Jutta Keicher, Andrea Bock, Irina Droste-Borel, Claudia Oecking
Summary: NPH3 plays a crucial role in auxin-dependent plant phototropism, with blue light triggering its dissociation from the plasma membrane through phosphorylation and interaction with 14-3-3 proteins. In darkness, NPH3 binds polyacidic phospholipids for membrane association. The dynamic change in NPH3 localization mediated by 14-3-3 is essential for auxin-dependent phototropism.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Byoung-San Moon, David Huang, Fan Gao, Mingyang Cai, Guochang Lyu, Lei Zhang, Jun Chen, Wange Lu
Summary: Nuclear architecture plays a crucial role in the transcriptional programs that determine cell identity. In this study, the researchers identified and characterized extreme long-range chromatin interactions of the Oct4 distal enhancer (DE) using a novel CRISPR labeling technique and chromosome conformation capture. They found that lethal giant larvae 2 (Llgl2) and growth factor receptor-bound protein 7 (Grb7) were putative functional interacting target genes of Oct4 DE on different chromosomes. The study demonstrated that these long-range interactions are important for maintaining pluripotency.
CELL DEATH DISCOVERY
(2023)
Article
Ecology
Giovanni Scarinci, Victor Sourjik
Summary: Mutualistic exchange of metabolites plays a crucial role in microbial communities. In turbulent aquatic environments, direct cell-cell adhesion and bacterial motility enhance cooperative interactions and stabilize metabolic communities.
Review
Biochemistry & Molecular Biology
Leia Colin, Felix Ruhnow, Jian-Kang Zhu, Chunzhao Zhao, Yang Zhao, Staffan Persson
Summary: Salt stress causes ionic toxicity, osmotic stress, and oxidative stress, directly affecting plant growth and development. Plants perceive salt stress through the cell wall and coordinate effective responses. Some mechanisms underlying these processes have been elucidated.
Article
Medicine, Research & Experimental
Yoshinori Matsumoto, Jose La Rose, Oliver A. Kent, Melany J. Wagner, Masahiro Narimatsu, Aaron D. Levy, Mitchell H. Omar, Jiefei Tong, Jonathan R. Krieger, Emily Riggs, Yaryna Storozhuk, Julia Pasquale, Manuela Ventura, Behzad Yeganeh, Martin Post, Michael F. Moran, Marc D. Grynpas, Jeffrey L. Wrana, Giulio Superti-Furga, Anthony J. Koleske, Ann Marie Pendergast, Robert Rottapel
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Multidisciplinary Sciences
Aaditya Khatri, Bryan D. Kraft, Purushothama Rao Tata, Scott H. Randell, Claude A. Piantadosi, Ann Marie Pendergast
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Review
Oncology
Peter E. Fecci, Cosette D. Champion, Jacob Hoj, Courtney M. McKernan, C. Rory Goodwin, John P. Kirkpatrick, Carey K. Anders, Ann Marie Pendergast, John H. Sampson
CLINICAL CANCER RESEARCH
(2019)
Article
Cell Biology
Jacob P. Hoj, Benjamin Mayro, Ann Marie Pendergast
Article
Multidisciplinary Sciences
Jacob P. Hoj, Benjamin Mayro, Ann Marie Pendergast
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Cell Biology
Jillian Hattaway Luttman, Ashley Colemon, Benjamin Mayro, Ann Marie Pendergast
Summary: ABL kinases are involved in promoting tumor progression and metastasis in solid tumors, with their inhibition potentially serving as a novel treatment approach for advanced metastatic disease.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Cell Biology
Jillian Hattaway Luttman, Jacob P. Hoj, Kevin H. Lin, Jiaxing Lin, Jing Jin Gu, Clay Rouse, Amanda G. Nichols, Nancie J. MacIver, Kris C. Wood, Ann Marie Pendergast
Summary: Targeting mitochondrial metabolism and the mevalonate pathway through ABL tyrosine kinase inhibition and statin therapy can synergistically decrease the survival of metastatic lung cancer cells, leading to decreased metastatic outgrowth and increased survival rates for patients with advanced lung cancer.
Article
Cell Biology
Courtney M. McKernan, Aaditya Khatri, Molly Hannigan, Jessica Child, Qiang Chen, Benjamin Mayro, David Snyder, Christopher V. Nicchitta, Ann Marie Pendergast
Summary: The study found that ABL kinase allosteric inhibitors can improve overall survival and impair brain metastasis in patients with HER2-positive breast cancer. Mechanistically, ABL kinase phosphorylates Y-box-binding protein 1 (YB-1), disrupting its binding to the HER2 gene and leading to a decrease in HER2 protein levels. Loss of YB-1 also inhibits the development of brain metastasis and impairs the expression of ABL-dependent brain metastatic targets.
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Review
Oncology
Hannah L. Thrash, Ann Marie Pendergast
Summary: YAP and TAZ, as transcriptional co-activators in the Hippo pathway, play important roles in tumor progression and metastasis. This review provides insights into their structure, regulation, and their roles in tumor invasion and metastatic spread. It also discusses potential therapeutic strategies targeting YAP/TAZ in different types of solid tumors.
Article
Multidisciplinary Sciences
Jing Jin Gu, Jacob Hoj, Clay Rouse, Ann Marie Pendergast