3D culture models of tissues under tension

Forces driving cell sorting in the amphibian embryo

(2017) Rudolf Winklbauer et al.   MECHANISMS OF DEVELOPMENT

Myofibroblast persistence with real-time changes in boundary stiffness

(2016) Mehmet H. Kural et al.   Acta Biomaterialia

Harnessing cellular-derived forces in self-assembled microtissues to control the synthesis and alignment of ECM

(2016) Jacquelyn Y. Schell et al.   BIOMATERIALS

Quick and easy microfabrication of T-shaped cantilevers to generate arrays of microtissues

(2016) Benoît Kalman et al.   BIOMEDICAL MICRODEVICES

Complex Tissue and Disease Modeling using hiPSCs

(2016) Robert Passier et al.   Cell Stem Cell

Measuring cell-generated forces: a guide to the available tools

(2016) William J Polacheck et al.   NATURE METHODS

Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities

(2016) Sisi Chen et al.   Nature Communications

Cellular forces and matrix assembly coordinate fibrous tissue repair

(2016) Mahmut Selman Sakar et al.   Nature Communications

Full-Length Fibronectin Drives Fibroblast Accumulation at the Surface of Collagen Microtissues during Cell-Induced Tissue Morphogenesis

(2016) Jasper Foolen et al.   PLoS One

Lung Microtissue Array to Screen the Fibrogenic Potential of Carbon Nanotubes

(2016) Zhaowei Chen et al.   Scientific Reports

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Programmed synthesis of three-dimensional tissues

(2015) Michael E Todhunter et al.   NATURE METHODS

Forcing cells into shape: the mechanics of actomyosin contractility

(2015) Michael Murrell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity

(2015) Alec E. Cerchiari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

(2015) J. T. Hinson et al.   SCIENCE

Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes

(2015) Philippe Beauchamp et al.   TISSUE ENGINEERING PART C-METHODS

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

Computational and experimental investigation of local stress fiber orientation in uniaxially and biaxially constrained microtissues

(2014) Christine Obbink-Huizer et al.   Biomechanics and Modeling in Mechanobiology

Remodeling of Fibrous Extracellular Matrices by Contractile Cells: Predictions from Discrete Fiber Network Simulations

(2014) A.S. Abhilash et al.   BIOPHYSICAL JOURNAL

The influence of matrix (an)isotropy on cardiomyocyte contraction in engineered cardiac microtissues

(2014) A. C. C. van Spreeuwel et al.   Integrative Biology

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo

(2014) M. Juhas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfabrication and microfluidics for muscle tissue models

(2014) Sebastien G.M. Uzel et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Decoupling Cell and Matrix Mechanics in Engineered Microtissues Using Magnetically Actuated Microcantilevers

(2013) Ruogang Zhao et al.   ADVANCED MATERIALS

Tissue mechanics and fibrosis

(2013) Rebecca G. Wells   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanoregulation of valvular interstitial cell phenotype in the third dimension

(2013) Mehmet H. Kural et al.   BIOMATERIALS

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Necking and failure of constrained 3D microtissues induced by cellular tension

(2013) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues

(2013) N. Thavandiran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micro-Mold Design Controls the 3D Morphological Evolution of Self-Assembling Multicellular Microtissues

(2013) Alexander A. Svoronos et al.   TISSUE ENGINEERING PART A

Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle

(2012) Adrian R. West et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Fibroblast cluster formation on 3D collagen matrices requires cell contraction dependent fibronectin matrix organization

(2012) Bruno da Rocha-Azevedo et al.   EXPERIMENTAL CELL RESEARCH

Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis

(2012) Wesley R. Legant et al.   Integrative Biology

Formation and optogenetic control of engineered 3D skeletal muscle bioactuators

(2012) Mahmut Selman Sakar et al.   LAB ON A CHIP

Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells

(2012) J.-L. Maitre et al.   SCIENCE

Mechanochemical Control of Mesenchymal Condensation and Embryonic Tooth Organ Formation

(2011) Tadanori Mammoto et al.   DEVELOPMENTAL CELL

Nanolithographic Control of the Spatial Organization of Cellular Adhesion Receptors at the Single-Molecule Level

(2011) Mark Schvartzman et al.   NANO LETTERS

Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells

(2011) L. Chanson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues

(2011) Thomas Boudou et al.   TISSUE ENGINEERING PART A

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact

(2010) Joseph P. Califano et al.   Cellular and Molecular Bioengineering

Measurement of mechanical tractions exerted by cells in three-dimensional matrices

(2010) Wesley R Legant et al.   NATURE METHODS

Ontogeny-recapitulating generation and tissue integration of ES cell–derived Purkinje cells

(2010) Keiko Muguruma et al.   NATURE NEUROSCIENCE

Coaction of intercellular adhesion and cortical tension specifies tissue surface tension

(2010) M. Lisa Manning et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

Boundary Stiffness Regulates Fibroblast Behavior in Collagen Gels

(2009) Jeffrey John et al.   ANNALS OF BIOMEDICAL ENGINEERING

Substrate Topography Induces a Crossover from 2D to 3D Behavior in Fibroblast Migration

(2009) Marion Ghibaudo et al.   BIOPHYSICAL JOURNAL

Use of rapidly mineralising osteoblasts and short periods of mechanical loading to accelerate matrix maturation in 3D scaffolds

(2009) Anuphan Sittichockechaiwut et al.   BONE

The extracellular matrix in development and morphogenesis: A dynamic view

(2009) Tania Rozario et al.   DEVELOPMENTAL BIOLOGY

Programmed assembly of 3-dimensional microtissues with defined cellular connectivity

(2009) Z. J. Gartner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues

(2009) W. R. Legant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiomyogenic Differentiation of Embryoid Bodies Is Promoted by Rotary Orbital Suspension Culture

(2009) Carolyn Y. Sargent et al.   TISSUE ENGINEERING PART A

Mechanotransduction in osteoblast regulation and bone disease

(2009) Katerina K. Papachroni et al.   TRENDS IN MOLECULAR MEDICINE

Molecular Bases of Cell-Cell Junctions Stability and Dynamics

(2009) M. Cavey et al.   Cold Spring Harbor Perspectives in Biology

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

(2008) Karl E Kadler et al.   CURRENT OPINION IN CELL BIOLOGY

Tensile forces govern germ-layer organization in zebrafish

(2008) M. Krieg et al.   NATURE CELL BIOLOGY