Article
Multidisciplinary Sciences
Shaohua Zhang, Huan Zhao, Zixin Liu, Kuo Liu, Huan Zhu, Wenjuan Pu, Lingjuan He, Rong A. Wang, Bin Zhou
Summary: Monitoring cell-cell communication is crucial for understanding biological processes. Researchers have developed a genetic technology that can track and label cell-cell contacts, allowing for the study of dynamic cell-cell interactions in vivo.
Article
Cell Biology
Josie F. Gibson, Tomasz K. Prajsnar, Christopher J. Hill, Amy K. Tooke, Justyna J. Serba, Rebecca D. Tonge, Simon J. Foster, Andrew J. Grierson, Philip W. Ingham, Stephen A. Renshaw, Simon A. Johnston
Summary: This study reveals the fate and location of Staphylococcus aureus within neutrophils, showing that recruitment of Lc3 and Sqstm1 to phagocytosed bacteria depends on bacterial location. Additionally, it demonstrates the key role of Sqstm1 in controlling cytosolic bacteria.
Article
Biology
Kevin S. Chen, Rui Wu, Marc H. Gershow, Andrew M. Leifer
Summary: Olfactory navigation plays a crucial role in the survival of animals and is observed across species. This study presents a method to control and measure airborne odor concentration in an arena compatible with an agar substrate, allowing continuous monitoring of odor profile while imaging animal behavior. The researchers successfully measured the odor concentration experienced by C. elegans and D. melanogaster larvae populations as they navigate spatial odor landscapes.
Article
Biochemistry & Molecular Biology
Lorenzo Badenetti, Rosa Manzoli, Michela Rubin, Giorgio Cozza, Enrico Moro
Summary: Among cytoprotective mechanisms, eukaryotic cells rely on the Nrf2 transcription factor to initiate a complex transcriptional program during biological stressors, including oxidative stress. Nrf2 has recently been found to play a crucial role in various research fields, such as cancer, inflammatory disorders, and age-related neurological diseases. In this study, a novel Nrf2/ARE pathway biosensor fish was generated and characterized, demonstrating spatiotemporal expression during early development. This transgenic fish shows responsiveness to Nrf2 pathway modulators and Edaravone, which has not been seen in any live transgenic fish models before. The activated reporter in this fish is also shown to be faithful during fin regeneration and slightly affected in a glucocerebrosidase morphant zebrafish model. Therefore, this innovative transgenic fish can serve as a valuable tool for studying zebrafish models of human diseases and primary high-throughput drug screening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nanoscience & Nanotechnology
Yifan Da, Shihua Luo, Yang Tian
Summary: This Review focuses on the progress in the construction of sensors for in vivo analysis of neurotransmitters in the brain and summarizes current attempts to address key issues in the development of sensors with high selectivity, sensitivity, and stability. Several strategies for sensor construction are provided for recording chemical signal changes in the complex environment of the brain, combined with the latest advances in technologies and methods.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Agronomy
Suresh Neethirajan
Summary: Sensor-enabled big data and artificial intelligence platforms have the potential to address global socio-economic trends related to the livestock production sector. However, current digital approaches do not meet the challenges due to a lack of efficient and real-time non-invasive precision measurement technologies that can detect and monitor animal diseases and identify resilience in animals.
Article
Microbiology
J. Caballero-Gomez, I. Garcia-Bocanegra, N. Navarro, R. Guerra, E. Martinez-Nevado, P. Soriano, D. Cano-Terriza
Summary: The study conducted a serosurvey on Schmallenberg virus exposure in zoo animals in Spain, identifying the order (Artiodactyla) and a zoo in southern Spain as potential risk factors associated with exposure. Two longitudinally-sampled individuals showed specific antibodies against SBV at all sampling times, indicating potential immunity build-up in certain animals.
VETERINARY MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ji-Won Seo, Kaiyu Fu, Santiago Correa, Michael Eisenstein, Eric A. Appel, Hyongsok T. Soh
Summary: This study developed an implantable microelectrode array sensor to collect tissue-based pharmacokinetic data in tumors, demonstrating clear differences in drug pharmacokinetics relative to the systemic circulation. The platform may be valuable for preclinical characterization of cancer therapeutics and could have future clinical applications.
Article
Engineering, Electrical & Electronic
Chaehyun Kim, Ahram Jang, Sebin Kim, Sungbo Cho, Donghun Lee, Young-Joon Kim
Summary: In this study, a simple and minimally invasive ECG measurement system for mice was developed. It consists of a miniaturized wearable ECG monitoring device and a smartphone application that displays real-time ECG waveform and heart rate. The system proved to be feasible through validation experiments.
IEEE SENSORS JOURNAL
(2023)
Review
Agriculture, Dairy & Animal Science
Xin Zhao, Weican Wan, Xianyu Zhang, Zhenfang Wu, Huaqiang Yang
Summary: Spermatogonial stem cell transplantation (SSCT) can restore male fertility by transferring germline between donor and recipient males. From an agricultural perspective, SSCT could be an important next-generation reproductive and breeding tool in livestock production. Current SSCT approaches in large animals are inefficient, and further investigation is needed for many technical details.
Review
Radiology, Nuclear Medicine & Medical Imaging
Chintan Chawda, Roisin McMorrow, Natasa Gaspar, Giorgia Zambito, Laura Mezzanotte
Summary: The use of transgenic mouse models with optical reporter genes enables in vivo imaging of cellular and molecular events, as well as accurately distinguishing immune cell types and their activities. These models are essential for studying immune cell function and evaluating the effects of immunotherapies against diseases like cancer.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Infectious Diseases
Javier Caballero-Gomez, David Cano Terriza, Joan Pujols, Eva Martinez-Nevado, M. Dolores Carbonell, Rafael Guerra, Jesus Recuero, Pilar Soriano, Jesus Barbero, Ignacio Garcia-Bocanegra
Summary: The study found exposure to Bluetongue virus (BTV) in zoo animals in Spain, with some animals showing persistent seropositivity during the study period and others experiencing seroconversions in specific years. This is the first large-scale survey on BTV in both artiodactyl and non-artiodactyl zoo species worldwide. The results suggest potential animal health and conservation concerns regarding BTV circulation in urban zoo parks.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Yasin Cotur, Selin Olenik, Tarek Asfour, Michael Bruyns-Haylett, Michael Kasimatis, Ugur Tanriverdi, Laura Gonzalez-Macia, Hong Seok Lee, Andrei S. Kozlov, Firat Guder
Summary: This article introduces a continuous wearable respiration sensor inspired by the lateral line system of fish, capable of detecting mechanical disturbances in water. The sensor continuously measures respiratory activity by sensing the force applied to an air channel embedded in silicone-based elastomeric material, potentially enabling early detection of disorders resulting in altered respiratory patterns.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Aleksey Yevtodiyenko, Arkadiy Bazhin, Pavlo Khodakivskyi, Aurelien Godinat, Ghyslain Budin, Tamara Maric, Giorgio Pietramaggiori, Sandra S. Scherer, Marina Kunchulia, George Eppeldauer, Sergey Polyakov, Kevin P. Francis, Jeffrey N. Bryan, Elena A. Goun
Summary: Bioluminescent imaging usually relies on transgenic luciferase-expressing cells and animals, but the portable bioluminescent technology developed in this study can noninvasively measure intra- and extracellular enzyme activity in vivo in non-transgenic animals, showing promising potential for a wide range of applications.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Tyler J. Bechtel, Tamara Reyes-Robles, Olugbeminiyi O. Fadeyi, Rob C. Oslund
Summary: Multicellular organisms rely on physical cell-cell interactions to regulate physiological processes. Understanding the complexity of these interactions has greatly improved insight into cell-cell engagement biology and led to opportunities for therapeutic development. Emerging approaches that combine chemistry and biology technologies effectively interrogate cell-cell interfaces with molecular-level detail.
NATURE CHEMICAL BIOLOGY
(2021)
