Sortilin regulates sorting and secretion of Sonic hedgehog

Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling

(2015) Gisela D’Angelo et al.   DEVELOPMENTAL CELL

Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion

(2015) Anup Parchure et al.   MOLECULAR BIOLOGY OF THE CELL

Development of astrocytes in the vertebrate eye

(2014) Chenqi Tao et al.   DEVELOPMENTAL DYNAMICS

The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

(2014) Tamás Matusek et al.   NATURE

Hedgehog and its circuitous journey from producing to target cells

(2014) Isabel Guerrero et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion

(2014) Ana-Citlali Gradilla et al.   Nature Communications

Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties

(2014) Neha Vyas et al.   Scientific Reports

Derlin2 Protein Facilitates HRD1-mediated Retro-translocation of Sonic Hedgehog at the Endoplasmic Reticulum

(2013) Chih-Hsiang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Intracellular Domain of Sortilin Interacts with Amyloid Precursor Protein and Regulates Its Lysosomal and Lipid Raft Trafficking

(2013) Miao Yang et al.   PLoS One

LRP1 mediates Hedgehog-induced endocytosis of the GPC3-Hedgehog complex

(2012) M. I. Capurro et al.   JOURNAL OF CELL SCIENCE

A Genome-Wide RNAi Screen Identifies Regulators of Cholesterol-Modified Hedgehog Secretion in Drosophila

(2012) Reid Aikin et al.   PLoS One

Precursor of Brain-derived Neurotrophic Factor (proBDNF) Forms a Complex with Huntingtin-associated Protein-1 (HAP1) and Sortilin That Modulates proBDNF Trafficking, Degradation, and Processing

(2011) Miao Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Brain-derived Neurotrophic Factor Is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation

(2011) Sarah Felice Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

(2011) Xin Chen et al.   JOURNAL OF CELL BIOLOGY

Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling

(2011) Fuchuan Li et al.   JOURNAL OF CELL BIOLOGY

Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium

(2011) A. Callejo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons

(2010) Shawn T. Beug et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

(2010) Christian B Vaegter et al.   NATURE NEUROSCIENCE

ProNGF induces TNFα-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway

(2010) Frédéric Lebrun-Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes

(2009) Jibin Zeng et al.   EXPERIMENTAL CELL RESEARCH

The Full-length Unprocessed Hedgehog Protein Is an Active Signaling Molecule

(2009) Robert Tokhunts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sortilin mediates the lysosomal targeting of cathepsins D and H

(2008) Maryssa Canuel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells

(2008) Gabriel D. Dakubo et al.   BRAIN RESEARCH

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

(2008) C. E. Chamberlain et al.   DEVELOPMENT

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes

(2008) Laura Trinkle-Mulcahy et al.   JOURNAL OF CELL BIOLOGY

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

(2008) Ola Söderberg et al.   METHODS