Review
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: Aging is caused by the accumulation of molecular and cellular damage over time. SIRT7, an enzyme with important functions in aging and life extension, has been found to be closely related to age-related processes and may be associated with certain age-related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Silvia Santana-Sosa, Emiliano Matos-Perdomo, Jessel Ayra-Plasencia, Felix Machin
Summary: The morphology of the nucleus is typically spherical in eukaryotic cells, but it can change during cell migration and division. This is important because abnormal nuclear morphology is associated with cancer and aging, and targeting nuclear shaping pathways and proteins can be used in therapies. Recent evidence also suggests a connection between nuclear shape and lysosomal function in tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Anastasia McKinlay, Dalen Fultz, Feng Wang, Craig S. Pikaard
Summary: This paper presents a simple method for achieving greater than tenfold enrichment of Arabidopsis thaliana 45S rRNA gene sequences among ultra-long sequencing reads, providing a new approach for locating missing regions.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Katrin Schwank, Catharina Schmid, Tobias Fremter, Christoph Engel, Philipp Milkereit, Joachim Griesenbeck, Herbert Tschochner
Summary: Ribosomal RNAs are important components of ribosomes and are primarily synthesized by RNA polymerase I. Many copies of rRNA genes are transcribed by this enzyme, ensuring efficient and accurate rRNA synthesis.
BIOLOGICAL CHEMISTRY
(2023)
Article
Plant Sciences
Craig S. S. Pikaard, Chinmayi Chandrasekhara, Anastasia McKinlay, Ramya Enganti, Dalen Fultz
Summary: Nucleolus organizer regions (NORs) are chromosomal loci where rRNA genes are clustered. NORs have been found to exhibit morphological differences in interspecific hybrids, which correlate with differences in rRNA gene transcription, known as nucleolar dominance. Studies have shown that nucleolar dominance is a result of selective rRNA gene silencing, involving chromatin modifications, and can occur in pure species as well as hybrids. Recent evidence suggests that silencing depends on the NOR location rather than the gene sequence.
Article
Biochemistry & Molecular Biology
Mason A. A. McCool, Carson J. J. Bryant, Hannah Huang, Lisa M. M. Ogawa, Katherine I. I. Farley-Barnes, Samuel B. B. Sondalle, Laura Abriola, Yulia V. V. Surovtseva, Susan J. J. Baserga
Summary: The U3 Associated Proteins (UTPs) are highly conserved components of eukaryotic ribosome biogenesis. While the counterparts of most yeast Utps have been identified in humans, the homologs of Utp9 and Bud21 have remained elusive. In this study, NOL7 is identified as the likely ortholog of Bud21 and is shown to be required for early pre-rRNA accumulation and processing in human cells.
Article
Biochemistry & Molecular Biology
Eunji Kim, Ilmin Kwon
Summary: Fibrillarin, a key nucleolar protein, undergoes a phase transition regulated by phenylalanine residues in its LC domain, which is crucial for its localization in nucleoli and interaction with RNA binding proteins.
BIOCHEMICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Josh Lawrimore, Daniel Kolbin, John Stanton, Muznah Khan, Solenn C. de Larminat, Colleen Lawrimore, Elaine Yeh, Kerry Bloom
Summary: The nucleolus is the site of ribosome biosynthesis, where the rDNA locus and Cdc14 protein behave like a condensate formed by polymer-polymer phase separation, while ribonucleoproteins behave like a condensate formed by liquid-liquid phase separation. The compaction and distribution in the nucleolus are dependent on the concentration of DNA cross-linkers.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ying Ting Chao, Sheng Hao Lai, Mei Hsun Chang, Chun Chi Chen, Wei Feng Lee, Jing Wen Chen, Yi Chiung Hsu
Summary: This study analyzed soil samples collected in Southern Taiwan immediately after the 2010 earthquake to detect microbial community abundance and composition. The results revealed that the Nitrospirae phylum dominated in the liquefied layer, with the genus HB118 only present in this layer. This suggests changes in microbial community composition at different soil depths post-earthquakes, providing a useful indicator for monitoring liquefied soil.
Article
Biochemistry & Molecular Biology
Eun Seon Kim, Chang Geon Chung, Jeong Hyang Park, Byung Su Ko, Sung Soon Park, Yoon Ha Kim, In Jun Cha, Jaekwang Kim, Chang Man Ha, Hyung-Jun Kim, Sung Bae Lee
Summary: It has been found in a Drosophila model that nuclear accumulation of the RNA-binding protein Staufen may be a crucial pathological feature contributing to ALS/FTD. The nuclear accumulation of Staufen could potentially enhance the toxicity of certain proteins, and regulating the levels of Fibrillarin may affect the degree of cellular toxicity caused by protein aggregates.
HUMAN MOLECULAR GENETICS
(2021)
Review
Cell Biology
Shuang Feng, James L. Manley
Summary: Nucleoli are important cellular compartments for the synthesis of rRNA and assembly of ribosomes. In addition to producing rRNAs, nucleoli are also involved in the transcription of noncoding and coding RNAs, which often exhibit species-specific features and are transcribed by different polymerases. These transcripts play a role in regulating rRNA transcription, nucleolar structure, and cellular homeostasis.
GENES & DEVELOPMENT
(2022)
Article
Immunology
Valentin Joste, Justine Bailly, Veronique Hubert, Cecile Pauc, Mathieu Gendrot, Emilie Guillochon, Marylin Madamet, Marc Thellier, Eric Kendjo, Nicolas Argy, Bruno Pradines, Sandrine Houze
Summary: This activity is a medical continuing education program aimed at improving patient care. Participants can earn CME credits and MOC points upon successful completion, with the responsibility to submit completion information for credit allocation. The process involves learning, testing, evaluation, and certificate issuance for participants.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Aubrey R. Odom, Tyler Faits, Eduardo Castro-Nallar, Keith A. Crandall, W. Evan Johnson
Summary: This study evaluated the accuracy of several bioinformatics tools and genomic reference libraries using simulated 16S sequencing data. The results showed that PathoScope 2 and Kraken 2 performed well in accurately classifying genera and species.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Katherine A. A. Maki, Brian Wolff, Leonardo Varuzza, Stefan J. J. Green, Jennifer J. J. Barb
Summary: This methodology study aimed to develop two analysis pipelines for mixed-orientation reads from multi-hypervariable (V) region amplicons and assess their agreement with expected abundance. Mock community sequence data generated using the Ion16S Metagenomics Kit and Ion Torrent Sequencing Platform were analyzed using two workflows.
Article
Multidisciplinary Sciences
Takahiro Iijima, Shinnosuke Ando, Dai Kanamori, Kazumichi Kuroda, Tsutomu Nomura, Laurence Tisi, Paul E. Kilgore, Neil Percy, Hikaru Kohase, Satoshi Hayakawa, Mitsuko Seki, Tomonori Hoshino
Summary: This study describes a new detection method combining reverse transcription loop-mediated isothermal amplification (RT-LAMP) and bioluminescent assay in real-time (BART), which can detect the new coronavirus and its variants rapidly and accurately. The method has high specificity and is faster than the conventional real-time RT-PCR method. Additionally, it can correctly identify spike protein mutations.
Article
Chemistry, Physical
Edouard Boivin, Sebastien Saitzek, Francois Fauth, Marielle Huve, Pascal Roussel, Houria Kabbour
Summary: In this study, new potential photocatalysts for overall water splitting (OWS) are obtained through kinetically controlled ion exchange reaction from Na2M2O5F2. These photocatalysts contain lone pair containing oxyfluorides and have a pyrochlore structure. The Sn2+ lone pair stereochemical activity and the narrowing of the band gap contribute to their improved photoconduction response.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Aiman Jrondi, Gaetan Buvat, Francisco De La Pena, Maya Marinova, Marielle Huve, Thierry Brousse, Pascal Roussel, Christophe Lethien
Summary: Vanadium nitride films made by magnetron sputtering method show excellent cycling stability, high rate capability, high surface capacitance values, and little aging of the electrodes. Additionally, new findings about the charge storage mechanism in pseudocapacitive VN films are revealed by nanoscale analysis.
ADVANCED ENERGY MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Rafik Benrabaa, Martine Trentesaux, Pascal Roussel, Annick Rubbens, Rose-Noelle Vannier, Axel Lofberg
Summary: NiAlxFe2_xO4 was synthesized and evaluated in methane reforming without pretreatment. The precursor nature significantly influenced the structural, textural, and reactivity properties. The aluminum compound exhibited high catalytic activity, while NiFe2O4 showed poor activity. Powders prepared with chlorides were more active at low temperatures, but this trend diminished at high temperatures. NiAl2O4 from nitrate precursors showed the best catalytic performance.
JOURNAL OF CO2 UTILIZATION
(2023)
Article
Chemistry, Multidisciplinary
Ankush Bhatia, Maxime Hallot, Clement Leviel, Pascal Roussel, Jean-Pierre Pereira-Ramos, Christophe Lethien, Rita Baddour-Hadjean
Summary: Investigation of electrochemical lithium (de)intercalation in an atomic layer deposited (ALD) TiO2 anatase thin film on a Si/Al2O3/Pt substrate was performed using Raman spectroscopy. The initial discharge capacity at C/10 rate was 63 mu Ah cm(-2) mu m(-1) (0.5 Li+ mole(-1)), which increased to 77 mu Ah cm(-2) mu m(-1) after further cycles. The ALD thin film exhibited excellent capacity retention over 100 cycles, indicating its good adherence. Raman spectra of LixTiO2 (0 <= x <= 0.5) thin film electrodes suggest the nucleation of the orthorhombic lithiated titanate (LT) Li0.5TiO2 phase at x = 0.1. The LT phase coexisted with tetragonal TiO2 in the composition range of 0.1 <= x <= 0.4, and was pure at x = 0.5. Reversible transformation from orthorhombic LT to tetragonal TiO2 was observed during charging. The high quality of the Raman spectra allowed identification of 12 modes in the 100-800 cm(-1) region for the electrochemically formed LT phase. Raman spectroscopy proved to be a powerful tool for investigating the Li insertion/extraction mechanism in TiO2 thin films.
ADVANCED MATERIALS INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Khac Huy Dinh, Pascal Roussel, Christophe Lethien
Summary: Microsupercapacitors (MSCs) have not yet reached the industrial level, despite their many advantages, due to the need to optimize electrode material, device configuration, and solid electrolyte in order to improve their performance.
Article
Chemistry, Physical
Yuanyuan Miao, Saifei Yuan, Hao Ren, Ahmed Addad, Alexandre Barras, Pascal Roussel, Mohammed A. Amin, Sabine Szunerits, Rabah Boukherroub
Summary: In this study, an ultrathin hierarchical P-doped MoS2/Ni3S2 heterostructure was synthesized on nickel foam using a one-pot synthesis. The optimized catalyst showed promising activity for hydrogen and oxygen evolution reaction with low overpotentials. Furthermore, the electrode was applied for overall water splitting with low cell voltages and excellent stability. The results highlight the importance of doping and interface engineering in the design of advanced electrocatalytic materials.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Medicinal
Francesca Ruggieri, Philippe Hance, Bruna Gioia, Alexandre Biela, Pascal Roussel, Jean-Louis Hilbert, Nicolas Willand
Summary: This study describes a novel three-step large-scale extraction and purification method for the simultaneous purification of 11,13-dihydrolactucin (DHLc) and lactucin (Lc) from a chicory genotype rich in these sesquiterpene lactones (STLs) and their glucosyl and oxalyl conjugated forms. The results will facilitate the evaluation of the biological potential of chicory-derived STLs and their semisynthetic analogues.
Article
Chemistry, Multidisciplinary
Batoul Almoussawi, Hiroshi Kageyama, Pascal Roussel, Houria Kabbour
Summary: Oxychalcogenides are potential candidates for various applications including energy, and four new compounds in the Ba-V-Q-O system were synthesized and characterized. A novel structure type was found and the selective substitution of selenium was studied to tune the band gap and symmetry.
ACS ORGANIC & INORGANIC AU
(2023)
Article
Nanoscience & Nanotechnology
Go Inoue, Alexandre Barras, Yunfei Ma, Ning Cao, Alexandre Fadel, Pascal Roussel, Mu Naushad, Sabine Szunerits, Rabah Boukherroub
Summary: In this study, a solar-driven interfacial evaporator was developed using cigarette butts and petroleum coke powder. The 3D evaporator showed the best performance in terms of evaporation rate and solar conversion efficiency. It was also capable of producing safe fresh water from contaminated sources.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Khac Huy Dinh, Kevin Robert, Joelle Thuriot-Roukos, Marielle Huve, Pardis Simon, David Troadec, Christophe Lethien, Pascal Roussel
Summary: In this study, a vanadium tungsten nitride film was deposited by cosputtering as an efficient electrode for microsupercapacitors. The film exhibited excellent electrochemical performance with a capacitance of 700 Fcm(-3), and no loss in capacitance retention after 5000 cycles. Advanced characterization and mapping techniques were utilized to investigate the properties of the film.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Sandy Al Bacha, Sebastien Saitzek, Pascal Roussel, Marielle Huve, Emma E. McCabe, Houria Kabbour
Summary: This study presents the crystal structure, electronic properties, photocatalytic activity, and photocurrent response of a new antimony oxysulfide and its oxyselenide analogue. The results show promising potential for these materials in water splitting using solar energy, due to their low effective masses and strong bonding between lone pair electrons and anions.
CHEMISTRY OF MATERIALS
(2023)
Article
Plant Sciences
Marootpong Pooam, Enas M. M. El-Ballat, Nathalie Jourdan, Hayssam M. M. Ali, Christophe Hano, Margaret Ahmad, Mohamed A. A. El-Esawi
Summary: This study investigated the functional role of SNAC3 in enhancing arsenic stress tolerance and grain productivity in rice. The results showed that SNAC3 overexpression significantly improved rice tolerance to arsenic stress and boosted grain yield traits. SNAC3 overexpressing plants exhibited increased levels of antioxidants, photosynthesis, osmolyte accumulation, and stress-related gene expression.
Article
Chemistry, Multidisciplinary
Miguel Gallardo, Rodrigo Arancibia, Pascal Roussel, Natacha Henry
Summary: This paper describes a convenient synthesis method for obtaining new ferrocene-based sulfonyl diamine derivatives. The compounds [(?(5)-C5H4SO2NH-CH2-CH2-NH2)Fe(?(5)-C5H5)] (1) and [(?(5)-C5H4SO2NH-C6H4-NH2)Fe(?(5)-C5H5)] (2) were prepared by the reaction between (?(5)- C5H4SO2Cl)Fe(?(5)-C5H5) and the respective diamine precursor: ethylenediamine (1) or p-phenylenediamine (2) with good yields (86% for 1; 70% for 2). Both compounds were characterized by various spectroscopic techniques and cyclic voltammetry, and the molecular structure of 1 was determined by single-crystal X-ray diffraction.
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Blandine Fontaine, Youssef Benrkia, Jean-Francois Blach, Christian Mathieu, Pascal Roussel, Ahmad I. Ayesh, Adlane Sayede, Sebastien Saitzek
Summary: Two polymorphic phases (alpha- and beta-Cu2V2O7) of copper pyrovanadate were synthesized and the mechanisms of phase transitions were studied using TGA and DSC. High temperature X-ray diffraction revealed negative thermal expansion coefficients of the lattice parameters. The optimal conditions for producing dense thin films were determined using thermogravimetric analysis and differential scanning calorimetry. The thin films exhibited a beta-Cu2V2O7 polycrystalline phase and showed absorption in the visible range, making them suitable for use as photoanodes.
Article
Chemistry, Multidisciplinary
Preeti, Asif Raza, Amit Anand, Natacha Henry, Arun K. Sharma, Pascal Roussel, Vipan Kumar
Summary: The manuscript describes a highly stereo-/regioselective method for synthesizing a diverse array of substituted-3-hydroxy-2-oxindoles. The synthesized compounds showed anti-proliferative activity against various cell lines, and one compound demonstrated exceptional potency. It inhibited cell proliferation by inducing apoptosis, and molecular docking studies revealed its binding capability to the target protein.
