Inhibition of the PI3K–Akt and mTORC1 signaling pathways promotes the elongation of vascular endothelial cells

Dual treatments targeting IGF-1R, PI3K, mTORC or MEK synergize to inhibit cell growth, induce apoptosis, and arrest cell cycle at G1 phase in MDA-MB-231 cell line

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Regulation of Endothelial Cell Proliferation and Vascular Assembly through Distinct mTORC2 Signaling Pathways

(2015) Shan Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Making new contacts: the mTOR network in metabolism and signalling crosstalk

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The role of the RhoA/Rho kinase pathway in angiogenesis and its potential value in prostate cancer (Review)

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Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice

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A Comparison of Ku0063794, a Dual mTORC1 and mTORC2 Inhibitor, and Temsirolimus in Preclinical Renal Cell Carcinoma Models

(2013) Hao Zhang et al.   PLoS One

Vascular Normalization as a Therapeutic Strategy for Malignant and Nonmalignant Disease

(2013) S. Goel et al.   Cold Spring Harbor Perspectives in Medicine

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

Neovascularization in Tissue Engineering

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Alcohol-Induced Modulation of Rictor and mTORC2 Activity in C2C12 Myoblasts

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Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement

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PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

Rapamycin Regulates Endothelial Cell Migration through Regulation of the Cyclin-dependent Kinase Inhibitor p27Kip1

(2010) Stephanie C. Moss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

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Foxo1 is essential for in vitro vascular formation from embryonic stem cells

(2009) Seung-Hwan Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta

(2009) Boris Strilić et al.   DEVELOPMENTAL CELL

Different roles of Foxo1 and Foxo3 in the control of endothelial cell morphology

(2009) Mai Matsukawa et al.   GENES TO CELLS

Resistance to targeted therapy in renal-cell carcinoma

(2009) Brian I Rini et al.   LANCET ONCOLOGY

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

(2009) L.-A. Julien et al.   MOLECULAR AND CELLULAR BIOLOGY

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors

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Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: A combined gene therapy-cell transplantation approach

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