RhoA GTPase inhibition organizes contraction during epithelial morphogenesis

Force transmission in epithelial tissues

(2016) Claudia G. Vasquez et al.   DEVELOPMENTAL DYNAMICS

Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly

(2016) Mo Weng et al.   JOURNAL OF CELL BIOLOGY

Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis

(2016) Stephen Kerridge et al.   NATURE CELL BIOLOGY

Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover

(2015) Jeanne N. Jodoin et al.   DEVELOPMENTAL CELL

The Transgenic RNAi Project at Harvard Medical School: Resources and Validation

(2015) L. A. Perkins et al.   GENETICS

MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell–cell junctions in epithelial cells

(2015) Elaina B. Breznau et al.   MOLECULAR BIOLOGY OF THE CELL

A self-organized biomechanical network drives shape changes during tissue morphogenesis

(2015) Akankshi Munjal et al.   NATURE

YAP is essential for tissue tension to ensure vertebrate 3D body shape

(2015) Sean Porazinski et al.   NATURE

Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions

(2015) Rashmi Priya et al.   NATURE CELL BIOLOGY

Activator–inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium

(2015) William M. Bement et al.   NATURE CELL BIOLOGY

Intracellular signalling and intercellular coupling coordinate heterogeneous contractile events to facilitate tissue folding

(2015) Shicong Xie et al.   Nature Communications

Embryo-scale tissue mechanics during Drosophila gastrulation movements

(2015) Matteo Rauzi et al.   Nature Communications

The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis

(2015) Donglei Zhang et al.   eLife

Passive Mechanical Forces Control Cell-Shape Change during Drosophila Ventral Furrow Formation

(2014) Oleg Polyakov et al.   BIOPHYSICAL JOURNAL

Apical constriction: themes and variations on a cellular mechanism driving morphogenesis

(2014) A. C. Martin et al.   DEVELOPMENT

Dynamic Control of Excitatory Synapse Development by a Rac1 GEF/GAP Regulatory Complex

(2014) Kyongmi Um et al.   DEVELOPMENTAL CELL

Rho GTPase and Shroom direct planar polarized actomyosin contractility during convergent extension

(2014) Sérgio de Matos Simões et al.   JOURNAL OF CELL BIOLOGY

Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis

(2014) Claudia G. Vasquez et al.   JOURNAL OF CELL BIOLOGY

Arhgap28 Is a RhoGAP that Inactivates RhoA and Downregulates Stress Fibers

(2014) Ching-Yan Chloé Yeung et al.   PLoS One

Spatiotemporal control of epithelial remodeling by regulated myosin phosphorylation

(2014) K. E. Kasza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity

(2014) H. Sailem et al.   Open Biology

Rho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition

(2013) M. R. Clay et al.   DEVELOPMENT

A versatile platform for creating a comprehensive UAS-ORFeome library in Drosophila

(2013) J. Bischof et al.   DEVELOPMENT

A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA during Cytokinesis

(2013) Esther Zanin et al.   DEVELOPMENTAL CELL

The tension mounts: Stress fibers as force-generating mechanotransducers

(2013) Keith Burridge et al.   JOURNAL OF CELL BIOLOGY

Dynamic microtubules produce an asymmetric E-cadherin–Bazooka complex to maintain segment boundaries

(2013) Natalia A. Bulgakova et al.   JOURNAL OF CELL BIOLOGY

Apical domain polarization localizes actin–myosin activity to drive ratchet-like apical constriction

(2013) Frank M. Mason et al.   NATURE CELL BIOLOGY

Regulation of Epithelial Morphogenesis by the G Protein-Coupled Receptor Mist and Its Ligand Fog

(2013) A. J. Manning et al.   Science Signaling

FlyPrimerBank: An Online Database for Drosophila melanogaster Gene Expression Analysis and Knockdown Evaluation of RNAi Reagents

(2013) Yanhui Hu et al.   G3-Genes Genomes Genetics

Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure

(2012) Tamako Nishimura et al.   CELL

A Rho GTPase Signal Treadmill Backs a Contractile Array

(2012) Brian M. Burkel et al.   DEVELOPMENTAL CELL

Actin stress fibers - assembly, dynamics and biological roles

(2012) S. Tojkander et al.   JOURNAL OF CELL SCIENCE

Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

(2012) Aparna Ratheesh et al.   NATURE CELL BIOLOGY

Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis

(2012) M. A. Gelbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin cortex mechanics and cellular morphogenesis

(2012) Guillaume Salbreux et al.   TRENDS IN CELL BIOLOGY

An integrative approach to ortholog prediction for disease-focused and other functional studies

(2011) Yanhui Hu et al.   BMC BIOINFORMATICS

Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis

(2011) Romain Levayer et al.   NATURE CELL BIOLOGY

DRhoGEF2 Regulates Cellular Tension and Cell Pulsations in the Amnioserosa during Drosophila Dorsal Closure

(2011) Dulce Azevedo et al.   PLoS One

Cytoskeletal dynamics and supracellular organisation of cell shape fluctuations during dorsal closure

(2010) G. B. Blanchard et al.   DEVELOPMENT

Integration of contractile forces during tissue invagination

(2010) Adam C. Martin et al.   JOURNAL OF CELL BIOLOGY

Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis

(2010) Lina Greenberg et al.   MECHANISMS OF DEVELOPMENT

Planar polarized actomyosin contractile flows control epithelial junction remodelling

(2010) Matteo Rauzi et al.   NATURE

Tissue elongation requires oscillating contractions of a basal actomyosin network

(2010) Li He et al.   NATURE CELL BIOLOGY

PYK2/PDZ-RhoGEF Links Ca 2+ Signaling to RhoA

(2009) Zhekang Ying et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of RhoGEF proteins by G12/13-coupled receptors

(2009) Sandra Siehler   BRITISH JOURNAL OF PHARMACOLOGY

Apical constriction: A cell shape change that can drive morphogenesis

(2009) Jacob M. Sawyer et al.   DEVELOPMENTAL BIOLOGY

Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster

(2009) Koen J T Venken et al.   NATURE METHODS

Anillin Is a Scaffold Protein That Links RhoA, Actin, and Myosin during Cytokinesis

(2008) Alisa J. Piekny et al.   CURRENT BIOLOGY

Phosphoproteome Analysis ofDrosophila melanogasterEmbryos

(2008) Bo Zhai et al.   JOURNAL OF PROTEOME RESEARCH

Pulsed contractions of an actin–myosin network drive apical constriction

(2008) Adam C. Martin et al.   NATURE

Regulation of cytokinesis by Rho GTPase flux

(2008) Ann L. Miller et al.   NATURE CELL BIOLOGY

RhoA and microtubule dynamics control cell–basement membrane interaction in EMT during gastrulation

(2008) Yukiko Nakaya et al.   NATURE CELL BIOLOGY