Journal
PHARMACEUTICALS
Volume 15, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ph15030264
Keywords
boron; medicinal chemistry; diazaborines; boronic acids; boron clusters; carboranes; benzoxaboroles; bortezomib
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Funding
- Research Manitoba New Investigator Operating Grant
- University of Manitoba Student Union Undergraduate Research Award
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This review discusses the history of boron's early use in drugs and the use of boron functional groups in medicinal chemistry. It highlights critical developments from these functional groups and showcases the application of boron in prodrugs, softdrugs, and nanocarriers.
In this review, the history of boron's early use in drugs, and the history of the use of boron functional groups in medicinal chemistry applications are discussed. This includes diazaborines, boronic acids, benzoxaboroles, boron clusters, and carboranes. Furthermore, critical developments from these functional groups are highlighted along with recent developments, which exemplify potential prospects. Lastly, the application of boron in the form of a prodrug, softdrug, and as a nanocarrier are discussed to showcase boron's emergence into new and exciting fields. Overall, we emphasize the evolution of organoboron therapeutic agents as privileged structures in medicinal chemistry and outline the impact that boron has had on drug discovery and development.
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