The Boron Advantage: The Evolution and Diversification of Boron's Applications in Medicinal Chemistry

In this review, the history of boron's early use in drugs, and the history of the use of boron functional groups in medicinal chemistry applications are discussed. This includes diazaborines, boronic acids, benzoxaboroles, boron clusters, and carboranes. Furthermore, critical developments from these functional groups are highlighted along with recent developments, which exemplify potential prospects. Lastly, the application of boron in the form of a prodrug, softdrug, and as a nanocarrier are discussed to showcase boron's emergence into new and exciting fields. Overall, we emphasize the evolution of organoboron therapeutic agents as privileged structures in medicinal chemistry and outline the impact that boron has had on drug discovery and development.

Automated summary

This review discusses the history of boron's early use in drugs and the use of boron functional groups in medicinal chemistry. It highlights critical developments from these functional groups and showcases the application of boron in prodrugs, softdrugs, and nanocarriers.