Review
Biochemistry & Molecular Biology
Saverio Sabina, Alessandra Panico, Pierpaolo Mincarone, Carlo Giacomo Leo, Sergio Garbarino, Tiziana Grassi, Francesco Bagordo, Antonella De Donno, Egeria Scoditti, Maria Rosaria Tumolo
Summary: This review synthesizes human studies on the expression of miRNA in the pathogenesis of chronic primary pain and chronic secondary pain. An in silico analysis was performed to understand the potential impact of miRNAs in these conditions. The findings, methodological issues, and challenges of miRNA research in chronic pain are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Xinhe Zhang, Xing Jin, Lin Guan, Xuyong Lin, Xuedan Li, Yiling Li
Summary: IgG4-related disease is an immune-mediated chronic, systemic, and autoinflammatory disease that can affect various organs throughout the body. The most commonly affected areas are the pancreas and biliary system. This article reports two special cases involving atrophic gastritis and intestinal polyps, providing empirical and theoretical basis for clinical diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Robert S. Talay, Yaling Liu, Matthew Michael, Anna Li, Isabel D. Friesner, Fei Zeng, Guanghao Sun, Zhe Sage Chen, Qiaosheng Zhang, Jing Wang
Summary: The study found that AMPAkines can restore endogenous anti-nociceptive functions in the PL-PFC region, providing a successful strategy for treating chronic neuropathic pain.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Clinical Neurology
Marinos C. Dalakas
Summary: This paper discusses IgG4 antibody-mediated neurological disorders, focusing on their clinical spectrum and immunopathogenesis. The unique functional effects of IgG4 subclass compared to other antibody subclasses are highlighted. IgG4 antibodies exert pathogenic effects on their targeted antigens through blocking enzymatic activity or disrupting protein-protein interactions, rather than activating complement or binding to inhibitory receptors. Conventional anti-inflammatory therapies are ineffective in treating IgG4-ND, therefore targeting the activated plasmablasts involved in IgG4 antibody production may be a meaningful therapeutic target.
Review
Immunology
George Sideris-Lampretsas, Marzia Malcangio
Summary: This review summarizes the existing preclinical evidence on how the CNS compartment and sex impact microglia functions in health, emphasizing recent advances in transcriptomics analyses for characterizing disease-associated microglial states. The specific scenario of peripheral nerve or tissue injury inducing expression of a specific subset of genes in microglia in the dorsal horn of the spinal cord is discussed, along with the possibility of a unique microglia transcriptional profile associated with chronic pain conditions. The evidence also suggests microglial activation in pain-related areas of the brain can be observed in models of neuropathic pain, highlighting the potential for future studies to further explore neuroimmune interactions in chronic pain using novel approaches like scRNA-seq and CYTOF.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Gastroenterology & Hepatology
Satoshi Kosaka, Fumio Tanaka, Akinobu Nakata, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Toshio Watanabe, Yasuhiro Fujiwara
Summary: In patients with eosinophilic gastroenteritis, there is a significant accumulation of IgG4 in the gastrointestinal mucosa. The correlation between serum egg white-specific IgG4 levels and the proportion of IgG4-stained areas in the small intestine suggests a role for IgG4 in the pathophysiology of the disease.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Anesthesiology
Qing-Ren Liu, Jue Xie, Yu-Chen Dai, Mu-Huo Ji, Cheng-Mao Zhou, Han-Wen Gu, Hui-Jie Shang, Xing-Bing Sun, Jian-Jun Yang
Summary: The study showed that ultrasound-guided QLB provides superior short-term analgesia and reduces oxycodone consumption and the incidence of PONV after gastrointestinal surgery. However, the incidence of chronic pain was not significantly affected by this anesthetic technique.
Review
Neurosciences
Fan-He Song, Dai-Qiang Liu, Ya-Qun Zhou, Wei Mei
Summary: This article summarizes the role and mechanisms of SIRT1 in chronic pain, exploring its regulation of inflammation, oxidative stress, and mitochondrial function, suggesting that SIRT1 agonists may serve as potential therapeutic drugs for chronic pain.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Masaru Tanaka, Nora Torok, Fanni Toth, Agnes Szabo, Laszlo Vecsei
Summary: Chronic pain is a persistent or recurrent, unpleasant sensory and emotional experience lasting more than three months. Recent classifications by the International Association for the Study of Pain will come into effect in 2022, emphasizing neurological pathology in chronic pain while downplaying psychological or social factors. This review delves into the pain pathway, mechanisms of pain, sensitization, chronic inflammation, and the role of metabolites, exploring how psychosocial and behavioral factors contribute to the development of chronic pain.
Article
Medicine, General & Internal
Marika C. Moller, Nils Berginstrom, Bijar Ghafouri, Anna Holmqvist, Monika Lofgren, Love Nordin, Britt-Marie Stalnacke
Summary: This study aims to investigate the presence of mental fatigue, cognitive fatigability, executive functions, and their relation to other cognitive functions, inflammatory biomarkers, and brain connectivity in patients with chronic pain. The study will also control for pain-related factors and compare with healthy controls. The results will contribute to new models of fatigue and cognition in chronic pain.
Review
Chemistry, Medicinal
Marion Voute, Veronique Morel, Gisele Pickering
Summary: Topical lidocaine is a safe and effective option for pain management, with proven efficacy in various pain conditions. It can be used alone or in conjunction with systemic drugs and non-pharmacological approaches for optimized pain management and multimodal analgesia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Qing-Ren Liu, Yu-Chen Dai, Mu-Huo Ji, Li-Li Qiu, Pan-Miao Liu, Xing-Bing Sun, Jian-Jun Yang
Summary: This study aimed to identify the predictors of acute postsurgical pain (APSP) trajectories and explore the association between APSP trajectories and chronic postsurgical pain (CPSP). The results showed that preoperative anxiety and postoperative analgesic consumption could predict APSP trajectories, while APSP trajectories and age were predictors of CPSP.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Man-Kyo Chung, Sheng Wang, Se-Lim Oh, Yu Shin Kim
Summary: The oral cavity is a portal into the digestive system with unique sensory properties. The oral mucosa needs to be sensitive and selective to differentiate harmful toxins from edible food, but also insensitive to endure noxious irritation. Chronic pain in the oral mucosa is often due to ulcers, and conditions like atypical odontalgia and burning mouth syndrome pose challenges in diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Mia Y. Masuda, William E. LeSuer, Jennifer L. Horsley-Silva, Arina Putikova, Matthew R. Buras, Jessica B. Gibson, Grace C. Pyon, Temeka D. Simmons, Alfred D. Doyle, Benjamin L. Wright
Summary: Food-specific immunoglobulin G4 (FS-IgG4) is associated with eosinophilic esophagitis (EoE) and elevated levels of FS-IgG4 are found in plasma and throughout the upper gastrointestinal tract in EoE subjects. These levels correlate with endoscopic findings and esophageal eosinophilia.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Clayton Culp, Hee Kee Kim, Salahadin Abdi
Summary: Ketamine has shown promising effectiveness in treating chronic pain, especially cancer-related neuropathic pain. It has the potential to reduce opioid use and exhibits improved safety profiles at sub-anesthetic concentrations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Elvira Rostanzo, Marco Marchetti, Ilenia Casini, Anna Maria Aloisi
Summary: The study found that women following a low-calorie high-protein diet could effectively reduce weight and improve symptoms of food addiction and binge eating. Muscle mass was preserved, and the research suggests that ketogenic diets may have potential therapeutic benefits for treating addiction to high-calorie foods.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)