Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

(2020) Shannon Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Highly Flexible Ligand Docking: Benchmarking of the DockThor Program on the LEADS-PEP Protein–Peptide Data Set

(2020) Karina B. Santos et al.   Journal of Chemical Information and Modeling

Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

(2020) Bruno M. Simões et al.   ONCOGENE

Breast Cancer Prevention-Is there a Future for Sulforaphane and Its Analogs?

(2020) Dominika Kuran et al.   Nutrients

In the triple-negative breast cancer MDA-MB-231 cell line, sulforaphane enhances the intracellular accumulation and anticancer action of doxorubicin encapsulated in liposomes

(2019) Lidia Mielczarek et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors

(2019) Aixin Geng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis and Biological Evaluation of Novel Benzoylimidazole Derivatives as Raf and Histone Deacetylases Dual Inhibitors

(2019) Xin Chen et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line

(2018) Małgorzata Milczarek et al.   FOOD AND CHEMICAL TOXICOLOGY

Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice

(2018) Jei-Ming Peng et al.   HEPATOLOGY

Correlation Between Raf/MEK/ERK Signaling Pathway and Clinicopathological Features and Prognosis for Patients With Breast Cancer Having Axillary Lymph Node Metastasis

(2018) Guo-Li Shao et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Targeting oncogenic Raf protein-serine/threonine kinases in human cancers

(2018) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells

(2017) Kendra Royston et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma

(2017) Sufang Yang et al.   Oncology Letters

Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

(2017) Sandra Tavares et al.   Nature Communications

Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells

(2017) Anna Lewinska et al.   Theranostics

Sulforaphane Induced Apoptosis via Promotion of Mitochondrial Fusion and ERK1/2-Mediated 26S Proteasome Degradation of Novel Pro-survival Bim and Upregulation of Bax in Human Non-Small Cell Lung Cancer Cells

(2017) Yang Geng et al.   Journal of Cancer

Breast cancer incidence and mortality: trends over 40 years among women in Shanghai, China

(2016) Z. Huang et al.   ANNALS OF ONCOLOGY

Gene network analysis reveals the association of important functional partners involved in antibiotic resistance: A report on an important pathogenic bacterium Staphylococcus aureus

(2016) P. Anitha et al.   GENE

MiR-487a Promotes TGF-β1-induced EMT, the Migration and Invasion of Breast Cancer Cells by Directly Targeting MAGI2

(2016) Mengtao Ma et al.   International Journal of Biological Sciences

The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC

(2016) Lei Li et al.   Oncology Letters

Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy

(2015) L. L. Atwell et al.   Cancer Prevention Research

IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics

(2015) Takashi Watanabe et al.   CELL STRUCTURE AND FUNCTION

TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis

(2015) M-F Pang et al.   ONCOGENE

Sulforaphane Inhibits Growth of Human Breast Cancer Cells and Augments the Therapeutic Index of the Chemotherapeutic Drug, Gemcitabine

(2014) Arif Hussain et al.   Asian Pacific Journal of Cancer Prevention

Sulforaphane and prostate cancer interception

(2014) Maria H. Traka et al.   DRUG DISCOVERY TODAY

New enantiomeric fluorine-containing derivatives of sulforaphane: Synthesis, absolute configurations and biological activity

(2014) Piotr Kiełbasiński et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration

(2014) J. Mooz et al.   Science Signaling

Extracellular Signal-regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration

(2013) Kendra A. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin stress fibre subtypes in mesenchymal-migrating cells

(2013) T. Vallenius   Open Biology

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches

(2012) Antonella De Luca et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sulforaphane Induces Cell Cycle Arrest and Apoptosis in Acute Lymphoblastic Leukemia Cells

(2012) Koramit Suppipat et al.   PLoS One

Focal Adhesion Kinase Stabilizes the Cytoskeleton

(2011) Ben Fabry et al.   BIOPHYSICAL JOURNAL

Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts

(2011) Dan Xu et al.   CELLULAR SIGNALLING

IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton

(2011) Hugh Kim et al.   FEBS LETTERS

Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly

(2011) Praveen Rajendran et al.   Molecular Cancer

RAF protein-serine/threonine kinases: Structure and regulation

(2010) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer

(2010) Ahmad Faizal Abdull Razis et al.   INTERNATIONAL JOURNAL OF CANCER

Thrombin promotes actin stress fiber formation in RPE through Rho/ROCK-mediated MLC phosphorylation

(2010) Ariadna Yolanda Ruiz-Loredo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Breast Cancer Before Age 40 Years

(2009) Carey K. Anders et al.   SEMINARS IN ONCOLOGY

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Sulforaphane Enhances the Therapeutic Potential of TRAIL in Prostate Cancer Orthotopic Model through Regulation of Apoptosis, Metastasis, and Angiogenesis

(2008) S. Shankar et al.   CLINICAL CANCER RESEARCH

Regulation of RAF Activity by 14-3-3 Proteins

(2008) Andreas Fischer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

STRING 8--a global view on proteins and their functional interactions in 630 organisms

(2008) L. J. Jensen et al.   NUCLEIC ACIDS RESEARCH